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Ocular Adverse Effects of Systemic Treatment With Isotretinoin

Ocular Adverse Effects of Systemic Treatment With Isotretinoin STUDY ONLINE FIRST Ocular Adverse Effects of Systemic Treatment With Isotretinoin Meira Neudorfer, MD; Inbal Goldshtein, MSc; Orna Shamai-Lubovitz, MD; Gabriel Chodick, PhD; Yuval Dadon; Varda Shalev, MD Objective: To examine whether isotretinoin therapy Results: In total, 13.8% of the isotretinoin group expe- could result in deleterious ocular effects, as previously rienced ocular AEs vs 9.6% of the isotretinoin-naive group described in case report studies. and 7.1% of the acne-free group. During a 1-year fol- low-up period, the isotretinoin group had significantly Design: Retrospective cohort study. higher risk for any ocular AEs (hazard ratio, 1.70; P.001) compared with the acne-free group. No such Setting: The study was conducted using the electronic increased risk was observed for the isotretinoin-naive medical databases of a large health maintenance organi- group. The isotretinoin group had higher relative risks zation in Israel. for inflammatory and structural AEs. Patients: The study population consisted of 14 682 ado- Conclusion: Isotretinoin use may be associated with lescents and young adults who were new users of isotreti- short-term ocular events, especially conjunctivitis, un- noin for acne and 2 age- and sex-matched comparison derscoring the importance of educating patients and care- groups (isotretinoin-naive patients with acne and acne- givers http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Ocular Adverse Effects of Systemic Treatment With Isotretinoin

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archdermatol.2012.352
pmid
22508771
Publisher site
See Article on Publisher Site

Abstract

STUDY ONLINE FIRST Ocular Adverse Effects of Systemic Treatment With Isotretinoin Meira Neudorfer, MD; Inbal Goldshtein, MSc; Orna Shamai-Lubovitz, MD; Gabriel Chodick, PhD; Yuval Dadon; Varda Shalev, MD Objective: To examine whether isotretinoin therapy Results: In total, 13.8% of the isotretinoin group expe- could result in deleterious ocular effects, as previously rienced ocular AEs vs 9.6% of the isotretinoin-naive group described in case report studies. and 7.1% of the acne-free group. During a 1-year fol- low-up period, the isotretinoin group had significantly Design: Retrospective cohort study. higher risk for any ocular AEs (hazard ratio, 1.70; P.001) compared with the acne-free group. No such Setting: The study was conducted using the electronic increased risk was observed for the isotretinoin-naive medical databases of a large health maintenance organi- group. The isotretinoin group had higher relative risks zation in Israel. for inflammatory and structural AEs. Patients: The study population consisted of 14 682 ado- Conclusion: Isotretinoin use may be associated with lescents and young adults who were new users of isotreti- short-term ocular events, especially conjunctivitis, un- noin for acne and 2 age- and sex-matched comparison derscoring the importance of educating patients and care- groups (isotretinoin-naive patients with acne and acne- givers

Journal

JAMA DermatologyAmerican Medical Association

Published: Jul 1, 2012

References

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