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OCULAR INVOLVEMENT IN LYMPHOMATOUS DISEASE

OCULAR INVOLVEMENT IN LYMPHOMATOUS DISEASE Abstract OCULAR invlovement in lymphomatous disease has been a sufficiently uncommon event to warrant isolated and collected case reports at various intervals in the ophthalmologic literature. Until recent years, the ocular manifestations were usually reported as ophthalmologic entities, and little attention was given to the occurrence of systemic disease, either prior to or following ocular involvement. The opinion commonly expressed in the older ophthalmologic literature is that isolated ocular lymphoma generally is not followed by systemic involvement. This stands in conflict with the more recent concepts that appearance of a lymphoma anywhere in the body heralds eventual lymphomatous dissemination, though it be many years distant. The problem of whether a simple ocular lymphoma should be considered as the first manifestation of a systemic disease has not been settled. Since the ophthalmologist rarely has the privilege of seeing the patient who suffers systemic involvement without recurrent ophthalmic disease, the question is one References 1. Custer, R. P.: An Atlas of the Blood and Bone Marrow , Philadelphia, W. B. Saunders & Company, 1949, pp. 94-99. 2. Gall, E. A., and Mallory, T. B.: Malignant Lymphoma: A Clinicopathologic Survey of 618 Cases , Am. J. Path. 18:381, 1942. 3. Heath,P.: Ocular Lymphomas , Tr. Am. Ophth. Soc. 46:385, 1948. 4. Törnquist, R.: Ophthalmic Symptoms in Giant Follicular Lymphadenopathy , Arch. Ophth. 44:842, 1950.Crossref 5. Rados, A.: Reticulum Cell Sarcoma of the Conjunctiva , Arch. Ophth. 35:400, 1946.Crossref 6. (b) Braley, A. E., and Alexander, R. C.: Virus Studies in Lymphomatoid Diseases of the Ocular Adnexa , Am. J. Ophth. 30:1369, 1947. 7. (c) Butler, T. H.: A Case of Sarcoma of the Lacrimal Sac , Arch. Ophth. 43:16, 1914. 8. (d) Coats, G.: Lymphoma and Lymphosarcoma of the Conjunctiva , Arch. Ophth. 44:235, 1915. 9. (e) Cookson, H. A., and MacRae, A.: Lymphoid Tumor of the Lacrimal Gland , Brit. J. Ophth. 22:385, 1938.Crossref 10. (h) Kaufman, S. I.: Mikulicz Syndrome: An Early Manifestation of Hodgkin's Disease; Report of a Case , Eye, Ear, Nose & Throat Month. 29:257, 1950. 11. (i) Metivier, V. M.: Lymphosarcoma of the Eyelid , Brit. J. Ophth. 21:202, 1937. 12. (j) Reeves, R. J.: Lymphoblastoma (Hodgkin's Disease) of the Orbit , Am. J. Roentgenol. 17:642, 1927. 13. (k) Rosenthal, N.; Harris, W., and Kean, A.: Clinical and Radiotherapeutic Considerations of Follicular Lymphoblastoma , Am. J. Roentgenol. 29:95, 1933. 14. (l) Sédan, J.; Astier, A., and Caudière, M.: Lymphoblastome du sac lachrymal géneralisé après étape orbitaire, à la totalité de l'appareil lymphatique , Bull. et mém. Soc. franç. opht. 44:249, 1939 15. (m) Stansbury, F. C.: Lymphosarcoma of the Eyelid , Arch. Ophth. 40:518, 1948. 16. (n) van Walbeek, K.: A Case of Reticulum Cell Sarcoma of the Plica Semilunaris , Acta ophth. 24:183, 1946. 17. (o) Weve, H.: Ein lymphatische tumor van der traansak , Nederl. tijdschr. geneesk. 1:696, 1928. 18. (a) Bateman, O. J.; Squires, G., and Thannhauser, S. J.: Hodgkin's Disease Associated with Schilder's Disease , Ann. Int. Med. 22:426, 1945. 