Abstract Production of cataract in albino rats placed on a diet deficient in riboflavin (vitamin G, or B2) was first reported by Day, Langston and O'Brien1 in 1931. Confirmation of these results has been obtained by O'Brien2 and Yudkin.3 Langston, Day and Cosgrove4 were able to produce this form of cataract in albino mice, and Langston and Day,5 in Norway rats. Langston and Day6 found that development of cataract in albino rats was arrested when vitamin G was supplied in the form of skim milk powder. The diet used by these investigators in this work on cataract was the "vitamin B-complex deficient diet" of Sherman and Spohn,7 modified by incorporating an 80 per cent alcoholic extract of rice polish.1 The incidence of cataract was consistently close to 100 per cent, the average time of appearance of the cataract being about ten weeks. References 1. Day, P. L.; Langston, W. C., and O'Brien, C. S.: Cataract and Other Ocular Changes in Vitamin G Deficiency , Am. J. Ophth. 14:1005, 1931. 2. O'Brien, C. S.: Experimental Cataract in Vitamin G Deficiency , Arch. Ophth. 8:880 ( (Dec.) ) 1932.Crossref 3. Yudkin, A. M.: Ocular Disturbances Produced in Experimental Animals by Dietary Changes: Clinical Implications , J. A. M. A. 101:921 ( (Sept. 16) ) 1933.Crossref 4. Langston, W. C.; Day, P. L., and Cosgrove, K. W.: Cataract in the Albino Mouse Resulting from a Deficiency of Vitamin G (B2) , Arch. Ophth. 10:508 ( (Oct.) ) 1933.Crossref 5. Langston, W. C., and Day, P. L.: Nutritional Cataract in the Norway Rat (Mus Norvegicus) , South. M. J. 26:128, 1933.Crossref 6. Langston, W. C., and Day, P. L.: The Arrest of Nutritional Cataract in the Albino Rat by the Use of Vitamin G (B2) , South. M. J. 27:170, 1934.Crossref 7. Sherman, H. C., and Spohn, A.: Critical Investigation and an Application of the Rat-Growth Method for the Study of Vitamin B , J. Am. Chem. Soc. 45:2719, 1923.Crossref 8. Day, P. L., and Langston, W. C.: Further Experiments with Cataract in Albino Rats Resulting from the Withdrawal of Vitamin G (B2) from the Diet , J. Nutrition 7:97, 1934. 9. Day, P. L.; Darby, W. J., and Langston, W. C.: The Identity of Flavin with the Cataract-Preventive Factor , J. Nutrition 13:389, 1937. 10. Day, P. L.; Darby, W. J., and Cosgrove, K. W.: The Arrest of Nutritional Cataract by the Use of Riboflavin , J. Nutrition 15:83, 1938. 11. J. A. M. A. 108:1340 [ (April 17) ] 1937 12. Bourne, M. C., and Pyke, M. A.: The Occurrence of Cataract in Rats Fed on Diets Deficient in Vitamin B2 , Biochem. J. 29:1865, 1935. 13. Bourne, M. C.: Metabolic Factors in Cataract Production , Physiol. Rev. 17:1, 1937. 14. György, P.: Investigations on the Vitamin B2 Complex: I. The Differentiation of Lactoflavin and the "Rat Antipellagra" Factor , Biochem. J. 29:741, 1935. 15. Personal communication to the authors. 16. Sen, K.; Das, N., and Guha, B. C.: Pathological Changes in the Eye in Experimental Vitamin B2 Deficiency , Science & Cult. 1:59, 1935 17. abstracted, Chem. Abstr. 29:7400, 1935. 18. Jansen, B. C. P.: Cataract-Producing Diets , Acta brev. Neerland. 5:165, 1935. 19. Kellogg, M.: Appearance of Cataract in Rats on a Vitamin B2-Low Diet , Proc. South Dakota Acad. Sc. 17:21, 1937. 20. Mitchell, H. S., and Dodge, W. M.: Cataract in Rats Fed on High Lactose Rations , J. Nutrition 9:37, 1935. 21. Mitchell, H. S.: Cataract in Rats Fed on Galactose , J. Nutrition (supp.) 9:14, 1935. 22. Yudkin, A. M., and Arnold, C. H.: Cataract Formation in Rats Fed on a Diet Containing Galactose , Proc. Soc. Exper. Biol. & Med. 32:836, 1935. 23. Day, P. L.: Blood Sugar in Rats Rendered Cataractous by Dietary Procedures , J. Nutrition 12:395, 1936. 24. Bellows, J. G.: Biochemistry of the Lens: IX. Influence of Vitamin C and Sulfhydryls on the Production of Galactose Cataract , Arch. Ophth. 16:762 ( (Nov.) ) 1936. 25. Morgan, A. F., and Cook, B. B.: Cataract- and Dermatitis-Producing Nutritional Factors , Proc. Soc. Exper. Biol. & Med. 34:281, 1936. 26. Supplied by Dr. P. L. Day. 27. Supplied by the S. M. A. Corporation. This casein will subsequently be designated S. M. A. casein. 28. McCollum, E. V., and Simmonds, N.: A Study of the Dietary Essential, Water-Soluble B, in Relation to Its Solubility and Stability Towards Reagents , J. Biol. Chem. 33:55, 1918. 29. A commercial brand of casein sold by the Casein Company of America, Inc. 30. Osborne, T. B., and Mendel, L. B.: The Nutritive Value of the Wheat Kernel and Its Milling Products , J. Biol. Chem. 37:557, 1919. 31. The drawings in figures 1 and 4 have been made by Miss Theodora Bergsland, of the Institute of Pathology, Western Reserve University. The photograph (fig. 2) and the accompanying photomicrograph (fig. 3) have been supplied by that Institute. 32. Birch, T. W.; György, P., and Harris, L. J.: The Vitamin B2 Complex. Differentiation of the Antiblacktongue and the "P.-P." Factors from Lactoflavin and Vitamin B6 (So-Called "Rat Pellagra" Factor) , Biochem. J. 29:2830, 1935. 33. Sebrell, W. H.; Onstott, R. H., and Hunt, D. J.: The Treatment of Black-Tongue with a Preparation Containing the "Filtrate Factor," and Evidence of Riboflavin Deficiency in Dogs , Pub. Health Rep. 52:427, 1937. 34. Mitchell, H. S., and Cook, G. M.: Galactose Cataract in Rats: Factors Influencing Progressive and Regressive Changes , Arch. Ophth. 19:22 ( (Jan.) ) 1938. 35. A. H. Smith and F. C. Bing ( Improved Rate of Growth of Stock Albino Rats , J. Nutrition 1:179, 1928) 36. Day, P. L.: Blood Sugar in Rats in Which Cataract Was Produced by a Vitamin G-Deficient Diet and by a Lactose-Containing Diet , J. Biol. Chem. 109: xxvi, 1935. 37. Bellows, J. G., and Rosner, L.: Studies on Galactose Cataract , Am. J. Ophth. 20:1109, 1937. 38. Kirby, D. B.; Estey, K., and Wiener, R. v. E.: A Study of the Effect of Changes in the Nutrient Medium on Lens Epithelium, Cultivated "in Vitro," Tr. Am. Acad. Ophth. 37:196, 1932. 39. Bellows and Rosner,35 p. 1112.
Archives of Ophthalmology – American Medical Association
Published: Feb 1, 1939
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