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Nodular Lesions on the Face and Trunk

Nodular Lesions on the Face and Trunk Abstract REPORT OF A CASE A 27-year-old man presented to the department of dermatology for evaluation and treatment of widespread nodular lesions on his face and trunk. He reported that the progressive development of the nodules began when he was 20 years old. The lesions were easily traumatized. He denied ocular symptoms, hoarseness, difficulty breathing, polydipsia, polyuria, or seizure disorder. No family history of a similar eruption could be elicited. He was otherwise healthy and took no medications.Findings from the physical examination revealed numerous nontender yellow-brown papules and nodules on his face, neck, and trunk, primarily in flexural areas, including the groin and axillae bilaterally (Figs 1 and 2). These lesions ranged from 1 to 3 cm.Laboratory data revealed normal serum lipid levels and normal results from urinalysis.A shave biopsy specimen of a nodule from the right antecubital fossa revealed a flattened epidermis surrounding a dermis heavily infiltrated References 1. Thannhauser SJ, Majendantz H. The different clinical groups of xanthomatous diseases . Ann Intern Med. 1938;2:1662-1746.Crossref 2. Turner XL. A case of xanthoma tuberosum with extensive distribution of xanthomatous nodules in the mucous membranes of the respiratory tract . J Laryngol. 1925;40:249-252.Crossref 3. Montgomery H, Osterberg, AE. Xanthomatous correlation of clinical, histopathologic and chemical studies of cutaneous xanthoma . Arch Derm Syphilol. 1938;37:373-402.Crossref 4. Altman J, Winkelman RK. Xanthoma disseminatum . Arch Dermatol. 1962;86:582-596.Crossref 5. Bromley GS, Gonlian D. Xanthomas disseminatum: an unusual cause of facial and limb deformity . Plast Reconstr Surg. 1983;72:552-556.Crossref 6. Kalz F, Hoffman MM, Lafrance A. Xanthoma disseminatum: clinical and laboratory observations over a 10 year period . Dermatologica. 1970;140:129-141.Crossref 7. Mishkel MA, Cockshott WP, Nazir DJ, et al. Xanthoma disseminatum: clinical, metabolic, pathologic, and radiologic aspects . Arch Dermatol. 1977;113:1094-1100.Crossref 8. Finney WP, Montgomery H, New GB. Xanthoma multiplex: two cases involving the larynx and trachea, and association with diabetes insipidus . JAMA. 1932; 99:1071.Crossref 9. Puig ML, Webb SM, Del Pozo C, et al. Endocrine aspects of pituitary stalk enlargement . Clin Endocrinol. 1987;27:25-32.Crossref 10. Blobstein SH, Caldwell D, Carter DM. Bone lesions in xanthoma disseminatum . Arch Dermatol. 1985;121:1313-1317.Crossref 11. Maize JC, Amhed R, Provost TT. Xanthoma disseminatum and multiple myeloma . Arch Dermatol. 1974;110:758-761.Crossref 12. Fleishmayer R. The Dyslipidoses . Springfield, Ill, Charles C Thomas Publisher; 1960:372-386. 13. Ringel E, Moschella S. Primary histiocytic dermatoses . Arch Dermatol. 1985;121:1531-1541.Crossref 14. Igisu K, Watanabe S. Immunohistochemical study of cutaneous histioproliferative lesions . Jpn J Clin Oncol. 1987;17:343-351. 15. Battaglini J, Olsen TG. Disseminated xanthosiderohistiocytosis, a variant of xanthoma disseminatum, in a patient with a plasma cell dyscrasia . J Am Acad Dermatol. 1984;11:750-755.Crossref 16. Gallant CJ, From L. Juvenile xanthogranulomas and xanthoma disseminatum: variations on a single theme . J Am Acad Dermatol. 1986;15:108-109.Crossref 17. Kumakiri M, Sudoh M, Miura Y. Xanthomas disseminatum, report of a case, with histological and ultrastructural studies of skin lesions . J Am Acad Dermatol. 1981;4:291-299.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Nodular Lesions on the Face and Trunk