19. (b) Cooper, E. L., and Riker, J. L.: Malignant Lymphoma of the Uveal Tract , Tr. Am. Acad. Ophth. 54:116, 1950. 20. (c) Francia, C.: Cheratite in morbo di Hodgkin , Rass. ital. ottal. 19:140, 1950 21. abstracted, Excerpta Med. XII 9:692, 1950. 22. (d) Gross, P., and Votawa, G. J.: Bilateral Symmetrical Exophthalmos Due to Retrobulbar Lymphosarcoma: Report of a Case , Radiology 31:620, 1938.Crossref 23. (e) Jensen, J. P.: Conjunctival Lymphoma, Acta ophth. 18:67, 1940.Crossref 24. (f) Kamellin, S.: Uveitis Associated with Hodgkin's Disease: Report of a Case , Arch. Ophth. 31:517, 1944.Crossref 25. (g) Kravitz, D.: Hodgkin's Disease of the Lid , Arch. Ophth. 21:844, 1939.Crossref 26. (h) Matteucci, P.: Corneal Lesions in Hodgkin's Disease , Am. J. Ophth. 30:136, 1947. 27. (i) MacKechnie, H. N.: One Case of Hodgkin's Disease Treated Over a Period of 6 Years with Recent Ocular Disturbances , S. Clin. North America 7:761, 1929. 28. (j) Meigs, A. V., and de Schweinitz, G. E.: Round-Celled Sarcoma of the Anterior Mediastinum: Extensive Metastasis, Including the Brain, Both Choroid Coats, Oculo-Motor and Optic Nerves, and External Ocular Muscles , Am. J. M. Sc. 108:193, 1894.Crossref 29. (k) Ridley, N. C.: An Unusual Complication of Hodgkin's Disease , Tr. Ophth. Soc. U. Kingdom 49:399, 1929. 30. (l) Sachs, B.: Eye Conditions in Leukemia , Arch. Ophth. 57:474, 1928. 31. von Bahr, G.: A Case of Uveo-Parotitis with Perivasculitis and Other Rare Symptoms , Acta. ophth. 16:101, 1938.Crossref 32. (a) Avery, J. W., and Warren, J. W.: An Unusual Case of Hodgkin's Disease , Arch. Ophth. 26:1019, 1941Crossref 33. 34:318, 1945. 34. (b) Chambers, B. M.: Therapy of Giant Follicular Lymphoma with Nitrogen Mustard: Report of a Case , 43:520, 1950. 35. (e) Saradarian, A. V.: Bilateral Subconjunctival Lymphoid Infiltration: Report of a Case , Arch. Ophth. 24:980, 1940.Crossref 36. (f) Tooke, F. T.: A Case of Aleukemic Lymphosis Involving the Upper Lids, with Pathologic Findings , Brit. J. Ophth. 23:444, 1939.Crossref 37. (a) Reese, A. B.: Tumors of the Eye , New York, Paul B. Hoeber, Inc., 1951. 38. (c) McGavic, J. S.: Lymphomatoid Disease Involving the Eye and Its Adnexa , Arch. Ophth. 30:179, 1943.Crossref 39. Craver, L. F.: Lymphomas and Leukemias , Bull. New York Acad. Med. 23:79, 1947. 40. (c) Sugarbaker, E. D., and Craver, L. F.: Lymphosarcoma: A Study of 196 Cases with Biopsy , J. A. M. A. 115:17 and 112, 1940. 41. (a) Benedict, W. L., and Martens, T. G.: Malignant Lymphocytic Tumors of the Orbit , S. Clin. North America 26:871, 1946. 42. (b) Forrest, A. W.: Intraorbital Tumors , Arch. Ophth. 41:198, 1949.Crossref 43. (d) Iles, A. E., and Short, A. R.: Orbital Tumours , Brit. J. Surg. 31:147, 1943.Crossref 44. (e) Ingalls, R. G.: Orbital Tumors , Am. J. Ophth. 32:1595, 1949. 45. Rones, B., cited by Heath.3 46. Footnote deleted. 47. Catlin, D.: Lymphosarcoma of the Head and Neck , Am. J. Roentgenol. 59:354, 1948. 48. Stout, A. P.: Results of Treatment of Lymphosarcoma , New York J. Med. 47:158, 1947. 49. Block, M., and Jacobson, L. O.: Management of the Lymphomas , M. Clin. North America 35:102, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

OCULAR INVOLVEMENT IN LYMPHOMATOUS DISEASE

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
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0096-6339
DOI
10.1001/archopht.1952.00920010336008
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Abstract

Abstract OCULAR invlovement in lymphomatous disease has been a sufficiently uncommon event to warrant isolated and collected case reports at various intervals in the ophthalmologic literature. Until recent years, the ocular manifestations were usually reported as ophthalmologic entities, and little attention was given to the occurrence of systemic disease, either prior to or following ocular involvement. The opinion commonly expressed in the older ophthalmologic literature is that isolated ocular lymphoma generally is not followed by systemic involvement. This stands in conflict with the more recent concepts that appearance of a lymphoma anywhere in the body heralds eventual lymphomatous dissemination, though it be many years distant. The problem of whether a simple ocular lymphoma should be considered as the first manifestation of a systemic disease has not been settled. Since the ophthalmologist rarely has the privilege of seeing the patient who suffers systemic involvement without recurrent ophthalmic disease, the question is one References 1. Custer, R. P.: An Atlas of the Blood and Bone Marrow , Philadelphia, W. B. Saunders & Company, 1949, pp. 94-99. 2. Gall, E. A., and Mallory, T. B.: Malignant Lymphoma: A Clinicopathologic Survey of 618 Cases , Am. J. Path. 18:381, 1942. 3. Heath,P.: Ocular Lymphomas , Tr. Am. Ophth. Soc. 46:385, 1948. 4. Törnquist, R.: Ophthalmic Symptoms in Giant Follicular Lymphadenopathy , Arch. Ophth. 44:842, 1950.Crossref 5. Rados, A.: Reticulum Cell Sarcoma of the Conjunctiva , Arch. Ophth. 35:400, 1946.Crossref 6. (b) Braley, A. E., and Alexander, R. C.: Virus Studies in Lymphomatoid Diseases of the Ocular Adnexa , Am. J. Ophth. 30:1369, 1947. 7. (c) Butler, T. H.: A Case of Sarcoma of the Lacrimal Sac , Arch. Ophth. 43:16, 1914. 8. (d) Coats, G.: Lymphoma and Lymphosarcoma of the Conjunctiva , Arch. Ophth. 44:235, 1915. 9. (e) Cookson, H. A., and MacRae, A.: Lymphoid Tumor of the Lacrimal Gland , Brit. J. Ophth. 22:385, 1938.Crossref 10. (h) Kaufman, S. I.: Mikulicz Syndrome: An Early Manifestation of Hodgkin's Disease; Report of a Case , Eye, Ear, Nose & Throat Month. 29:257, 1950. 11. (i) Metivier, V. M.: Lymphosarcoma of the Eyelid , Brit. J. Ophth. 21:202, 1937. 12. (j) Reeves, R. J.: Lymphoblastoma (Hodgkin's Disease) of the Orbit , Am. J. Roentgenol. 17:642, 1927. 13. (k) Rosenthal, N.; Harris, W., and Kean, A.: Clinical and Radiotherapeutic Considerations of Follicular Lymphoblastoma , Am. J. Roentgenol. 29:95, 1933. 14. (l) Sédan, J.; Astier, A., and Caudière, M.: Lymphoblastome du sac lachrymal géneralisé après étape orbitaire, à la totalité de l'appareil lymphatique , Bull. et mém. Soc. franç. opht. 44:249, 1939 15. (m) Stansbury, F. C.: Lymphosarcoma of the Eyelid , Arch. Ophth. 40:518, 1948. 16. (n) van Walbeek, K.: A Case of Reticulum Cell Sarcoma of the Plica Semilunaris , Acta ophth. 24:183, 1946. 17. (o) Weve, H.: Ein lymphatische tumor van der traansak , Nederl. tijdschr. geneesk. 1:696, 1928. 