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OBSERVATIONS ON INDUCED THIAMINE (VITAMIN B1) DEFICIENCY IN MAN

OBSERVATIONS ON INDUCED THIAMINE (VITAMIN B1) DEFICIENCY IN MAN Abstract Reports of controlled observations on induced thiamine (vitamin B1) deficiency in human beings have been few,1 and in only two of these reports1c,d has the restriction of vitamins been limited to thiamine. One of these studies1d was reported by three of us (Williams, Mason and Smith) in December 1939. In that study, 4 young women for twenty-one weeks received a diet which was more deficient in vitamin B1 than commonly is reported in association with the syndrome of beriberi. This diet was made adequate in vitamin A, ascorbic acid, proteins and minerals and in addition was supplemented with crystalline preparations of riboflavin and nicotinic acid. The delayed development of symptoms and failure of the subjects to show the classic signs of beriberi prompted repetition of the study with other subjects. Also it seemed desirable to provide more adequately for the factors of the vitamin B complex other than thiamine. For References 1. Cowgill, G. R.: Human Requirements for Vitamin Bi, in The Vitamins: A Symposium Arranged Under the Auspices of the Council on Pharmacy and Chemistry and the Council on Foods of the American Medical Association , Chicago, American Medical Association, 1939, chap. 12 , pp. 229-248. 2. Elsom, K. O.: Experimental Study of Clinical Vitamin B Deficiency , J. Clin. Investigation 14: 40-51 ( (Jan.) ) 1935.Crossref 3. Jolliffe, N.; Goodhart, R.; Gennis, J., and Cline, J. K.: The Experimental Production of Vitamin Bi Deficiency in Normal Subjects: The Dependence of the Urinary Excretion of Thiamin on the Dietary Intake of Vitamin Bi , Am. J. M. Sc. 198:198-211 ( (Aug.) ) 1939.Crossref 4. Williams, R. D.; Mason, H. L., and Smith, B. F.: Induced Vitamin Bi Deficiency in Human Subjects , Proc. Staff Meet., Mayo Clin. 14:787-793 ( (Dec. 13) ) 1939. 5. Elsom, K. O.; Lukens, F. D. W.; Montgomery, E. H., and Jonas, L.: Metabolic Disturbances in Experimental Human Vitamin B Deficiency , J. Clin. Investigation 19:153-161 ( (Jan.) ) 1940.Crossref 6. Except in case 3, in which deformity of the left leg was present owing to anterior poliomyelitis during childhood. 7. Hennessy, D. J., and Cerecedo, L. R.: The Determination of Free and Phosphorylated Thiamin by a Modified Thiochrome Assay , J. Am. Chem. Soc. 61:179-183 ( (Jan.) ) 1939.Crossref 8. This work was made possible by the assistance of Miss Phyllis Newman and Miss Margaret Pewters. 9. Miller, B. F., and Van Slyke, D. D.: A Direct Microtitration Method for Blood Sugar , J. Biol. Chem. 114:583-595 ( (July) ) 1936. 10. Clift, F. P., and Cook, R. P.: A Method for Determination of Some Biologically Important Aldehydes and Ketones, with Special Reference to Pyruvic Acid and Methylglyoxal , Biochem. J. 26:1788-1799, 1932. 11. Miller, B. F., and Muntz, J. A.: A Method for the Estimation of Ultramicroquantities of Lactic Acid , J. Biol. Chem. 126:413-421 ( (Nov.) ) 1938. 12. Kagawa, S.: Studies on the Relation of Neuritis Axialis to Beriberi in Japan , Jap. J. M. Sc., VIII, Int. Med., Pediat. & Psychiat. 5:1-60 ( (Dec.) ) 1938. 13. Wilson, G.: Neurasthenia , in Musser, J. H.: Internal Medicine: Its Theory and Practice in Contributions by American Authors , ed. 3, Philadelphia, Lea & Febiger, 1938, p. 1235. 14. McLester, J. S.: Borderline States of Nutritive Failure , J. A. M. A. 112:2110-2114 ( (May 27) ) 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