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680100123020
Publisher site
See Article on Publisher Site

Abstract

Abstract REPORT OF A CASE A 27-year-old man presented to the department of dermatology for evaluation and treatment of widespread nodular lesions on his face and trunk. He reported that the progressive development of the nodules began when he was 20 years old. The lesions were easily traumatized. He denied ocular symptoms, hoarseness, difficulty breathing, polydipsia, polyuria, or seizure disorder. No family history of a similar eruption could be elicited. He was otherwise healthy and took no medications.Findings from the physical examination revealed numerous nontender yellow-brown papules and nodules on his face, neck, and trunk, primarily in flexural areas, including the groin and axillae bilaterally (Figs 1 and 2). These lesions ranged from 1 to 3 cm.Laboratory data revealed normal serum lipid levels and normal results from urinalysis.A shave biopsy specimen of a nodule from the right antecubital fossa revealed a flattened epidermis surrounding a dermis heavily infiltrated References 1. Thannhauser SJ, Majendantz H. The different clinical groups of xanthomatous diseases . Ann Intern Med. 1938;2:1662-1746.Crossref 2. Turner XL. A case of xanthoma tuberosum with extensive distribution of xanthomatous nodules in the mucous membranes of the respiratory tract . J Laryngol. 1925;40:249-252.Crossref 3. Montgomery H, Osterberg, AE. Xanthomatous correlation of clinical, histopathologic and chemical studies of cutaneous xanthoma . Arch Derm Syphilol. 1938;37:373-402.Crossref 4. Altman J, Winkelman RK. Xanthoma disseminatum . Arch Dermatol. 1962;86:582-596.Crossref 5. Bromley GS, Gonlian D. Xanthomas disseminatum: an unusual cause of facial and limb deformity . Plast Reconstr Surg. 1983;72:552-556.Crossref 6. Kalz F, Hoffman MM, Lafrance A. Xanthoma disseminatum: clinical and laboratory observations over a 10 year period . Dermatologica. 1970;140:129-141.Crossref 7. Mishkel MA, Cockshott WP, Nazir DJ, et al. Xanthoma disseminatum: clinical, metabolic, pathologic, and radiologic aspects . Arch Dermatol. 1977;113:1094-1100.Crossref 8. Finney WP, Montgomery H, New GB. Xanthoma multiplex: two cases involving the larynx and trachea, and association with diabetes insipidus . JAMA. 1932; 99:1071.Crossref 9. Puig ML, Webb SM, Del Pozo C, et al. Endocrine aspects of pituitary stalk enlargement . Clin Endocrinol. 1987;27:25-32.Crossref 10. Blobstein SH, Caldwell D, Carter DM. Bone lesions in xanthoma disseminatum . Arch Dermatol. 1985;121:1313-1317.Crossref 11. Maize JC, Amhed R, Provost TT. Xanthoma disseminatum and multiple myeloma . Arch Dermatol. 1974;110:758-761.Crossref 12. Fleishmayer R. The Dyslipidoses . Springfield, Ill, Charles C Thomas Publisher; 1960:372-386. 13. Ringel E, Moschella S. Primary histiocytic dermatoses . Arch Dermatol. 1985;121:1531-1541.Crossref 14. Igisu K, Watanabe S. Immunohistochemical study of cutaneous histioproliferative lesions . Jpn J Clin Oncol. 1987;17:343-351. 15. Battaglini J, Olsen TG. Disseminated xanthosiderohistiocytosis, a variant of xanthoma disseminatum, in a patient with a plasma cell dyscrasia . J Am Acad Dermatol. 1984;11:750-755.Crossref 16. Gallant CJ, From L. Juvenile xanthogranulomas and xanthoma disseminatum: variations on a single theme . J Am Acad Dermatol. 1986;15:108-109.Crossref 17. Kumakiri M, Sudoh M, Miura Y. Xanthomas disseminatum, report of a case, with histological and ultrastructural studies of skin lesions . J Am Acad Dermatol. 1981;4:291-299.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1991

References