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News & Analysis Biotech Innovations Next-Generation Monoclonal Antibody through mosquito saliva. This effectively izing titers the most. Although the approach Blocks Malaria in Early Trial halts the infection by keeping the sporozo- also increased vaccine-related adverse An investigational monoclonal antibody ites from attaching to liver cells, preventing events, none were serious. calledL9LSprotectedmostrecipientsagainst production of the merozoites that then in- The study enrolled 1314 individuals in malaria after controlled infection in a small fectandmassivelymultiplyinredbloodcells. Argentina divided into 3 groups to receive phase 1 clinical trial, according to a report in L9LS also promotes the cytolytic destruc- their first vaccine dose: 669 received the New England Journal of Medicine. tion of sporozoites. Sputnik V C1 (Gamaleya Institute), a non- Currently, no antimalarial antibody is “Thecurrenttrialprovidesaproofofprin- replicating adenovirus vaccine; 448 approved for clinical use. If successfully ciple that prevention of malaria can be received ChAdOx1-S (Oxford-AstraZeneca), developed, adding antibodies to chemo- achieved with a next-generation monoclo- also an adenovirus vaccine; and 197 prevention and vaccine therapies might nal antibody, L9LS,” the authors wrote. The received BBIBP-CorV (Sinopharm), an inac- substantially reduce malaria-related illness authors reported that 2 phase 2 clinical trials tivated virus vaccine. The 3 first-dose and deaths. The subcutaneous injection,
JAMA – American Medical Association
Published: Sep 13, 2022
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