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NORMAL HEMATOLOGIC STANDARDS

NORMAL HEMATOLOGIC STANDARDS Abstract This paper presents a summary of the results of a series of hematologic studies, including all the commonly used procedures, on over 500 healthy persons of both sexes ranging from young children to adults. Details of these studies1 together with reviews of the literature will appear elsewhere. The development of a uniform system of methods for the hematologic study of oxalated venous blood made this investigation possible. These methods are simple enough for routine clinical use, but they approach research methods in accuracy. Erythrocyte counts, hemoglobin values, hemoglobin coefficients and color indexes are reported for 626 persons; cell volumes, volume coefficients and volume and saturation indexes, for 583; reticulocyte counts, for 476; leukocyte and differential counts, for 597, and sedimentation rates, for 853. The ages of the subjects ranged from 4 years to past 30. SUBJECTS All the subjects lived in or near Portland, Ore., at an elevation of References 1. Mrs. Mable Wilhelm Osgood, Mr. Russell L. Baker and Miss Inez Brownlee collaborated in these studies. 2. Dr. Helen Cary and Dr. Frank Mount cooperated in securing suitable subjects from the schools and orphan asylums. 3. Many reports of so-called normal values have been based on studies of patients with minor illnesses in clinics or hospitals. This practice is to be condemned. It probably accounts for some of the differences between the standards determined by my associates and me and those in general use. 4. Osgood, E. E.; Haskins, H. D.; Trotman, F. E., and Mathieu, A.: A Uniform System of Hematologic Methods for Use with Oxalated Venous Blood: A Simplification of the Osgood-Haskins Hemoglobin Method; A Rapid Method for Determination of the Sedimentation Rate of the Red Cells with Results in Health and Disease , J. Lab. & Clin. Med. 16:476 ( (Feb.) ) 1931. 5. Osgood, E. E.: A Textbook of Laboratory Diagnosis , Philadelphia, P. Blakiston's Son & Co., ed. 2, 1935, pp. 192 and 378 6. Relation Between Cell Count, Cell Volume and Hemoglobin Content of Venous Blood of Normal Young Women , Arch. Int. Med. 39:643 ( (May) ) 1927. 7. Osgood, E. E.: Hemoglobin, Color Index, Saturation Index and Volume Index Standards , Arch. Int. Med. 37:685 ( (May) ) 1926 8. Tables for Calculation of Color Index, Volume Index and Saturation Index Based on Recently Determined Standards , J. Lab. & Clin. Med. 12:899 ( (June) ) 1927. 9. Osgood, E. E., and Wilhelm, Mable M.: Reticulocytes , J. Lab. & Clin. Med. 19:1129 ( (July) ) 1934. 10. Osgood, E. E.; Baker, R. L., and Wilhelm, Mable M.: Reticulocyte Counts in Healthy Children , Am. J. Clin. Path. 4:292 ( (May) ) 1934. 11. Osgood,4b p. 408. 12. The standard is obtainable from Hynson, Westcott and Dunning, Inc., Baltimore. 13. Dowden, C. W.; McNeill, C., and McNeill, J. D.: A Clinical Study of Blood Iron and Hemoglobin , J. Lab. & Clin. Med. 19:362 ( (Jan.) ) 1934. 14. The cell volume tube is obtainable from the Arthur H. Thomas Company, Philadelphia. 15. Wintrobe, M. M.: Size and Hemoglobin Content of the Erythrocyte , J. Lab. & Clin. Med. 17:899 ( (June) ) 1932. 16. Osgood,4b p. 411. 17. Arthur H. Thomas Company, catalog no. 3649-A. 18. The erythrocyte counts and determination of cell volume were made by Dr. Frank E. Trotman, Mr. Russell L. Baker and Mrs. Mable Wilhelm Osgood; the hemoglobin estimations and reticulocyte counts, by Mrs. Mable Wilhelm Osgood and me, and the leukocyte and differential counts and the determinations of the sedimentation rate, by Miss Inez Brownlee, Mr. Russell L. Baker and Mr. Howard Johnson. The calculations were all checked several times by Mrs. Mable Wilhelm Osgood, myself and others. 19. Williamson, C. S.: Influence of Age and Sex on Hemoglobin: A Spectrophotometric Study of Nine Hundred and Nineteen Cases , Arch. Int. Med. 18: 505 ( (Oct.) ) 1916. 20. Notwithstanding this fact, the Newcomer hemoglobinometer is standardized so that 100 per cent corresponds to the value of 16.92 Gm. per hundred cubic centimeters obtained by Williamson for men. 21. Haden, R. L.: Accurate Criteria for Differentiating Anemias , Arch. Int. Med. 31:766 ( (May) ) 1923. 22. Osgood, E. E.; Haskins, H. D., and Trotman, F. E.: The Value of Accurately Determined Color, Volume and Saturation Indexes in Anemias , J. Lab. & Clin. Med. 17:859 ( (June) ) 1932. 23. Osgood, E. E., and Haskins, H. D.: Causes, Classification and Differential Diagnosis of Anemias , Ann. Int. Med. 5:1367 ( (May) ) 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

NORMAL HEMATOLOGIC STANDARDS

Archives of Internal Medicine , Volume 56 (5) – Nov 1, 1935

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1935.00170030017002
Publisher site
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Abstract

Abstract This paper presents a summary of the results of a series of hematologic studies, including all the commonly used procedures, on over 500 healthy persons of both sexes ranging from young children to adults. Details of these studies1 together with reviews of the literature will appear elsewhere. The development of a uniform system of methods for the hematologic study of oxalated venous blood made this investigation possible. These methods are simple enough for routine clinical use, but they approach research methods in accuracy. Erythrocyte counts, hemoglobin values, hemoglobin coefficients and color indexes are reported for 626 persons; cell volumes, volume coefficients and volume and saturation indexes, for 583; reticulocyte counts, for 476; leukocyte and differential counts, for 597, and sedimentation rates, for 853. The ages of the subjects ranged from 4 years to past 30. SUBJECTS All the subjects lived in or near Portland, Ore., at an elevation of References 1. Mrs. Mable Wilhelm Osgood, Mr. Russell L. Baker and Miss Inez Brownlee collaborated in these studies. 2. Dr. Helen Cary and Dr. Frank Mount cooperated in securing suitable subjects from the schools and orphan asylums. 3. Many reports of so-called normal values have been based on studies of patients with minor illnesses in clinics or hospitals. This practice is to be condemned. It probably accounts for some of the differences between the standards determined by my associates and me and those in general use. 4. Osgood, E. E.; Haskins, H. D.; Trotman, F. E., and Mathieu, A.: A Uniform System of Hematologic Methods for Use with Oxalated Venous Blood: A Simplification of the Osgood-Haskins Hemoglobin Method; A Rapid Method for Determination of the Sedimentation Rate of the Red Cells with Results in Health and Disease , J. Lab. & Clin. Med. 16:476 ( (Feb.) ) 1931. 5. Osgood, E. E.: A Textbook of Laboratory Diagnosis , Philadelphia, P. Blakiston's Son & Co., ed. 2, 1935, pp. 192 and 378 6. Relation Between Cell Count, Cell Volume and Hemoglobin Content of Venous Blood of Normal Young Women , Arch. Int. Med. 39:643 ( (May) ) 1927. 7. Osgood, E. E.: Hemoglobin, Color Index, Saturation Index and Volume Index Standards , Arch. Int. Med. 37:685 ( (May) ) 1926 8. Tables for Calculation of Color Index, Volume Index and Saturation Index Based on Recently Determined Standards , J. Lab. & Clin. Med. 12:899 ( (June) ) 1927. 9. Osgood, E. E., and Wilhelm, Mable M.: Reticulocytes , J. Lab. & Clin. Med. 19:1129 ( (July) ) 1934. 10. Osgood, E. E.; Baker, R. L., and Wilhelm, Mable M.: Reticulocyte Counts in Healthy Children , Am. J. Clin. Path. 4:292 ( (May) ) 1934. 11. Osgood,4b p. 408. 12. The standard is obtainable from Hynson, Westcott and Dunning, Inc., Baltimore. 13. Dowden, C. W.; McNeill, C., and McNeill, J. D.: A Clinical Study of Blood Iron and Hemoglobin , J. Lab. & Clin. Med. 19:362 ( (Jan.) ) 1934. 14. The cell volume tube is obtainable from the Arthur H. Thomas Company, Philadelphia. 15. Wintrobe, M. M.: Size and Hemoglobin Content of the Erythrocyte , J. Lab. & Clin. Med. 17:899 ( (June) ) 1932. 16. Osgood,4b p. 411. 17. Arthur H. Thomas Company, catalog no. 3649-A. 18. The erythrocyte counts and determination of cell volume were made by Dr. Frank E. Trotman, Mr. Russell L. Baker and Mrs. Mable Wilhelm Osgood; the hemoglobin estimations and reticulocyte counts, by Mrs. Mable Wilhelm Osgood and me, and the leukocyte and differential counts and the determinations of the sedimentation rate, by Miss Inez Brownlee, Mr. Russell L. Baker and Mr. Howard Johnson. The calculations were all checked several times by Mrs. Mable Wilhelm Osgood, myself and others. 19. Williamson, C. S.: Influence of Age and Sex on Hemoglobin: A Spectrophotometric Study of Nine Hundred and Nineteen Cases , Arch. Int. Med. 18: 505 ( (Oct.) ) 1916. 20. Notwithstanding this fact, the Newcomer hemoglobinometer is standardized so that 100 per cent corresponds to the value of 16.92 Gm. per hundred cubic centimeters obtained by Williamson for men. 21. Haden, R. L.: Accurate Criteria for Differentiating Anemias , Arch. Int. Med. 31:766 ( (May) ) 1923. 22. Osgood, E. E.; Haskins, H. D., and Trotman, F. E.: The Value of Accurately Determined Color, Volume and Saturation Indexes in Anemias , J. Lab. & Clin. Med. 17:859 ( (June) ) 1932. 23. Osgood, E. E., and Haskins, H. D.: Causes, Classification and Differential Diagnosis of Anemias , Ann. Int. Med. 5:1367 ( (May) ) 1932.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Nov 1, 1935

References

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