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Ochronotic Arthropathy

Ochronotic Arthropathy Abstract O'Brien and his colleagues1 recently reported on a review of the world literature on alkaptonuria, ochronosis, and ochronotic arthropathy. In 1859, Boedeker first used the word "alkapton" to describe a reducing substance in the urine of certain patients which had a strong affinity for alkali and caused the urine to become dark brown on standing. The reducing substance was later identified as homogentisic acid by Wolkow and Bauman in 1891. Virchow introduced the term "ochronosis" in 1866 to indicate a clinical disease seen in many young alkaptonuric patients. It was not until 1902 that Albrecht first realized that the three conditions were all various stages of the same disease entity. Alkaptonuria is an inborn error of metabolism usually inherited as an autosomal recessive gene. There is a wide geographic and racial distribution, but O'Brien and co-workers1 noted it especially in areas where there is a high incidence of References 1. O'Brien, W.M.; La Du, B.N.; and Bunim, J.J.: Biochemical, Pathologic, and Clinical Aspects of Alcaptonuria, Ochronosis and Ochronotic Arthropathy: Review of World Literature (1584-1962) , Amer J Med 34:813-838 ( (June) ) 1963.Crossref 2. La Du, B.N., et al: The Nature of the Defect in Tyrosine Metabolism in Alcaptonuria , J Biol Chem 230:251-260 ( (Jan) ) 1958. 3. Smith, H.P., and Smith, H.P., Jr.: Ochronosis: Report of Two Cases , Ann Intern Med 42:171-178 ( (Jan) ) 1955.Crossref 4. Zannoni, V.G.; Malawista, S.E.; and La Du, B.N.: The Role of Homogentisic Acid and Benzoquinoneacetic Acid in Experimental and Alcaptonuric Connective Tissue Pigmentation (Ochronosis) , abstracted, Fed Proc 21:168, 1962. 5. Brookler, M.I., et al: Alkaptonuria and Ochronosis: Further Experiences , Mayo Clin Proc 39:107-117 ( (Feb) ) 1964. 6. Martin, W.J., et al: Alkaptonuria: Report of 12 Cases , Ann Intern Med 42:1052-1064 ( (May) ) 1955.Crossref 7. Harrold, A.J.: Alkaptonuric Arthritis , J Bone Joint Surg (Brit) 38:532-538 ( (May) ) 1956. 8. Cervenansky, J.; Sitáj, S.; and Urbánek, T.: Alkaptonuria and Ochronosis , J Bone Joint Surg (Amer) 41:1169-1182 ( (Oct) ) 1959. 9. Oritz, A.C., and Neal, E.G.: Alkaptonuria and Ochronotic Arthritis , Clin Orthop 25:147-155, 1962. 10. Pomeranz, M.M.; Friedman, L.J.; and Tunick, I.S.: Roentgen Findings in Alkaptonuric Ochronosis , Radiology 37:295-302 ( (Sept) ) 1941.Crossref 11. Oppenheimer, B.S., and Kline, B.S.: Ochronosis , Arch Intern Med 29:732-747 ( (June) ) 1922.Crossref 12. Lichtenstein, L., and Kaplan, L.: Hereditary Ochronosis: Pathologic Changes Observed in Two Necropsied Cases , Amer J Path 30:99-116 ( (Jan) -Feb) 1954. 13. Milch, R.A.: Biochemical Studies on the Pathogenesis of Collagen Tissue Changes in Alcaptonuria , Clin Orthop 24:213-229, 1962. 14. Milch, R.A., and Robinson, R.A.: Studies of Alcaptonuria: Content and Density of the Water and Solid Phases of Ochronotic Cartilage , J Chronic Dis 12:409-416 ( (Oct) ) 1960.Crossref 15. O'Brien, W.M.; Banfield, W.C.; and Sokoloff, L.: Studies on the Pathogenesis of Ochronotic Arthropathy , Arthritis Rheum 4:137-152 ( (April) ) 1961.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1970.01340200103023
Publisher site
See Article on Publisher Site

