Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

NITRITOID REACTION TO TRYPARSAMIDE: REPORT OF A CASE

NITRITOID REACTION TO TRYPARSAMIDE: REPORT OF A CASE Abstract Vasomotor reactions not uncommonly occur to the arsenicals used in the treatment of syphilis, especially to the trivalent arsphenamines. The pentavalent tryparsamide, however, rarely produces ill effects. Moore1 stated that "visual damage is the only complication of tryparsamide therapy to be feared." With 6,933 injections of tryparsamide given by the medical department of the United States Navy,2 only 1 untoward result occurred: a mild exfoliative dermatitis. A thorough search of the literature revealed a paucity of reports of vasomotor reactions to this drug. A suggestive report was that of Miller and O'Donnell,3 whose patient suffered a profound collapse with generalized pallor of the skin, rather than the rubor associated with the so-called nitritoid reaction. Recently, however, Astrachan and Franks4 reported a typical nitritoid reaction in a 32 year old woman and also referred to two previous reports.5 According to Stokes6 and O'Leary,7 this References 1. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933. 2. Phelps, J. R., and Washburn, W. A.: Toxic Effects of Arsenical Compounds Employed in the Treatment of Syphilis in the United States Navy , Urol. & Cutan. Rev. 34:458 ( (July) ) 1930. 3. Miller, J. K., and O'Donnell, H. J.: Sensitivity to Tryparsamide , Arch. Dermat. & Syph. 35:264 ( (Feb.) ) 1937. 4. Astrachan, G. D., and Franks, A. G.: Nitritoid Reaction Following an Injection of Tryparsamide , Arch. Dermat. & Syph. 38:949 ( (Dec.) ) 1938. 5. O'Leary, P., and Becker, S.: Further Observations on the Treatment of Neurosyphilis with Tryparsamide , M. J. & Rec. 123:305 ( (March 3) ) 1926. 6. Silverston, J. D.: Observations on Tryparsamide Therapy in Neurosyphilis , Lancet 2:693 ( (Oct. 2) ) 1926. 7. Stokes, J. H.: Personal communication to the author, February 1938. 8. O'Leary, P. A.: Personal communication to the author, February 1938. 9. Mayer, L. L.: Tryparsamide Therapy of Neurosyphilis and Atrophy of the Optic Nerve , J. A. M. A. 109:1793 ( (Nov. 27) ) 1937. 10. Bragman, L. J.: Tryparsamide Dermatitis: Report of a Case and Survey of Literature , Am. J. Syph. & Neurol. 18:308 ( (July) ) 1934. 11. Hoverson, E. T.: Psychosis Associated with the Administration of Tryparsamide , Am. J. Syph. & Neurol. 19:217 ( (April) ) 1935. 12. Rosenberg, W. A.: Bilateral Asymmetrical Herpes Zoster (Following Tryparsamide Therapy) , Illinois M. J. 74:164 ( (Aug.) ) 1938. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

NITRITOID REACTION TO TRYPARSAMIDE: REPORT OF A CASE

Loading next page...
 
/lp/american-medical-association/nitritoid-reaction-to-tryparsamide-report-of-a-case-IRkzd3zcbK
Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1940.01490100054009
Publisher site
See Article on Publisher Site

Abstract

Abstract Vasomotor reactions not uncommonly occur to the arsenicals used in the treatment of syphilis, especially to the trivalent arsphenamines. The pentavalent tryparsamide, however, rarely produces ill effects. Moore1 stated that "visual damage is the only complication of tryparsamide therapy to be feared." With 6,933 injections of tryparsamide given by the medical department of the United States Navy,2 only 1 untoward result occurred: a mild exfoliative dermatitis. A thorough search of the literature revealed a paucity of reports of vasomotor reactions to this drug. A suggestive report was that of Miller and O'Donnell,3 whose patient suffered a profound collapse with generalized pallor of the skin, rather than the rubor associated with the so-called nitritoid reaction. Recently, however, Astrachan and Franks4 reported a typical nitritoid reaction in a 32 year old woman and also referred to two previous reports.5 According to Stokes6 and O'Leary,7 this References 1. Moore, J. E.: The Modern Treatment of Syphilis , Springfield, Ill., Charles C. Thomas, Publisher, 1933. 2. Phelps, J. R., and Washburn, W. A.: Toxic Effects of Arsenical Compounds Employed in the Treatment of Syphilis in the United States Navy , Urol. & Cutan. Rev. 34:458 ( (July) ) 1930. 3. Miller, J. K., and O'Donnell, H. J.: Sensitivity to Tryparsamide , Arch. Dermat. & Syph. 35:264 ( (Feb.) ) 1937. 4. Astrachan, G. D., and Franks, A. G.: Nitritoid Reaction Following an Injection of Tryparsamide , Arch. Dermat. & Syph. 38:949 ( (Dec.) ) 1938. 5. O'Leary, P., and Becker, S.: Further Observations on the Treatment of Neurosyphilis with Tryparsamide , M. J. & Rec. 123:305 ( (March 3) ) 1926. 6. Silverston, J. D.: Observations on Tryparsamide Therapy in Neurosyphilis , Lancet 2:693 ( (Oct. 2) ) 1926. 7. Stokes, J. H.: Personal communication to the author, February 1938. 8. O'Leary, P. A.: Personal communication to the author, February 1938. 9. Mayer, L. L.: Tryparsamide Therapy of Neurosyphilis and Atrophy of the Optic Nerve , J. A. M. A. 109:1793 ( (Nov. 27) ) 1937. 10. Bragman, L. J.: Tryparsamide Dermatitis: Report of a Case and Survey of Literature , Am. J. Syph. & Neurol. 18:308 ( (July) ) 1934. 11. Hoverson, E. T.: Psychosis Associated with the Administration of Tryparsamide , Am. J. Syph. & Neurol. 19:217 ( (April) ) 1935. 12. Rosenberg, W. A.: Bilateral Asymmetrical Herpes Zoster (Following Tryparsamide Therapy) , Illinois M. J. 74:164 ( (Aug.) ) 1938.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Apr 1, 1940

References