STUDY ONLINE FIRST Ocular Adverse Effects of Systemic Treatment With Isotretinoin Meira Neudorfer, MD; Inbal Goldshtein, MSc; Orna Shamai-Lubovitz, MD; Gabriel Chodick, PhD; Yuval Dadon; Varda Shalev, MD Objective: To examine whether isotretinoin therapy Results: In total, 13.8% of the isotretinoin group expe- could result in deleterious ocular effects, as previously rienced ocular AEs vs 9.6% of the isotretinoin-naive group described in case report studies. and 7.1% of the acne-free group. During a 1-year fol- low-up period, the isotretinoin group had significantly Design: Retrospective cohort study. higher risk for any ocular AEs (hazard ratio, 1.70; P.001) compared with the acne-free group. No such Setting: The study was conducted using the electronic increased risk was observed for the isotretinoin-naive medical databases of a large health maintenance organi- group. The isotretinoin group had higher relative risks zation in Israel. for inflammatory and structural AEs. Patients: The study population consisted of 14 682 ado- Conclusion: Isotretinoin use may be associated with lescents and young adults who were new users of isotreti- short-term ocular events, especially conjunctivitis, un- noin for acne and 2 age- and sex-matched comparison derscoring the importance of educating patients and care- groups (isotretinoin-naive patients with acne and acne- givers
JAMA Dermatology – American Medical Association
Published: Jul 1, 2012
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