Abstract

Abstract O'Brien and his colleagues1 recently reported on a review of the world literature on alkaptonuria, ochronosis, and ochronotic arthropathy. In 1859, Boedeker first used the word "alkapton" to describe a reducing substance in the urine of certain patients which had a strong affinity for alkali and caused the urine to become dark brown on standing. The reducing substance was later identified as homogentisic acid by Wolkow and Bauman in 1891. Virchow introduced the term "ochronosis" in 1866 to indicate a clinical disease seen in many young alkaptonuric patients. It was not until 1902 that Albrecht first realized that the three conditions were all various stages of the same disease entity. Alkaptonuria is an inborn error of metabolism usually inherited as an autosomal recessive gene. There is a wide geographic and racial distribution, but O'Brien and co-workers1 noted it especially in areas where there is a high incidence of References 1. O'Brien, W.M.; La Du, B.N.; and Bunim, J.J.: Biochemical, Pathologic, and Clinical Aspects of Alcaptonuria, Ochronosis and Ochronotic Arthropathy: Review of World Literature (1584-1962) , Amer J Med 34:813-838 ( (June) ) 1963.Crossref 2. La Du, B.N., et al: The Nature of the Defect in Tyrosine Metabolism in Alcaptonuria , J Biol Chem 230:251-260 ( (Jan) ) 1958. 3. Smith, H.P., and Smith, H.P., Jr.: Ochronosis: Report of Two Cases , Ann Intern Med 42:171-178 ( (Jan) ) 1955.Crossref 4. Zannoni, V.G.; Malawista, S.E.; and La Du, B.N.: The Role of Homogentisic Acid and Benzoquinoneacetic Acid in Experimental and Alcaptonuric Connective Tissue Pigmentation (Ochronosis) , abstracted, Fed Proc 21:168, 1962. 5. Brookler, M.I., et al: Alkaptonuria and Ochronosis: Further Experiences , Mayo Clin Proc 39:107-117 ( (Feb) ) 1964. 6. Martin, W.J., et al: Alkaptonuria: Report of 12 Cases , Ann Intern Med 42:1052-1064 ( (May) ) 1955.Crossref 7. Harrold, A.J.: Alkaptonuric Arthritis , J Bone Joint Surg (Brit) 38:532-538 ( (May) ) 1956. 8. Cervenansky, J.; Sitáj, S.; and Urbánek, T.: Alkaptonuria and Ochronosis , J Bone Joint Surg (Amer) 41:1169-1182 ( (Oct) ) 1959. 9. Oritz, A.C., and Neal, E.G.: Alkaptonuria and Ochronotic Arthritis , Clin Orthop 25:147-155, 1962. 10. Pomeranz, M.M.; Friedman, L.J.; and Tunick, I.S.: Roentgen Findings in Alkaptonuric Ochronosis , Radiology 37:295-302 ( (Sept) ) 1941.Crossref 11. Oppenheimer, B.S., and Kline, B.S.: Ochronosis , Arch Intern Med 29:732-747 ( (June) ) 1922.Crossref 12. Lichtenstein, L., and Kaplan, L.: Hereditary Ochronosis: Pathologic Changes Observed in Two Necropsied Cases , Amer J Path 30:99-116 ( (Jan) -Feb) 1954. 13. Milch, R.A.: Biochemical Studies on the Pathogenesis of Collagen Tissue Changes in Alcaptonuria , Clin Orthop 24:213-229, 1962. 14. Milch, R.A., and Robinson, R.A.: Studies of Alcaptonuria: Content and Density of the Water and Solid Phases of Ochronotic Cartilage , J Chronic Dis 12:409-416 ( (Oct) ) 1960.Crossref 15. O'Brien, W.M.; Banfield, W.C.; and Sokoloff, L.: Studies on the Pathogenesis of Ochronotic Arthropathy , Arthritis Rheum 4:137-152 ( (April) ) 1961.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1970

References