OBSERVATIONS ON INDUCED THIAMINE (VITAMIN B1) DEFICIENCY IN MAN

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Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1940.00190160002001
Publisher site
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Abstract

Abstract Reports of controlled observations on induced thiamine (vitamin B1) deficiency in human beings have been few,1 and in only two of these reports1c,d has the restriction of vitamins been limited to thiamine. One of these studies1d was reported by three of us (Williams, Mason and Smith) in December 1939. In that study, 4 young women for twenty-one weeks received a diet which was more deficient in vitamin B1 than commonly is reported in association with the syndrome of beriberi. This diet was made adequate in vitamin A, ascorbic acid, proteins and minerals and in addition was supplemented with crystalline preparations of riboflavin and nicotinic acid. The delayed development of symptoms and failure of the subjects to show the classic signs of beriberi prompted repetition of the study with other subjects. Also it seemed desirable to provide more adequately for the factors of the vitamin B complex other than thiamine. For References 1. Cowgill, G. R.: Human Requirements for Vitamin Bi, in The Vitamins: A Symposium Arranged Under the Auspices of the Council on Pharmacy and Chemistry and the Council on Foods of the American Medical Association , Chicago, American Medical Association, 1939, chap. 12 , pp. 229-248. 2. Elsom, K. O.: Experimental Study of Clinical Vitamin B Deficiency , J. Clin. Investigation 14: 40-51 ( (Jan.) ) 1935.Crossref 3. Jolliffe, N.; Goodhart, R.; Gennis, J., and Cline, J. K.: The Experimental Production of Vitamin Bi Deficiency in Normal Subjects: The Dependence of the Urinary Excretion of Thiamin on the Dietary Intake of Vitamin Bi , Am. J. M. Sc. 198:198-211 ( (Aug.) ) 1939.Crossref 4. Williams, R. D.; Mason, H. L., and Smith, B. F.: Induced Vitamin Bi Deficiency in Human Subjects , Proc. Staff Meet., Mayo Clin. 14:787-793 ( (Dec. 13) ) 1939. 5. Elsom, K. O.; Lukens, F. D. W.; Montgomery, E. H., and Jonas, L.: Metabolic Disturbances in Experimental Human Vitamin B Deficiency , J. Clin. Investigation 19:153-161 ( (Jan.) ) 1940.Crossref 6. Except in case 3, in which deformity of the left leg was present owing to anterior poliomyelitis during childhood. 7. Hennessy, D. J., and Cerecedo, L. R.: The Determination of Free and Phosphorylated Thiamin by a Modified Thiochrome Assay , J. Am. Chem. Soc. 61:179-183 ( (Jan.) ) 1939.Crossref 8. This work was made possible by the assistance of Miss Phyllis Newman and Miss Margaret Pewters. 9. Miller, B. F., and Van Slyke, D. D.: A Direct Microtitration Method for Blood Sugar , J. Biol. Chem. 114:583-595 ( (July) ) 1936. 10. Clift, F. P., and Cook, R. P.: A Method for Determination of Some Biologically Important Aldehydes and Ketones, with Special Reference to Pyruvic Acid and Methylglyoxal , Biochem. J. 26:1788-1799, 1932. 11. Miller, B. F., and Muntz, J. A.: A Method for the Estimation of Ultramicroquantities of Lactic Acid , J. Biol. Chem. 126:413-421 ( (Nov.) ) 1938. 12. Kagawa, S.: Studies on the Relation of Neuritis Axialis to Beriberi in Japan , Jap. J. M. Sc., VIII, Int. Med., Pediat. & Psychiat. 5:1-60 ( (Dec.) ) 1938. 13. Wilson, G.: Neurasthenia , in Musser, J. H.: Internal Medicine: Its Theory and Practice in Contributions by American Authors , ed. 3, Philadelphia, Lea & Febiger, 1938, p. 1235. 14. McLester, J. S.: Borderline States of Nutritive Failure , J. A. M. A. 112:2110-2114 ( (May 27) ) 1939.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1940

References