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Ocular Findings in Multiple Myeloma: A Report of Two Cases

Ocular Findings in Multiple Myeloma: A Report of Two Cases Abstract The clinical and histologic findings in the eyes of two patients with multiple myeloma are described. In case 1, the patient had angle closure glaucoma that was possibly related to (1) relaxation of the zonular fibers and anterior displacement of the lens, (2) anterior displacement of the iris base by corona ciliaris cysts, (3) recurring iridocyclitis, or a combination of all three. In case 1, it was noted that the cysts were clear in vivo and that they became opaque after enucleation and fixation in formaldehyde solution. In case 2, due to the debilitated state of the patient, unilateral metastatic bacterial (pneumococcal) endophthalmitis and meningitis were superimposed on the commonly observed ocular manifestations of multiple myeloma. The associated ipsilateral disc edema appeared to be due to inflammatory causes rather than to the consequences of an intracranial or intraorbital plasmacytoma. References 1. Rodman HI, Font RL: Orbital involvement in multiple myeloma: Reivew of the literature and report of three cases . Arch Ophthalmol 87:30-35, 1972.Crossref 2. Bronstein M: Ocular involvement in multiple myeloma . Arch Ophthalmol 55:188-192, 1956.Crossref 3. Ashton N: Ocular changes in multiple myeloma . Arch Ophthalmol 73:487-494, 1965.Crossref 4. Clarke E: Ophthalmic complications of multiple myeloma . Br J Ophthalmol 39:233, 1955.Crossref 5. Wintrobe MM: Clinical Hematology , ed 6. Philadelphia, Lea & Febiger, 1967, pp 1188-1201. 6. Sanders TE, Podos MS, Rosenbaum LJ: Intraocular manifestations of multiple myeloma . Arch Ophthalmol 77:789-794, 1967.Crossref 7. Foos RY, Allen RA: Opaque cysts of the ciliary body (pars ciliaris retinae) . Arch Ophthalmol 77:559-568, 1967.Crossref 8. Johnson BL, Storey JD: Proteinaceous cyst of the ciliary epithelium . Arch Ophthalmol 84:166-171, 1970.Crossref 9. Sanders TE, Podos S: Pars plana cyst on multiple myeloma . Trans Am Acad Ophthalmol Otolaryngol 70:951, 1966. 10. Slansky HH, Bronstein M, Gartner S: Ciliary body cysts in multiple myeloma: Their relation to urethane, hyperproteinemia, and duration of the disease . Arch Ophthalmol 76:686-689, 1966.Crossref 11. Allen RA, Miller DH, Straatsma BR: Cysts of the posterior ciliary body (pars plara) . Arch Ophthalmol 66:302-313, 1961.Crossref 12. Johnson BL: Proteinaceous cysts of the ciliary epithelium: II. Their occurrence in nonmyelomatous hypergammaglogulinemic conditions . Arch Ophthalmol 84:171-175, 1970.Crossref 13. Holt JM, Gordon-Smith EC: Retinal abnormalities in diseases of the blood . Br J Ophthalmol 53:145, 1969.Crossref 14. Carr RE, Henkind P: Serum hyperviscosity . Am J Ophthalmol 56:23, 1963. 15. Myers BR, et al: Current patterns of infection in multiple myeloma . Am J Med 52:87, 1972.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Ocular Findings in Multiple Myeloma: A Report of Two Cases

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1974.03900060116006
Publisher site
See Article on Publisher Site

Abstract

Abstract The clinical and histologic findings in the eyes of two patients with multiple myeloma are described. In case 1, the patient had angle closure glaucoma that was possibly related to (1) relaxation of the zonular fibers and anterior displacement of the lens, (2) anterior displacement of the iris base by corona ciliaris cysts, (3) recurring iridocyclitis, or a combination of all three. In case 1, it was noted that the cysts were clear in vivo and that they became opaque after enucleation and fixation in formaldehyde solution. In case 2, due to the debilitated state of the patient, unilateral metastatic bacterial (pneumococcal) endophthalmitis and meningitis were superimposed on the commonly observed ocular manifestations of multiple myeloma. The associated ipsilateral disc edema appeared to be due to inflammatory causes rather than to the consequences of an intracranial or intraorbital plasmacytoma. References 1. Rodman HI, Font RL: Orbital involvement in multiple myeloma: Reivew of the literature and report of three cases . Arch Ophthalmol 87:30-35, 1972.Crossref 2. Bronstein M: Ocular involvement in multiple myeloma . Arch Ophthalmol 55:188-192, 1956.Crossref 3. Ashton N: Ocular changes in multiple myeloma . Arch Ophthalmol 73:487-494, 1965.Crossref 4. Clarke E: Ophthalmic complications of multiple myeloma . Br J Ophthalmol 39:233, 1955.Crossref 5. Wintrobe MM: Clinical Hematology , ed 6. Philadelphia, Lea & Febiger, 1967, pp 1188-1201. 6. Sanders TE, Podos MS, Rosenbaum LJ: Intraocular manifestations of multiple myeloma . Arch Ophthalmol 77:789-794, 1967.Crossref 7. Foos RY, Allen RA: Opaque cysts of the ciliary body (pars ciliaris retinae) . Arch Ophthalmol 77:559-568, 1967.Crossref 8. Johnson BL, Storey JD: Proteinaceous cyst of the ciliary epithelium . Arch Ophthalmol 84:166-171, 1970.Crossref 9. Sanders TE, Podos S: Pars plana cyst on multiple myeloma . Trans Am Acad Ophthalmol Otolaryngol 70:951, 1966. 10. Slansky HH, Bronstein M, Gartner S: Ciliary body cysts in multiple myeloma: Their relation to urethane, hyperproteinemia, and duration of the disease . Arch Ophthalmol 76:686-689, 1966.Crossref 11. Allen RA, Miller DH, Straatsma BR: Cysts of the posterior ciliary body (pars plara) . Arch Ophthalmol 66:302-313, 1961.Crossref 12. Johnson BL: Proteinaceous cysts of the ciliary epithelium: II. Their occurrence in nonmyelomatous hypergammaglogulinemic conditions . Arch Ophthalmol 84:171-175, 1970.Crossref 13. Holt JM, Gordon-Smith EC: Retinal abnormalities in diseases of the blood . Br J Ophthalmol 53:145, 1969.Crossref 14. Carr RE, Henkind P: Serum hyperviscosity . Am J Ophthalmol 56:23, 1963. 15. Myers BR, et al: Current patterns of infection in multiple myeloma . Am J Med 52:87, 1972.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1974

References