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Research Original Investigation Obesity and Postmenopausal Invasive Breast Cancer Risk Invited Commentary Narrowing the Focus Clifford Hudis, MD; Andrew Dannenberg, MD In large part, obesity represents the end result of excess calo- The article by Neuhouser et al in this issue of JAMA On- rie consumption. Because overweight or obesity has always cology is an important contribution. It extends and refines our been an issue, some may ask why we are focusing on it now. understanding of one of the risks of overweight and obesity: A unique change is occurring increased incidence of the most common manifestation of on a global scale. Over- breast cancer (postmenopausal, hormone receptor–positive Author Audio Interview at weight and obesity are more disease). This team of investigators used data from the Wo- jamaoncology.com prevalent than ever in re- men’s Health Initiative clinical trials (WHI) drawn from more corded history, rates have than 67 000 women older than 50 years (but <80 years) from Related article page 611 been rising in almost every 1993 to 1998 who were followed at 40 US centers for a median society in which medical rec- of 13 years. They adjudicated all cases of new primary breast ords are available,
JAMA Oncology – American Medical Association
Published: Aug 1, 2015
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