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Nutrient Malabsorption in the Zollinger-Ellison Syndrome: Normalization During Long-term Cimetidine Therapy

Nutrient Malabsorption in the Zollinger-Ellison Syndrome: Normalization During Long-term... Abstract • Nutrient malabsorption occasionally occurs in the setting of acid hypersecretion with the Zollinger-Ellison syndrome. Previous incomplete reversal of this malabsorption with therapy has probably been due to inadequate suppression of acid secretion with medical therapy or disturbances of anatomy and physiology occurring as a result of surgical therapy. A patient whose primary manifestations of this syndrome were nutrient malabsorption and diarrhea was afforded complete reversal of the malabsorption on receiving long-term cimetidine therapy. This effective medical therapy has thus demonstrated that nutrient malabsorption in the Zollinger-Ellison syndrome is due solely to the deleterious effects of acid hypersecretion. (Arch Intern Med 1983;143:349-351) References 1. Isenberg JI, Walsh, JH, Grossman MI: Zollinger-Ellison syndrome. Gastroenterology 1973;65:140-165. 2. McGuigan JE: Role of gastrin in hypersecretory disorders in man. Ann Rev Med 1974;25:233-249.Crossref 3. Donaldson RM, Vom Eigen PR, Dwight RW: Gastric hypersecretion, peptic ulceration and islet-cell tumor of the pancreas (the Zollinger-Ellison syndrome). N Engl J Med 1957;257:965-970.Crossref 4. Shimoda SS, Saunders DR, Rubin CE: The Zollinger-Ellison syndrome with steatorrhea: II. The mechanisms of fat and vitamin B12 malabsorption. Gastroenterology 1968;55:705-723. 5. Mansbach CM, Wilkins RM, Dobbins WO, et al: Intestinal mucosal function and structure in the steatorrhea of Zollinger-Ellison syndrome. Arch Intern Med 1968;121:487-494.Crossref 6. Go VLW, Poley JR, Hofmann AF, et al: Disturbances in fat digestion induced by acidic jejunal pH due to gastric hypersecretion in man. Gastroenterology 1970;58:638-646. 7. Shimoda SS, Rubin CE: The Zollinger-Ellison syndrome with steatorrhea: I. Anticholinergic treatment followed by total gastrectomy and colonic interposition. Gastroenterology 1968;55:695-704. 8. King CE, Toskes PP: Malabsorption following gastric resection , in Buskin FL, Woodward ER (eds): Postgastrectomy Syndromes . Philadelphia, WB Saunders Co, 1976, pp 129-146. 9. Moshal MC, Broitman SA, Zamcheck N: Gastrin and absorption: A review. Am J Clin Nutr 1970;23:336-342. 10. Wright HK, Hersh T, Floch MH, et al: Impaired intestinal absorption in the Zollinger-Ellison syndrome independent of gastric hypersecretion. Am J Surg 1970;119:250-253.Crossref 11. Roe JH, Rice EW: A photometric method for the determination of free pentoses in animal tissue. J Biol Chem 1947;173:507-512. 12. Van de Kamer JR, Huinink HTB, Weyers HA: Rapid method for the determination of fat in feces. J Biol Chem 1949;177:347-355. 13. Schilling RF: Intrinsic factor studies: II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J Lab Clin Med 1953;42:860-866. 14. McGuigan JE, Wolfe MM: Secretin injection test in the diagnosis of gastrinoma. Gastroenterology 1980;79:1324-1331. 15. Dreiling DA, Greenstein A: Pancreatic function in patients with Zollinger-Ellison syndrome. Am J Gastroenterol 1972;58:66-72. 16. Cortot A, Fleming CR, Malagelada JR: Improved nutrient absorption after cimetidine in short-bowel syndrome with gastric hypersecretion. N Engl J Med 1979;300:79-80.Crossref 17. Murphy JP, King DR, Dubois A: Treatment of gastric hypersecretion with cimetidine in the short-bowel syndrome. N Engl J Med 1979;300:80-81.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Nutrient Malabsorption in the Zollinger-Ellison Syndrome: Normalization During Long-term Cimetidine Therapy