18. (a) Bateman, O. J.; Squires, G., and Thannhauser, S. J.: Hodgkin's Disease Associated with Schilder's Disease , Ann. Int. Med. 22:426, 1945. 19. (b) Cooper, E. L., and Riker, J. L.: Malignant Lymphoma of the Uveal Tract , Tr. Am. Acad. Ophth. 54:116, 1950. 20. (c) Francia, C.: Cheratite in morbo di Hodgkin , Rass. ital. ottal. 19:140, 1950 21. abstracted, Excerpta Med. XII 9:692, 1950. 22. (d) Gross, P., and Votawa, G. J.: Bilateral Symmetrical Exophthalmos Due to Retrobulbar Lymphosarcoma: Report of a Case , Radiology 31:620, 1938.Crossref 23. (e) Jensen, J. P.: Conjunctival Lymphoma, Acta ophth. 18:67, 1940.Crossref 24. (f) Kamellin, S.: Uveitis Associated with Hodgkin's Disease: Report of a Case , Arch. Ophth. 31:517, 1944.Crossref 25. (g) Kravitz, D.: Hodgkin's Disease of the Lid , Arch. Ophth. 21:844, 1939.Crossref 26. (h) Matteucci, P.: Corneal Lesions in Hodgkin's Disease , Am. J. Ophth. 30:136, 1947. 27. (i) MacKechnie, H. N.: One Case of Hodgkin's Disease Treated Over a Period of 6 Years with Recent Ocular Disturbances , S. Clin. North America 7:761, 1929. 28. (j) Meigs, A. V., and de Schweinitz, G. E.: Round-Celled Sarcoma of the Anterior Mediastinum: Extensive Metastasis, Including the Brain, Both Choroid Coats, Oculo-Motor and Optic Nerves, and External Ocular Muscles , Am. J. M. Sc. 108:193, 1894.Crossref 29. (k) Ridley, N. C.: An Unusual Complication of Hodgkin's Disease , Tr. Ophth. Soc. U. Kingdom 49:399, 1929. 30. (l) Sachs, B.: Eye Conditions in Leukemia , Arch. Ophth. 57:474, 1928. 31. von Bahr, G.: A Case of Uveo-Parotitis with Perivasculitis and Other Rare Symptoms , Acta. ophth. 16:101, 1938.Crossref 32. (a) Avery, J. W., and Warren, J. W.: An Unusual Case of Hodgkin's Disease , Arch. Ophth. 26:1019, 1941Crossref 33. 34:318, 1945. 34. (b) Chambers, B. M.: Therapy of Giant Follicular Lymphoma with Nitrogen Mustard: Report of a Case , 43:520, 1950. 35. (e) Saradarian, A. V.: Bilateral Subconjunctival Lymphoid Infiltration: Report of a Case , Arch. Ophth. 24:980, 1940.Crossref 36. (f) Tooke, F. T.: A Case of Aleukemic Lymphosis Involving the Upper Lids, with Pathologic Findings , Brit. J. Ophth. 23:444, 1939.Crossref 37. (a) Reese, A. B.: Tumors of the Eye , New York, Paul B. Hoeber, Inc., 1951. 38. (c) McGavic, J. S.: Lymphomatoid Disease Involving the Eye and Its Adnexa , Arch. Ophth. 30:179, 1943.Crossref 39. Craver, L. F.: Lymphomas and Leukemias , Bull. New York Acad. Med. 23:79, 1947. 40. (c) Sugarbaker, E. D., and Craver, L. F.: Lymphosarcoma: A Study of 196 Cases with Biopsy , J. A. M. A. 115:17 and 112, 1940. 41. (a) Benedict, W. L., and Martens, T. G.: Malignant Lymphocytic Tumors of the Orbit , S. Clin. North America 26:871, 1946. 42. (b) Forrest, A. W.: Intraorbital Tumors , Arch. Ophth. 41:198, 1949.Crossref 43. (d) Iles, A. E., and Short, A. R.: Orbital Tumours , Brit. J. Surg. 31:147, 1943.Crossref 44. (e) Ingalls, R. G.: Orbital Tumors , Am. J. Ophth. 32:1595, 1949. 45. Rones, B., cited by Heath.3 46. Footnote deleted. 47. Catlin, D.: Lymphosarcoma of the Head and Neck , Am. J. Roentgenol. 59:354, 1948. 48. Stout, A. P.: Results of Treatment of Lymphosarcoma , New York J. Med. 47:158, 1947. 49. Block, M., and Jacobson, L. O.: Management of the Lymphomas , M. Clin. North America 35:102, 1951.

