Abstract To the Editor. —In the March Archives, Armitage et al1 and Fisher2 reported on the increased frequency of non-Hodgkin's lymphomas in patients previously treated for Hodgkin's disease. Twenty-nine cases have been reported in the literature. The authors also pointed out the increased risk of nonlymphoblastic acute leukemia among these patients.Solid tumors can also occur after treatment for Hodgkin's disease. Different authors draw attention to this possibility.3-7 Two authors have specified whether or not the solid tumors occur within the irradiation field (IF).3,5 Arseneau et al3 described three solid tumors within the IF among 427 patients. All the patients were treated by radiotherapy and chemotherapy. Baccarani et al5 followed up 613 patients with Hodgkin's disease and five patients with solid tumors (one after chemotherapy alone, one after radiotherapy and chemotherapy far from the IF, and three after radiotherapy and chemotherapy within the IF).We References 1. Armitage JO, Dick FR, Goeken JA, et al: Second lymphoid malignant neoplasms occurring in patients treated for Hodgkin's disease. Arch Intern Med 1983;143:445-450.Crossref 2. Fisher RI: Non-Hodgkin's lymphomas after treatment of Hodgkin's disease. Arch Intern Med 1983;143:427.Crossref 3. Arseneau JC, Sponzo RW, Levin DL, et al: Non-lymphomatous malignant tumors complicating Hodgkin's disease. N Engl J Med 1972;287: 1119-1122.Crossref 4. Arseneau JC, Canellos GP, Johnson R, et al: Risk of new cancers in patients with Hodgkin's disease. Cancer 1977;40:1912-1916.Crossref 5. Baccarani M, Basi A, Papa G: Second malignancy in patients treated for Hodgkin's disease. Cancer 1980;46:1735-1740.Crossref 6. Brody RS, Schottenfeld D, Reid A: Multiple primary cancer risk after therapy for Hodgkin's disease. Cancer 1977;40:1917-1926.Crossref 7. Toland DM, Coltman CA Jr: Second malignancies complicating Hodgkin's disease. Blood 1975;46:1013.
Archives of Internal Medicine – American Medical Association
Published: May 1, 1984