Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Ocular Adverse Effects of Systemic Treatment With Isotretinoin

Ocular Adverse Effects of Systemic Treatment With Isotretinoin STUDY ONLINE FIRST Ocular Adverse Effects of Systemic Treatment With Isotretinoin Meira Neudorfer, MD; Inbal Goldshtein, MSc; Orna Shamai-Lubovitz, MD; Gabriel Chodick, PhD; Yuval Dadon; Varda Shalev, MD Objective: To examine whether isotretinoin therapy Results: In total, 13.8% of the isotretinoin group expe- could result in deleterious ocular effects, as previously rienced ocular AEs vs 9.6% of the isotretinoin-naive group described in case report studies. and 7.1% of the acne-free group. During a 1-year fol- low-up period, the isotretinoin group had significantly Design: Retrospective cohort study. higher risk for any ocular AEs (hazard ratio, 1.70; P.001) compared with the acne-free group. No such Setting: The study was conducted using the electronic increased risk was observed for the isotretinoin-naive medical databases of a large health maintenance organi- group. The isotretinoin group had higher relative risks zation in Israel. for inflammatory and structural AEs. Patients: The study population consisted of 14 682 ado- Conclusion: Isotretinoin use may be associated with lescents and young adults who were new users of isotreti- short-term ocular events, especially conjunctivitis, un- noin for acne and 2 age- and sex-matched comparison derscoring the importance of educating patients and care- groups (isotretinoin-naive patients with acne and acne- givers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Ocular Adverse Effects of Systemic Treatment With Isotretinoin

Download PDF
6 pages
Read Article

Loading next page...
 
/lp/american-medical-association/ocular-adverse-effects-of-systemic-treatment-with-isotretinoin-Q7lWBUT1SK
Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archdermatol.2012.352
pmid
22508771
Publisher site
See Article on Publisher Site

Abstract

STUDY ONLINE FIRST Ocular Adverse Effects of Systemic Treatment With Isotretinoin Meira Neudorfer, MD; Inbal Goldshtein, MSc; Orna Shamai-Lubovitz, MD; Gabriel Chodick, PhD; Yuval Dadon; Varda Shalev, MD Objective: To examine whether isotretinoin therapy Results: In total, 13.8% of the isotretinoin group expe- could result in deleterious ocular effects, as previously rienced ocular AEs vs 9.6% of the isotretinoin-naive group described in case report studies. and 7.1% of the acne-free group. During a 1-year fol- low-up period, the isotretinoin group had significantly Design: Retrospective cohort study. higher risk for any ocular AEs (hazard ratio, 1.70; P.001) compared with the acne-free group. No such Setting: The study was conducted using the electronic increased risk was observed for the isotretinoin-naive medical databases of a large health maintenance organi- group. The isotretinoin group had higher relative risks zation in Israel. for inflammatory and structural AEs. Patients: The study population consisted of 14 682 ado- Conclusion: Isotretinoin use may be associated with lescents and young adults who were new users of isotreti- short-term ocular events, especially conjunctivitis, un- noin for acne and 2 age- and sex-matched comparison derscoring the importance of educating patients and care- groups (isotretinoin-naive patients with acne and acne- givers

Journal

JAMA Dermatology – American Medical Association

Published: Jul 1, 2012

References

  • Management of acne vulgaris: an evidence-based update.
    Ingram, JR; Grindlay, DJ; Williams, HC
  • Dermatology.
    Bolognia, JLJJ; Rapini, RP
  • Ocular effects of oral retinoids.
    Lebowitz, MA; Berson, DS
  • Skin Pathology.
    Weedon, D; Strutton, G
  • Ocular side effects possibly associated with isotretinoin usage.
    Fraunfelder, FT; Fraunfelder, FW; Edwards, R
  • Ocular side effects associated with isotretinoin.
    Fraunfelder, FW
  • Ocular side effects associated with systemic isotretinoin.
    Oner, AF; Ferahbas, A; Karakucuk, S
  • Isotretinoin administration in treatment of acne vulgaris: a prospective study of the kind and extent of ocular complications.
    Egger, SF; Huber-Spitzy, V; Böhler, K; Scholda, C
  • Ocular side effects associated with 13- cis-retinoic acid therapy for acne vulgaris: clinical features, alterations of tearfilm and conjunctival flora.
    Egger, SF; Huber-Spitzy, V; Böhler, K
  • Lacrimal function and ocular complications in patients treated with systemic isotretinoin.
    Bozkurt, B; Irkeç, MT; Atakan, N; Orhan, M; Geyik, PO
  • The implementation of managed care for diabetes using medical informatics in a large preferred provider organization.
    Heymann, AD; Chodick, G; Halkin, H
  • Acute conjunctivitis: truth and misconceptions.
    O’Brien, TP; Jeng, BH; McDonald, M; Raizman, MB
  • Meibomian gland morphology and tear osmolarity: changes with Accutane therapy.
    Mathers, WD; Shields, WJ; Sachdev, MS; Petroll, WM; Jester, JV
  • A review of the Schirmer test for tear production.
    Wright, JC; Meger, GE
  • Pathogenesis of blepharoconjunctivitis complicating 13- cis-retinoic acid (isotretinoin) therapy in a laboratory model.
    Lambert, RW; Smith, RE
  • 13- cis-Retinoic acid inhibits sebaceous glands in animals and humans: planimetry and in-vitro autoradiography [abstract].
    Landthaler, M; Kummermehr, J; Wagner, A; Plewig, G
  • Isotretinoin in lacrimal gland fluid and tears.
    Rismondo, V; Ubels, JL
  • Meibomian gland function and giant papillary conjunctivitis.
    Mathers, WD; Billborough, M
  • Ocular surface changes and discomfort in patients with meibomian gland dysfunction.
    Shimazaki, J; Sakata, M; Tsubota, K
  • Association between meibomian gland changes and aging, sex, or tear function.
    Den, S; Shimizu, K; Ikeda, T; Tsubota, K; Shimmura, S; Shimazaki, J
  • Ocular water evaporation and the dry eye: a new measuring device.
    Mathers, WD; Binarao, G; Petroll, M
  • The international Workshop on Meibomian Gland Dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland.
    Knop, E; Knop, N; Millar, T; Obata, H; Sullivan, DA
  • Blepharitis.
    Bernardes, TF; Bonfioli, AA
  • The direct medical cost of cardiovascular diseases, hypertension, diabetes, cancer, pregnancy and female infertility in a large HMO in Israel.
    Chodick, G; Porath, A; Alapi, H

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial