Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Non-Hodgkin Lymphoma and Kaposi Sarcoma in an Eyelid of a Patient With Acquired Immunodeficiency Syndrome: Multiple Viruses in Pathogenesis

Non-Hodgkin Lymphoma and Kaposi Sarcoma in an Eyelid of a Patient With Acquired Immunodeficiency... Abstract A 36-year-old patient with the acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. This collision tumor is an unusual presentation of 2 malignant neoplasms in a patient with acquired immunodeficiency syndrome, with in situ hybridization evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in the lesion. References 1. Ziegler JL. Biologic differences in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphomas . J Clin Oncol . 1991;9:1329-1331. 2. Biggar RJ, Curtis RE, Cote TR, Rabkin CS, Melbyne M. Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome . Am J Epidemiol . 1994;139:362-368. 3. Herndier BG, Sanchez HC, Chang KL, Chen YY, Weiss LM. High prevalence of Epstein-Barrvirus in the Reed-Sternberg cells of HIV-associated Hodgkin's disease . Am J Pathol . 1993;142:1073-1079. 4. Staskus KA, Zhong W, Gebhard K, et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells . J Virol . 1997;71:715-719. 5. Robert C, Agbalika F, Blanc F, Dubertret L. HIV-negative patient with HHV-8 DNA folicular B-cell lymphoma associated with Kaposi's sarcoma . Lancet . 1996;347:1042-1043.Crossref 6. Ko AH, Thomas DL, Gallant JE. Non-Hodgkin's lymphoma and Kaposi's sarcoma causing cavitary lung lesions in a patient with AIDS: an HIV associated collision tumor . AIDS . 1995;9:1195-1197.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Non-Hodgkin Lymphoma and Kaposi Sarcoma in an Eyelid of a Patient With Acquired Immunodeficiency Syndrome: Multiple Viruses in Pathogenesis

Loading next page...
 
/lp/american-medical-association/non-hodgkin-lymphoma-and-kaposi-sarcoma-in-an-eyelid-of-a-patient-with-JnrUkytdf8
Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1997.01100160634020
Publisher site
See Article on Publisher Site

Abstract

Abstract A 36-year-old patient with the acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. This collision tumor is an unusual presentation of 2 malignant neoplasms in a patient with acquired immunodeficiency syndrome, with in situ hybridization evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in the lesion. References 1. Ziegler JL. Biologic differences in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphomas . J Clin Oncol . 1991;9:1329-1331. 2. Biggar RJ, Curtis RE, Cote TR, Rabkin CS, Melbyne M. Risk of other cancers following Kaposi's sarcoma: relation to acquired immunodeficiency syndrome . Am J Epidemiol . 1994;139:362-368. 3. Herndier BG, Sanchez HC, Chang KL, Chen YY, Weiss LM. High prevalence of Epstein-Barrvirus in the Reed-Sternberg cells of HIV-associated Hodgkin's disease . Am J Pathol . 1993;142:1073-1079. 4. Staskus KA, Zhong W, Gebhard K, et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells . J Virol . 1997;71:715-719. 5. Robert C, Agbalika F, Blanc F, Dubertret L. HIV-negative patient with HHV-8 DNA folicular B-cell lymphoma associated with Kaposi's sarcoma . Lancet . 1996;347:1042-1043.Crossref 6. Ko AH, Thomas DL, Gallant JE. Non-Hodgkin's lymphoma and Kaposi's sarcoma causing cavitary lung lesions in a patient with AIDS: an HIV associated collision tumor . AIDS . 1995;9:1195-1197.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1997

References