Journal

A.M.A. Archives of Ophthalmology – American Medical Association

Published: Sep 1, 1952

References

  • An Atlas of the Blood and Bone Marrow
    Custer , R. P.
  • Malignant Lymphoma: A Clinicopathologic Survey of 618 Cases
    Gall , E. A., and Mallory, T. B.
  • Ocular Lymphomas
    Heath ,P.
  • Ophthalmic Symptoms in Giant Follicular Lymphadenopathy
    Törnquist , R.
  • Reticulum Cell Sarcoma of the Conjunctiva
    Rados , A.
  • Virus Studies in Lymphomatoid Diseases of the Ocular Adnexa
    Braley , A. E., and Alexander, R. C.
  • A Case of Sarcoma of the Lacrimal Sac
    Butler , T. H.
  • Lymphoma and Lymphosarcoma of the Conjunctiva
    Coats , G.
  • Lymphoid Tumor of the Lacrimal Gland
    Cookson , H. A., and MacRae, A.
  • Mikulicz Syndrome: An Early Manifestation of Hodgkin's Disease
    Kaufman , S. I.
  • Lymphosarcoma of the Eyelid
    Metivier , V. M.
  • Lymphoblastoma (Hodgkin's Disease) of the Orbit
    Reeves , R. J.
  • Clinical and Radiotherapeutic Considerations of Follicular Lymphoblastoma
    Rosenthal , N.; Harris, W., and Kean, A.
  • Lymphoblastome du sac lachrymal géneralisé après étape orbitaire, à la totalité de l'appareil lymphatique
    Sédan , J.; Astier, A., and Caudière, M.
  • Lymphosarcoma of the Eyelid
    Stansbury , F. C.
  • A Case of Reticulum Cell Sarcoma of the Plica Semilunaris
    van Walbeek , K.
  • Ein lymphatische tumor van der traansak
    Weve , H.
  • Hodgkin's Disease Associated with Schilder's Disease
    Bateman , O. J.; Squires, G., and Thannhauser, S. J.
  • Malignant Lymphoma of the Uveal Tract
    Cooper , E. L., and Riker, J. L.
  • Cheratite in morbo di Hodgkin
    Francia , C.
  • Bilateral Symmetrical Exophthalmos Due to Retrobulbar Lymphosarcoma: Report of a Case
    Gross , P., and Votawa, G. J.
  • Uveitis Associated with Hodgkin's Disease: Report of a Case
    Kamellin , S.
  • Hodgkin's Disease of the Lid
    Kravitz , D.
  • Corneal Lesions in Hodgkin's Disease
    Matteucci , P.
  • One Case of Hodgkin's Disease Treated Over a Period of 6 Years with Recent Ocular Disturbances
    MacKechnie , H. N.
  • Round-Celled Sarcoma of the Anterior Mediastinum: Extensive Metastasis, Including the Brain, Both Choroid Coats, Oculo-Motor and Optic Nerves, and External Ocular Muscles
    Meigs , A. V., and de Schweinitz, G. E.
  • An Unusual Complication of Hodgkin's Disease
    Ridley , N. C.
  • Eye Conditions in Leukemia
    Sachs , B.
  • A Case of Uveo-Parotitis with Perivasculitis and Other Rare Symptoms
    von Bahr , G.
  • An Unusual Case of Hodgkin's Disease
    Avery , J. W., and Warren, J. W.
  • Bilateral Subconjunctival Lymphoid Infiltration: Report of a Case
    Saradarian , A. V.
  • A Case of Aleukemic Lymphosis Involving the Upper Lids, with Pathologic Findings
    Tooke , F. T.
  • Tumors of the Eye
    Reese , A. B.
  • Lymphomatoid Disease Involving the Eye and Its Adnexa
    McGavic , J. S.
  • Lymphomas and Leukemias
    Craver , L. F.
  • Lymphosarcoma: A Study of 196 Cases with Biopsy
    Sugarbaker , E. D., and Craver, L. F.
  • Malignant Lymphocytic Tumors of the Orbit
    Benedict , W. L., and Martens, T. G.
  • Intraorbital Tumors
    Forrest , A. W.
  • Orbital Tumours
    Iles , A. E., and Short, A. R.
  • Orbital Tumors
    Ingalls , R. G.
  • Lymphosarcoma of the Head and Neck
    Catlin , D.
  • Results of Treatment of Lymphosarcoma
    Stout , A. P.
  • Management of the Lymphomas
    Block , M., and Jacobson, L. O.

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