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ORIGINAL INVESTIGATION Non–High-Density Lipoprotein Cholesterol Level as a Predictor of Cardiovascular Disease Mortality Yadong Cui, MD, PhD; Roger S. Blumenthal, MD; Jodi A. Flaws, PhD; Maura K. Whiteman, BS; Patricia Langenberg, PhD; Paul S. Bachorik, PhD; Trudy L. Bush, PhD, MHS† Background: Non–high-density lipoprotein choles- Results: A total of 234 CVD deaths in men and 113 CVD terol (non–HDL-C) contains all known and potential ath- deaths in women occurred during follow-up. Levels of erogenic lipid particles. Therefore, non–HDL-C level may HDL-C and non–HDL-C at baseline were significant and be as good a potential predictor of risk for cardiovascu- strong predictors of CVD death in both sexes. In con- lar disease (CVD) as low-density lipoprotein choles- trast, LDL-C level was a somewhat weaker predictor of terol (LDL-C). CVD death in both. Differences of 0.78 mmol/L (30 mg/ dL) in non–HDL-C and LDL-C levels corresponded to Objectives: To determine whether non–HDL-C level could increases in CVD risk of 19% and 15%, respectively, in be useful in predicting CVD mortality and to compare the men. In women, differences of 0.78 mmol/L (30 mg/dL) predictive value of non–HDL-C and LDL-C levels. in non–HDL-C and LDL-C levels corresponded to in- creases in CVD risk
JAMA Internal Medicine – American Medical Association
Published: Jun 11, 2001
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