Abstract • The involvement of human T-cell leukemia viruses (HTLVs) in the pathogenesis of 18 Hungarian patients with multiple sclerosis was investigated. No antibody to HTLVs could be detected in any of the patients. Furthermore, using polymerase chain reaction under highly sensitive conditions, neither HTLV-I DNA nor HTLV-II DNA could be noted in peripheral blood lymphocytes of the patients. Our data do not support a causal association of HTLV-I or HTLV-II with multiple sclerosis. References 1. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma . Proc Natl Acad Sci U S A . 1980;77:7415-7419.Crossref 2. Chen ISY, McLaughlin J, Gasson JC, Clark SC, Golde DW. Molecular characterization of genome of a novel T-cell leukemia virus . Nature . 1983;305:502-505.Crossref 3. Rosenblatt JD, Golde DW, Wachsman W, et al. A second isolate of HTLV-II associated with atypical hairy cell leukemia . N Engl J Med . 1986;315:372-375.Crossref 4. Gessain A, Vernant JC, Maurs L, et al. Antibodies to human T-lymphotropic virus type-1 in patients with tropical spastic paraparesis . Lancet . 1985;2:407-410.Crossref 5. Jacobson S, Raine CS, Mingioli ES, McFarlin DE. Isolation of an HTLV-I-like retrovirus from patients with tropical spastic paraparesis . Nature . 1988;331:540-543.Crossref 6. Koprowski H, DeFreitas EC, Harper ME, et al. Multiple sclerosis and human T-cell lymphotropic retroviruses . Nature . 1985;318:154-160.Crossref 7. Hauser SL, Aubert C, Burks JS, et al. Analysis of human T-lymphotropic virus sequences in multiple sclerosis tissue . Nature . 1986;322:176-177.Crossref 8. Karpas A, Kampf U, Siden A, Koch M, Poser S. Lack of evidence for involvement of known human retroviruses in multiple sclerosis . Nature . 1986;322:177-178.Crossref 9. Reddy EP, Sandberg-Wollheim M, Mettus RV, Ray PF, Defreitas E, Koprowski H. Amplification and molecular cloning of HTLV-I sequences from DNA of multiple sclerosis patients . Science . 1989;243:529-533.Crossref 10. Greenberg SJ, Ehrlich GD, Abbott MA, Hurwitz BJ, Waldmann TA, Poiesz BJ. Detection of sequences homologous to human retroviral DNA in multiple sclerosis by gene amplification . Proc Natl Acad Sci USA . 1989;86:2878-2882.Crossref 11. Bangham CRM, Nightingale S, Cruickshank JK, Daenke S. PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I . Science . 1989;246:821. 12. Richardson JH, Wucherpfennig KW, Endo N, Rudge P, Dalgleish AG, Hafler DA. PCR analysis of DNA from multiple sclerosis patients for the presence of HTLV-I . Science . 1989;246:821-824.Crossref 13. Paterson PY, Swanborg RH. Demyelinating diseases of the central and peripheral nervous system . In: Samter M, Talmage DW, Frank MM, Austen KF, Claman HN, eds. Immunological Diseases . Boston, Mass: Little Brown & Co; 1988:1877-1961. 14. Nagy K, Gyuris A, Drexler E, Foldes I, Fust G, Horvath A. Human T-lymphotrophic virus infections in Hungary . In: Lapis K, Eckhardt S, eds. Molecular Biology and Differentiation of Cancer Cells . Basel, Switzerland: S Karger AG; 1987:283-290. 15. Maeda Y, Furakawa M, Takehara Y, et al. Prevalence of possible adult T-cell leukemia virus-carriers among volunteer blood donors in Japan: a nationwide study . Int J Cancer . 1984;33:717-730.Crossref 16. Lee H, Swanson P, Shorty VS, Zack JA, Rosenblatt JD, Chen ISY. High rate of HTLV-II infection in seropositive IV drug abusers in New Orleans . Science . 1989;244:471-475.Crossref 17. Poser CM, Paty D, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols . Ann Neurol . 1983;13:227-231.Crossref 18. Mullis KB, Faloona FA. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction . Methods Enzymol . 1987;155:335-350. 19. Kitchin PA, Szotyori Z, Fromholc C, Almond N. Avoidance of false positives . Nature . 1990;344:201.Crossref 20. Mager DL, Freeman JD. Human endogenous retroviruslike genome with type C pol sequences and gag sequences related to human T-cell lymphotropic viruses . J Virol . 1987;61:4060-4066. 21. Perl A, Rosenblatt JD, Chen ISY, et al. Detection and cloning of new HTLV-related sequences in man . Nucleic Acids Res . 1989;17:6841-6854.Crossref 22. Perl A, Wang N, Williams JM, et al. Aberrant immunoglobulin and c-myc gene rearrangements in patients with nonmalignant monoclonal cryoglobulinemia . J Immunol . 1987;139:3512-3520. 23. Seiki M, Hattori S, Hirayama Y, Yoshida M. Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA . Proc Natl Acad Sci USA . 1983;80:3618-3622.Crossref 24. Shimotono K, Takahashi Y, Shimizu N, et al. Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene . Proc Natl Acad Sci USA . 1985;82:3101-3105.Crossref
Archives of Neurology – American Medical Association
Published: Oct 1, 1990
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