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Ocular Hypotensive Effects of N-Demethylated Carbachol on Open Angle Glaucoma

Ocular Hypotensive Effects of N-Demethylated Carbachol on Open Angle Glaucoma Abstract • Ocular hypotensive actions of N-demethylated carbachol hydrochloride (DMC) were studied in patients with open angle glaucoma; 1% pilocarpine hydrochloride solution was used as a reference. Although 1% pilocarpine seemed to be slightly more potent than 6% and 9% DMC solutions, DMC solutions were devoid of the noticeable side effects produced by pilocarpine. In all cases, maximum ocular hypotensive actions were observed six hours after the single-drop medication and were determined as 4.2, 4.6, and 4.8 mm Hg with 6% DMC, 9% DMC, and 1% pilocarpine, respectively. References 1. Trzeciakowski J, Chiou GCY: Pharmacological studies on N-demethylated carbachol . J Pharm Sci 1978;67:531-535.Crossref 2. Trzeciakowski J, Chiou GCY: Effects of N-demethylated carbachol on iris and ciliary muscles . J Pharm Sci 1980;69:332-334.Crossref 3. Chiou GCY, Trzeciakowski J, Gelatt KN: Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug . Invest Ophthalmol Vis Sci 1980;19:1198-1203. 4. Hung PT, Chang MY, Liu HK, et al: Effect of N-demethylated carbachol (DMC) on intraocular pressure , abstracted. Invest Ophthalmol Vis Sci, ARVO suppl , 1980, p 197. 5. Zimmerman TJ, Olander KW, Mandelkorn RM: Effect of a new topical cholinergic drug on intraocular pressure , abstracted. Invest Ophthalmol Vis Sci, ARVO suppl , 1980, p 197. 6. Hazard R, Cheymol J, Chabrier P, et al: Contribution de letude chemique et pharmacologique des aminoesters d'acids carbamiques et de leurs sels d'ammonium quaternairs . Bull Soc Chim Fr , 1961, pp 2087-2091. 7. Zimmerman TJ, Chiou GCY: Ocular hypotensive agents . Curr Concepts Ophthalmol 1976; 5:216-222. 8. Chiou GCY, Trzeciakowski J: Recent advances in cholinergic drugs for glaucoma . Curr Concepts Ophthalmol 1979;6:134-143. 9. Liu HK, Chiou GCY: Continuous, simultaneous, and instant display of aqueous humor dynamics with a microspectrophotometer and a sensitive drop counter . Exp Eye Res 1981;32:583-592.Crossref 10. Suedbergh B, Lutjen-Drecoll E, Ober M, et al: Cytochalasin B induced structural changes in the anterior ocular segment of the cynomolgus monkey . Invest Ophthalmol Vis Sci 1978;17:718-734. 11. Kaufman PL, Svedbergh B, Lutjen-Drecoll E: Medical trabeculocanalotomy in monkeys with cytochalsin B or EDTA . Ann Ophthalmol 1979; 11:795-796. 12. Bunke AJ, Bito LZ: The effect of topical disopropyl fluorophosphate (DFP) treatment on extraocular muscles , abstracted. Invest Ophthalmol Vis Sci, ARVO suppl , 1980, p 60. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Ocular Hypotensive Effects of N-Demethylated Carbachol on Open Angle Glaucoma

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030030264005
Publisher site
See Article on Publisher Site

Abstract

Abstract • Ocular hypotensive actions of N-demethylated carbachol hydrochloride (DMC) were studied in patients with open angle glaucoma; 1% pilocarpine hydrochloride solution was used as a reference. Although 1% pilocarpine seemed to be slightly more potent than 6% and 9% DMC solutions, DMC solutions were devoid of the noticeable side effects produced by pilocarpine. In all cases, maximum ocular hypotensive actions were observed six hours after the single-drop medication and were determined as 4.2, 4.6, and 4.8 mm Hg with 6% DMC, 9% DMC, and 1% pilocarpine, respectively. References 1. Trzeciakowski J, Chiou GCY: Pharmacological studies on N-demethylated carbachol . J Pharm Sci 1978;67:531-535.Crossref 2. Trzeciakowski J, Chiou GCY: Effects of N-demethylated carbachol on iris and ciliary muscles . J Pharm Sci 1980;69:332-334.Crossref 3. Chiou GCY, Trzeciakowski J, Gelatt KN: Reduction of intraocular pressure in glaucomatous dogs by a new cholinergic drug . Invest Ophthalmol Vis Sci 1980;19:1198-1203. 4. Hung PT, Chang MY, Liu HK, et al: Effect of N-demethylated carbachol (DMC) on intraocular pressure , abstracted. Invest Ophthalmol Vis Sci, ARVO suppl , 1980, p 197. 5. Zimmerman TJ, Olander KW, Mandelkorn RM: Effect of a new topical cholinergic drug on intraocular pressure , abstracted. Invest Ophthalmol Vis Sci, ARVO suppl , 1980, p 197. 6. Hazard R, Cheymol J, Chabrier P, et al: Contribution de letude chemique et pharmacologique des aminoesters d'acids carbamiques et de leurs sels d'ammonium quaternairs . Bull Soc Chim Fr , 1961, pp 2087-2091. 7. Zimmerman TJ, Chiou GCY: Ocular hypotensive agents . Curr Concepts Ophthalmol 1976; 5:216-222. 8. Chiou GCY, Trzeciakowski J: Recent advances in cholinergic drugs for glaucoma . Curr Concepts Ophthalmol 1979;6:134-143. 9. Liu HK, Chiou GCY: Continuous, simultaneous, and instant display of aqueous humor dynamics with a microspectrophotometer and a sensitive drop counter . Exp Eye Res 1981;32:583-592.Crossref 10. Suedbergh B, Lutjen-Drecoll E, Ober M, et al: Cytochalasin B induced structural changes in the anterior ocular segment of the cynomolgus monkey . Invest Ophthalmol Vis Sci 1978;17:718-734. 11. Kaufman PL, Svedbergh B, Lutjen-Drecoll E: Medical trabeculocanalotomy in monkeys with cytochalsin B or EDTA . Ann Ophthalmol 1979; 11:795-796. 12. Bunke AJ, Bito LZ: The effect of topical disopropyl fluorophosphate (DFP) treatment on extraocular muscles , abstracted. Invest Ophthalmol Vis Sci, ARVO suppl , 1980, p 60.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1982

References