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350020175033
Publisher site
See Article on Publisher Site

Abstract

Abstract • Nutrient malabsorption occasionally occurs in the setting of acid hypersecretion with the Zollinger-Ellison syndrome. Previous incomplete reversal of this malabsorption with therapy has probably been due to inadequate suppression of acid secretion with medical therapy or disturbances of anatomy and physiology occurring as a result of surgical therapy. A patient whose primary manifestations of this syndrome were nutrient malabsorption and diarrhea was afforded complete reversal of the malabsorption on receiving long-term cimetidine therapy. This effective medical therapy has thus demonstrated that nutrient malabsorption in the Zollinger-Ellison syndrome is due solely to the deleterious effects of acid hypersecretion. (Arch Intern Med 1983;143:349-351) References 1. Isenberg JI, Walsh, JH, Grossman MI: Zollinger-Ellison syndrome. Gastroenterology 1973;65:140-165. 2. McGuigan JE: Role of gastrin in hypersecretory disorders in man. Ann Rev Med 1974;25:233-249.Crossref 3. Donaldson RM, Vom Eigen PR, Dwight RW: Gastric hypersecretion, peptic ulceration and islet-cell tumor of the pancreas (the Zollinger-Ellison syndrome). N Engl J Med 1957;257:965-970.Crossref 4. Shimoda SS, Saunders DR, Rubin CE: The Zollinger-Ellison syndrome with steatorrhea: II. The mechanisms of fat and vitamin B12 malabsorption. Gastroenterology 1968;55:705-723. 5. Mansbach CM, Wilkins RM, Dobbins WO, et al: Intestinal mucosal function and structure in the steatorrhea of Zollinger-Ellison syndrome. Arch Intern Med 1968;121:487-494.Crossref 6. Go VLW, Poley JR, Hofmann AF, et al: Disturbances in fat digestion induced by acidic jejunal pH due to gastric hypersecretion in man. Gastroenterology 1970;58:638-646. 7. Shimoda SS, Rubin CE: The Zollinger-Ellison syndrome with steatorrhea: I. Anticholinergic treatment followed by total gastrectomy and colonic interposition. Gastroenterology 1968;55:695-704. 8. King CE, Toskes PP: Malabsorption following gastric resection , in Buskin FL, Woodward ER (eds): Postgastrectomy Syndromes . Philadelphia, WB Saunders Co, 1976, pp 129-146. 9. Moshal MC, Broitman SA, Zamcheck N: Gastrin and absorption: A review. Am J Clin Nutr 1970;23:336-342. 10. Wright HK, Hersh T, Floch MH, et al: Impaired intestinal absorption in the Zollinger-Ellison syndrome independent of gastric hypersecretion. Am J Surg 1970;119:250-253.Crossref 11. Roe JH, Rice EW: A photometric method for the determination of free pentoses in animal tissue. J Biol Chem 1947;173:507-512. 12. Van de Kamer JR, Huinink HTB, Weyers HA: Rapid method for the determination of fat in feces. J Biol Chem 1949;177:347-355. 13. Schilling RF: Intrinsic factor studies: II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J Lab Clin Med 1953;42:860-866. 14. McGuigan JE, Wolfe MM: Secretin injection test in the diagnosis of gastrinoma. Gastroenterology 1980;79:1324-1331. 15. Dreiling DA, Greenstein A: Pancreatic function in patients with Zollinger-Ellison syndrome. Am J Gastroenterol 1972;58:66-72. 16. Cortot A, Fleming CR, Malagelada JR: Improved nutrient absorption after cimetidine in short-bowel syndrome with gastric hypersecretion. N Engl J Med 1979;300:79-80.Crossref 17. Murphy JP, King DR, Dubois A: Treatment of gastric hypersecretion with cimetidine in the short-bowel syndrome. N Engl J Med 1979;300:80-81.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1983

References