Abstract IN THIS paper a clinically useful method for dissolving calcific corneal opacities by means of a solution of the neutral sodium salt of ethylenediamine tetraacetic acid is reported. Treatment with a solution of this material is appropriate for corneal opacities which consist of calcific deposits in the anterior layers of the stroma or in the epithelium. This type of corneal opacity may be exogenous, resulting from a lime burn, or may be endogenous in the band keratopathies associated with protracted uveitis, hypercalcemia, or phthisis bulbi. No effect from treatment with this solution is to be expected in opacities which are noncalcific, such as result from edema, infiltration with inflammatory cells, scarring, or vascularization.1 The purpose of treatment for removal of calcific corneal opacities may be to improve vision when the opacities are axially situated or to relieve discomfort when calcific particles are being spontaneously extruded through the corneal epithelium. References 1. Some clearing effect would be expected in corneal opacities due to other metallic elements, e. g., barium and lead; but no actual investigation of these has yet been made. Initial trials on corneal rust rings from steel or iron foreign bodies have been disappointing. 2. These commercial preparations are much more concentrated and much more alkaline than the solution to be recommended for treatment of the cornea. 3. This solution may be prepared from analytical-grade disodium ethylenediamine tetraacetate dihydrate (also called "disodium versenate"), obtainable from the Bersworth Chemical Co., Framingham, Mass. The solution is prepared by dissolving 0.37 gm. of this compound in 100 ml. of distilled water and adding 0.10 gm. of sodium bicarbonate. Sterilization is accomplished by autoclaving or boiling. 4. Grant, W. M.: Chemical Burns of the Eye: Emergency Treatment , M. Clin. North America 36:1215, 1952.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Dec 1, 1952
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera