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Nonobstructive Gastroparesis in Amyloidosis Improved With Metoclopramide

Nonobstructive Gastroparesis in Amyloidosis Improved With Metoclopramide Abstract • Patients with systemic amyloidosis often have symptoms related to impaired gastrointestinal motility. Delayed gastric emptying may result from autonomic nerve and/or smooth-muscle infiltration with amyloid. In two patients with gastro-paresis secondary to amyloidosis, metoclopramide hydrochloride therapy quantitatively enhanced gastric emptying. We suggest that metoclopramide treatment may be useful in the supportive therapy of patients with delayed gastric emptying due to amyloidosis. (Arch Intern Med 1983;143:247-248) References 1. Cohen AS: Amyloidosis. N Engl J Med 1967;277:522-583,628-637.Crossref 2. Kyle RA, Bayrd ED: Amyloidosis: Review of 236 cases. Medicine 1975;54:271-299.Crossref 3. Gilat T, Spiro HM: Amyloidosis and the gut. Am J Dig Dis 1968;13: 619-633.Crossref 4. Legge DA, Wollaeger EE, Carlson HC: Intestinal pseudo-obstruction in systemic amyloidosis. Gut 1970;11:764-767.Crossref 5. French JM, Hall G, Parish DL, et al: Peripheral and autonomic nerve involvement in primary amyloidosis associated with uncontrollable diarrhea and steatorrhea. Am J Med 1965;39:277-284.Crossref 6. Battle EM, Rubin MR, Cohen S, et al: Gastrointestinal motility dysfunction in amyloidosis. N Engl J Med 1979; 301:24-25.Crossref 7. Rubinow A, Harris LD, Cohen AS: Esophageal motor dysfunction in systemic amyloidosis , in Glenner GG, Costs PP, Freitas F (eds): Amyloid and Amyloidosis . Amsterdam, Excerpta Medica, 1980, pp 243-248. 8. De Jong R: The Neurological Examination , ed 4. Hagerstown, Md, Harper and Row Publishers Inc, 1980, pp 518-520. 9. Wright RA, Thompson D, Syed I: Simultaneous fluid and solid gastric emptying agents: New variations on an old theme. J Nucl Med 1981;22:772-776. 10. Wright RA, Krinsky S, Fleeman C, et al: Gastric emptying and obesity. Gastroenterology , in press. 11. Intriere AD, Brown CH: Primary amyloidosis: Report of a case of gastric involvement only. Gastroenterology 1956;30:833-838. 12. Schulze-Delrieu K: Metoclopramide. N Engl J Med 1981;305:28-33.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Nonobstructive Gastroparesis in Amyloidosis Improved With Metoclopramide

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350020069014
Publisher site
See Article on Publisher Site

Abstract

Abstract • Patients with systemic amyloidosis often have symptoms related to impaired gastrointestinal motility. Delayed gastric emptying may result from autonomic nerve and/or smooth-muscle infiltration with amyloid. In two patients with gastro-paresis secondary to amyloidosis, metoclopramide hydrochloride therapy quantitatively enhanced gastric emptying. We suggest that metoclopramide treatment may be useful in the supportive therapy of patients with delayed gastric emptying due to amyloidosis. (Arch Intern Med 1983;143:247-248) References 1. Cohen AS: Amyloidosis. N Engl J Med 1967;277:522-583,628-637.Crossref 2. Kyle RA, Bayrd ED: Amyloidosis: Review of 236 cases. Medicine 1975;54:271-299.Crossref 3. Gilat T, Spiro HM: Amyloidosis and the gut. Am J Dig Dis 1968;13: 619-633.Crossref 4. Legge DA, Wollaeger EE, Carlson HC: Intestinal pseudo-obstruction in systemic amyloidosis. Gut 1970;11:764-767.Crossref 5. French JM, Hall G, Parish DL, et al: Peripheral and autonomic nerve involvement in primary amyloidosis associated with uncontrollable diarrhea and steatorrhea. Am J Med 1965;39:277-284.Crossref 6. Battle EM, Rubin MR, Cohen S, et al: Gastrointestinal motility dysfunction in amyloidosis. N Engl J Med 1979; 301:24-25.Crossref 7. Rubinow A, Harris LD, Cohen AS: Esophageal motor dysfunction in systemic amyloidosis , in Glenner GG, Costs PP, Freitas F (eds): Amyloid and Amyloidosis . Amsterdam, Excerpta Medica, 1980, pp 243-248. 8. De Jong R: The Neurological Examination , ed 4. Hagerstown, Md, Harper and Row Publishers Inc, 1980, pp 518-520. 9. Wright RA, Thompson D, Syed I: Simultaneous fluid and solid gastric emptying agents: New variations on an old theme. J Nucl Med 1981;22:772-776. 10. Wright RA, Krinsky S, Fleeman C, et al: Gastric emptying and obesity. Gastroenterology , in press. 11. Intriere AD, Brown CH: Primary amyloidosis: Report of a case of gastric involvement only. Gastroenterology 1956;30:833-838. 12. Schulze-Delrieu K: Metoclopramide. N Engl J Med 1981;305:28-33.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1983

References