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Ocular Lesions Following Methyl Isocyanate Contamination: The Bhopal Experience

Ocular Lesions Following Methyl Isocyanate Contamination: The Bhopal Experience Abstract To the Editor. —During the recent methyl isocyanate leak in Bhopal, India, 232 children were admitted to the Pediatric and Eye Ward of Hamidia Hospital. We report the findings in those children.Exposure lasted one to two hours in 78.4% and greater than two hours in 21.6% of children. All patients complained of severe ocular burning, and other symptoms included lid swelling (94.8%), ocular redness (93.1%), watering (88.7%), pain (75.8%), and photophobia (43.9%). On examination, 215 patients (92.6%) had only mild involvement, with conjunctival vascular engorgement and chemosis. Fourteen patients (6.03% ) had corneal involvement, which ranged from punctate keratopathy to partial or total epithelial denudation. Only three patients (1.28%) had more severe involvement, with stromal haze and iritis. Epithelial healing in all cases was complete within five days, and stromal opacification resolved in an additional two to three days. No secondary infections occurred, and no permanent ocular sequelae ensued. Treatment References 1. Rye WA: Human response to isocyanate exposure . J Occup Med 1973;15:306-307. 2. Kimmerle G, Eben A: Zur Toxicitat von Methylisocynat und dessen quantitativer Best immung in der Luft . Arch Toxicol 1964;20:235-241. 3. Ryan RW: Chemical eye hazard in industry , in Allen JH (ed): Industrial and Traumatic Ophthalmology . St Louis, CV Mosby Co, 1964, p 123. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Ocular Lesions Following Methyl Isocyanate Contamination: The Bhopal Experience

Ocular Lesions Following Methyl Isocyanate Contamination: The Bhopal Experience

Abstract

Abstract To the Editor. —During the recent methyl isocyanate leak in Bhopal, India, 232 children were admitted to the Pediatric and Eye Ward of Hamidia Hospital. We report the findings in those children.Exposure lasted one to two hours in 78.4% and greater than two hours in 21.6% of children. All patients complained of severe ocular burning, and other symptoms included lid swelling (94.8%), ocular redness (93.1%), watering (88.7%), pain (75.8%), and photophobia (43.9%). On examination,...
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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1985.01050110021002
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —During the recent methyl isocyanate leak in Bhopal, India, 232 children were admitted to the Pediatric and Eye Ward of Hamidia Hospital. We report the findings in those children.Exposure lasted one to two hours in 78.4% and greater than two hours in 21.6% of children. All patients complained of severe ocular burning, and other symptoms included lid swelling (94.8%), ocular redness (93.1%), watering (88.7%), pain (75.8%), and photophobia (43.9%). On examination, 215 patients (92.6%) had only mild involvement, with conjunctival vascular engorgement and chemosis. Fourteen patients (6.03% ) had corneal involvement, which ranged from punctate keratopathy to partial or total epithelial denudation. Only three patients (1.28%) had more severe involvement, with stromal haze and iritis. Epithelial healing in all cases was complete within five days, and stromal opacification resolved in an additional two to three days. No secondary infections occurred, and no permanent ocular sequelae ensued. Treatment References 1. Rye WA: Human response to isocyanate exposure . J Occup Med 1973;15:306-307. 2. Kimmerle G, Eben A: Zur Toxicitat von Methylisocynat und dessen quantitativer Best immung in der Luft . Arch Toxicol 1964;20:235-241. 3. Ryan RW: Chemical eye hazard in industry , in Allen JH (ed): Industrial and Traumatic Ophthalmology . St Louis, CV Mosby Co, 1964, p 123.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1985

References

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