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Nitrazepam in Myoclonic Epilepsies

Nitrazepam in Myoclonic Epilepsies Abstract MYOCLONIC seizures of infancy and early childhood are generally resistant to conventional anticonvulsant drugs although their treatment has been facilitated in part by the use of corticotropin.1,2 Corticotropin is advocated particularly in young infants with hypsarhythmia in the electroencephalogram; a beneficial response is unrelated to the apparent cause of the seizures.2 Partial and occasionally complete control of seizures may be expected in approximately 50% of patients with infantile spasms but the remainder are unresponsive and mental deterioration is unrelieved. The need for new and more effective agents in the management of this type of seizure disorder is apparent. Nitrazepam (Mogadon), an analogue of chlordiazepoxide hydrochloride (Librium), is more potent than other benzodiazepine derivatives against experimental seizures in animals; its anticonvulsant efficacy has been demonstrated in clinical trials. Liske and Forster3 found that myoclonic, psychomotor, and petit mal seizure patterns were influenced most favorably. Markham4 recommended nitrazepam References 1. Stamps, F.W.; Gibbs, E.L.; and Rosenthal, I.M.: Treatment of Hypsarhythmia With ACTH , JAMA 171:408-411 ( (Sept 26) ) 1959.Crossref 2. Millichap, J.G., and Bickford, R.G.: Infantile Spasms, Hypsarhythmia and Mental Retardation , JAMA 182:523-527 ( (Nov 3) ) 1962.Crossref 3. Liske, E., and Forster, F.M.: Clinical Study of a New Benzodiazepine as an Anticonvulsant Agent , J New Drugs 3:241-244 ( (July) -Aug) 1963.Crossref 4. Markham, C.H.: Treatment of Myoclonic Seizures of Infancy and Childhood With LA-1 , Pediatrics 34:511-518 ( (Oct) ) 1964. 5. Gibbs, F.A., and Anderson, E.M.: Treatment of Hypsarhythmia and Infantile Spasms With a Librium Analogue , Neurology 15:1173-1176 ( (Dec) ) 1965.Crossref 6. Kaim, S.C., and Rosenstein, I.N.: Experience With Chlordiazepoxide in the Management of Epilepsy , J Neuropsychiat 3:12-17 ( (Oct) ) 1961. 7. Soriano, V.: Librium en la Epilepsia , Psychopharmacol Abstr 1:503 ( (Oct) ) 1961. 8. Bercel, N.: Chlordiazepoxide (Librium) as an Anticonvulsant , Dis Nerv Syst 22 ( (suppl) ):17-19 (July) 1961. 9. Merlis, S.; Turner, W.J.; and Halpern, S.: Chlordiazepoxide as Adjunctive Therapy in Con- vulsive Disorders , Amer J Psychiat 119:575-576 ( (Dec) ) 1962. 10. Barsa, J.A., and Saunders, J.C.: Chlordiazepoxide in the Treatment of Psychotics With Convulsive Disorders , Dis Nerv Syst 23:1-3 ( (Feb) ) 1962. 11. Brodie, R.E., and Dow, R.S.: Chlordiazepoxide in Epilepsy , Northwest Med 61:513-516 ( (June) ) 1962. 12. Masciocchi, A.: Metaminodiazepoxide (Librium) in the Treatment of Epilepsy (Clinical and Electroencephalographic Study) , abstracted, Electroenceph Clin Neurophysiol 15:919 ( (Oct) ) 1963. 13. Livingston, S.; Pauli, L.; and Murphy, J.B.: Ineffectiveness of Chlordiazepoxide Hydrochloride in Epilepsy , JAMA 177:243-244 ( (July) 29) 1961.Crossref 14. Weinberg, W.A., and Harwell, J.L.: Diazepam (Valium) in Myoclonic Seizures , Amer J Dis Child 109:123-127 ( (Feb) ) 1965.Crossref 15. Poiré, R.; Degraeve, M.; and Beck, L.: Etude électrographique comparative de l'action inhibitrice de certaines drogues sur les photo-myoclonies de l'homme , Rev Neurol 110:270-290, 1964. 16. Gastaut, H., et al: Treatment of Status Epilepticus With Diazepam (Valium) , Epilepsia 6:167-182, 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Nitrazepam in Myoclonic Epilepsies

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1966.02090120110012
Publisher site
See Article on Publisher Site

Abstract

Abstract MYOCLONIC seizures of infancy and early childhood are generally resistant to conventional anticonvulsant drugs although their treatment has been facilitated in part by the use of corticotropin.1,2 Corticotropin is advocated particularly in young infants with hypsarhythmia in the electroencephalogram; a beneficial response is unrelated to the apparent cause of the seizures.2 Partial and occasionally complete control of seizures may be expected in approximately 50% of patients with infantile spasms but the remainder are unresponsive and mental deterioration is unrelieved. The need for new and more effective agents in the management of this type of seizure disorder is apparent. Nitrazepam (Mogadon), an analogue of chlordiazepoxide hydrochloride (Librium), is more potent than other benzodiazepine derivatives against experimental seizures in animals; its anticonvulsant efficacy has been demonstrated in clinical trials. Liske and Forster3 found that myoclonic, psychomotor, and petit mal seizure patterns were influenced most favorably. Markham4 recommended nitrazepam References 1. Stamps, F.W.; Gibbs, E.L.; and Rosenthal, I.M.: Treatment of Hypsarhythmia With ACTH , JAMA 171:408-411 ( (Sept 26) ) 1959.Crossref 2. Millichap, J.G., and Bickford, R.G.: Infantile Spasms, Hypsarhythmia and Mental Retardation , JAMA 182:523-527 ( (Nov 3) ) 1962.Crossref 3. Liske, E., and Forster, F.M.: Clinical Study of a New Benzodiazepine as an Anticonvulsant Agent , J New Drugs 3:241-244 ( (July) -Aug) 1963.Crossref 4. Markham, C.H.: Treatment of Myoclonic Seizures of Infancy and Childhood With LA-1 , Pediatrics 34:511-518 ( (Oct) ) 1964. 5. Gibbs, F.A., and Anderson, E.M.: Treatment of Hypsarhythmia and Infantile Spasms With a Librium Analogue , Neurology 15:1173-1176 ( (Dec) ) 1965.Crossref 6. Kaim, S.C., and Rosenstein, I.N.: Experience With Chlordiazepoxide in the Management of Epilepsy , J Neuropsychiat 3:12-17 ( (Oct) ) 1961. 7. Soriano, V.: Librium en la Epilepsia , Psychopharmacol Abstr 1:503 ( (Oct) ) 1961. 8. Bercel, N.: Chlordiazepoxide (Librium) as an Anticonvulsant , Dis Nerv Syst 22 ( (suppl) ):17-19 (July) 1961. 9. Merlis, S.; Turner, W.J.; and Halpern, S.: Chlordiazepoxide as Adjunctive Therapy in Con- vulsive Disorders , Amer J Psychiat 119:575-576 ( (Dec) ) 1962. 10. Barsa, J.A., and Saunders, J.C.: Chlordiazepoxide in the Treatment of Psychotics With Convulsive Disorders , Dis Nerv Syst 23:1-3 ( (Feb) ) 1962. 11. Brodie, R.E., and Dow, R.S.: Chlordiazepoxide in Epilepsy , Northwest Med 61:513-516 ( (June) ) 1962. 12. Masciocchi, A.: Metaminodiazepoxide (Librium) in the Treatment of Epilepsy (Clinical and Electroencephalographic Study) , abstracted, Electroenceph Clin Neurophysiol 15:919 ( (Oct) ) 1963. 13. Livingston, S.; Pauli, L.; and Murphy, J.B.: Ineffectiveness of Chlordiazepoxide Hydrochloride in Epilepsy , JAMA 177:243-244 ( (July) 29) 1961.Crossref 14. Weinberg, W.A., and Harwell, J.L.: Diazepam (Valium) in Myoclonic Seizures , Amer J Dis Child 109:123-127 ( (Feb) ) 1965.Crossref 15. Poiré, R.; Degraeve, M.; and Beck, L.: Etude électrographique comparative de l'action inhibitrice de certaines drogues sur les photo-myoclonies de l'homme , Rev Neurol 110:270-290, 1964. 16. Gastaut, H., et al: Treatment of Status Epilepticus With Diazepam (Valium) , Epilepsia 6:167-182, 1965.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Sep 1, 1966

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