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Nonarteritic Anterior Ischemic Optic Neuropathy: Role of Nocturnal Arterial Hypotension-Reply

Nonarteritic Anterior Ischemic Optic Neuropathy: Role of Nocturnal Arterial Hypotension-Reply Abstract In reply We appreciate the opportunity to respond to the letter by Hayreh et al about our study of BP monitoring in patients with AION.1Because clinical hypotheses can best be tested by comparing patients and control subjects, we measured the 24-hour BP curves of patients with AION and matched controls. The BPs of patients with AION were neither hypertensive nor hypotensive. However, compared with matched controls, patients with AION had a lower mean systolic BP during the day. The most striking difference between the diurnal BP curves of patients with AION and the controls occurred in the morning after awakening, when patients with AION had a slower, more irregular increase in BP. We found the nocturnal nadir was no lower in patients with AION than in controls. Our study shows that patients with AION have a chronic tendency toward lower BP, predisposing them to hypoperfusion, perhaps because of References 1. Landau K, Winterkorn JMS, Mailloux LU, Vetter W, Napolitano B. 24-hour blood pressure monitoring in patients with anterior ischemic optic neuropathy . Arch Ophthalmol . 1996;114:570-575.Crossref 2. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WLM. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders . Am J Ophthalmol . 1994;117:603-624. 3. Ischemic Optic Neuropathy Decompression Trial Study Group. Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the Ischemic Optic Neuropathy Decompression Trial . Arch Ophthalmol . 1996;114:1366-1374.Crossref 4. Cohen J. Statistical Power Analysisfor the Behavioral Sciences . Orlando, Fla: Academic Press Inc; 1977. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Nonarteritic Anterior Ischemic Optic Neuropathy: Role of Nocturnal Arterial Hypotension-Reply

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1997.01100160112032
Publisher site
See Article on Publisher Site

Abstract

Abstract In reply We appreciate the opportunity to respond to the letter by Hayreh et al about our study of BP monitoring in patients with AION.1Because clinical hypotheses can best be tested by comparing patients and control subjects, we measured the 24-hour BP curves of patients with AION and matched controls. The BPs of patients with AION were neither hypertensive nor hypotensive. However, compared with matched controls, patients with AION had a lower mean systolic BP during the day. The most striking difference between the diurnal BP curves of patients with AION and the controls occurred in the morning after awakening, when patients with AION had a slower, more irregular increase in BP. We found the nocturnal nadir was no lower in patients with AION than in controls. Our study shows that patients with AION have a chronic tendency toward lower BP, predisposing them to hypoperfusion, perhaps because of References 1. Landau K, Winterkorn JMS, Mailloux LU, Vetter W, Napolitano B. 24-hour blood pressure monitoring in patients with anterior ischemic optic neuropathy . Arch Ophthalmol . 1996;114:570-575.Crossref 2. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WLM. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders . Am J Ophthalmol . 1994;117:603-624. 3. Ischemic Optic Neuropathy Decompression Trial Study Group. Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the Ischemic Optic Neuropathy Decompression Trial . Arch Ophthalmol . 1996;114:1366-1374.Crossref 4. Cohen J. Statistical Power Analysisfor the Behavioral Sciences . Orlando, Fla: Academic Press Inc; 1977.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1997

References