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Observations on the Experimental Use of Radioactive Isotopes Within the Larynx of the Dog: Notes on the Submucosal Compartments of the Human Larynx

Observations on the Experimental Use of Radioactive Isotopes Within the Larynx of the Dog: Notes... Abstract Studies on the local spread of fluids injected into the larynx, carried out as a preliminary investigation to the use of radioisotopes, have revealed interesting anatomical data pertaining to the presence of isolated submucosal laryngeal compartments. These are herein reported. Whether the use of radioisotopes will be effective in the treatment of laryngeal cancer is not known, but before it is attempted, certain basic facts should be established. These include the direction and degree of spread of fluids injected into a particular site, and the effects of locally injected radioactive isotopes on the normal structures of the larynx. A technique needs to be developed for the injection of the isotopes to assure effective distribution throughout the involved area and to avoid contamination. Determination of the length of time that the radioisotope will remain within the larynx is of particular importance, since up to now it has not been known References 1. Designed by Dean P. Gamble and Raymond L. Libby, University of California Medical School at Los Angeles. 2. Pressman, J. J.: Submucosal Compartmentation of the Larynx , Ann. Otol. Rhin. & Laryng. 65:766-771, 1956. 3. Hajek, M.: Anatomische Untersuchungen über das Larynxödem , Arch. klin. Chir. 42:46-93, 1891. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

Observations on the Experimental Use of Radioactive Isotopes Within the Larynx of the Dog: Notes on the Submucosal Compartments of the Human Larynx

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References (4)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1957.03830260036004
Publisher site
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Abstract

Abstract Studies on the local spread of fluids injected into the larynx, carried out as a preliminary investigation to the use of radioisotopes, have revealed interesting anatomical data pertaining to the presence of isolated submucosal laryngeal compartments. These are herein reported. Whether the use of radioisotopes will be effective in the treatment of laryngeal cancer is not known, but before it is attempted, certain basic facts should be established. These include the direction and degree of spread of fluids injected into a particular site, and the effects of locally injected radioactive isotopes on the normal structures of the larynx. A technique needs to be developed for the injection of the isotopes to assure effective distribution throughout the involved area and to avoid contamination. Determination of the length of time that the radioisotope will remain within the larynx is of particular importance, since up to now it has not been known References 1. Designed by Dean P. Gamble and Raymond L. Libby, University of California Medical School at Los Angeles. 2. Pressman, J. J.: Submucosal Compartmentation of the Larynx , Ann. Otol. Rhin. & Laryng. 65:766-771, 1956. 3. Hajek, M.: Anatomische Untersuchungen über das Larynxödem , Arch. klin. Chir. 42:46-93, 1891.

Journal

A.M.A. Archives of Otolaryngology – American Medical Association

Published: Aug 1, 1957

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