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NEW ANTIBACTERIAL DETERGENT FOR COMMON SKIN DISEASES IN CHILDREN: Use in Prophylaxis and Treatment

NEW ANTIBACTERIAL DETERGENT FOR COMMON SKIN DISEASES IN CHILDREN: Use in Prophylaxis and Treatment Abstract In the summer of 1951, while we were on pediatric service at an affiliate children's hospital and infant home, we were impressed with the prevalence of skin disorders, such as urticaria, impetigo, diaper rash, secondary infection occurring after insect bites, and heat rash among children. It seemed that an agent which would reduced the incidence of these conditions and yet not sensitize or irritate the skin might be of value. A new antibacterial detergent1 was considered to be worthy of clinical investigation. Interest was aroused in this product because of its reported cleansing and antibacterial properties2 and because of the published reports of the antibacterial properties of pHisoHex (Winthrop-Stearns),3 a similar antibacterial synthetic detergent containing 3% of hexachlorophene on a total weight basis, used as surgical "prep" by surgeons and nurses. PURPOSE The purpose of this study was to determine whether a soapless antibacterial cleansing agent References 1. The detergent used in the study was Tod'l, manufactured and supplied by the Centaur-Caldwell Division of Sterling Drugs, Inc. This product is an emulsion composed of a sulfonated ether, petrolatum, and wool fat cholesterols. It contains hexachlorophene, 0.5%, which is a bactericidal synthetic diphenol with the chemical formula bis-(2-hydroxy-3,5,6-trichlorophenyl) methane. 2. Dennis, E. W.: Unpublished data in the files of Sterling-Winthrop Research Institute. 3. Walter, C. W.: The Aseptic Treatment of Wounds , New York, The Macmillan Company, 1948. 4. Fine, J.: The Care of the Surgical Patient , Philadelphia, W. B. Saunders Company, 1949. 5. Thirlby, R. L., and Nesbit, R. M.: Clinical Evaluation of a Bactericidal Detergent for Hand Preparation in Urologic Practice , J. Urol. 62:617 ( (Oct.) ) 1949. 6. Bowers, R. F.: pHisoderm with Hexachlorophene (G-11): Its Integrity as a Surgical Scrub , Am. J. Surg. 78:859 ( (Dec.) ) 1949.Crossref 7. Chisholm, T. C.; Duncan, T. L.; Hufnagel, C. A., and Walter, C. W.: Disinfecting Action of pHisoderm Containing 3 Per Cent Hexachlorophene on the Skin of the Hands , Surgery 28:812 ( (Nov) ) 1950. 8. Freeman, B. S., and Young, T. K., Jr.: Use of a Detergent (pHisoderm®) Combined with Hexachlorophene for Skin Disinfection , Arch. Surg. 61: 1145 ( (Dec.) ) 1950.Crossref 9. Artz, C. P.; Pulaski, E. J., and Shaeffer, J. R.: Clinical Uses of Hexachlorophene , U. S. Armed Forces M. J. 2:819 ( (May) ) 1951. 10. Dull, J. A.; Zintel, H. A.; Ellis, H. L., and Nichols, A.: An Evaluation of pHisoderm G-11 and a Liquid Soap Containing G-11 When Used as the Preoperative Scrub , Surg, Gynec. & Obst. 91:100 ( (July) ) 1950. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

NEW ANTIBACTERIAL DETERGENT FOR COMMON SKIN DISEASES IN CHILDREN: Use in Prophylaxis and Treatment

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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1953.01540070086013
Publisher site
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Abstract

Abstract In the summer of 1951, while we were on pediatric service at an affiliate children's hospital and infant home, we were impressed with the prevalence of skin disorders, such as urticaria, impetigo, diaper rash, secondary infection occurring after insect bites, and heat rash among children. It seemed that an agent which would reduced the incidence of these conditions and yet not sensitize or irritate the skin might be of value. A new antibacterial detergent1 was considered to be worthy of clinical investigation. Interest was aroused in this product because of its reported cleansing and antibacterial properties2 and because of the published reports of the antibacterial properties of pHisoHex (Winthrop-Stearns),3 a similar antibacterial synthetic detergent containing 3% of hexachlorophene on a total weight basis, used as surgical "prep" by surgeons and nurses. PURPOSE The purpose of this study was to determine whether a soapless antibacterial cleansing agent References 1. The detergent used in the study was Tod'l, manufactured and supplied by the Centaur-Caldwell Division of Sterling Drugs, Inc. This product is an emulsion composed of a sulfonated ether, petrolatum, and wool fat cholesterols. It contains hexachlorophene, 0.5%, which is a bactericidal synthetic diphenol with the chemical formula bis-(2-hydroxy-3,5,6-trichlorophenyl) methane. 2. Dennis, E. W.: Unpublished data in the files of Sterling-Winthrop Research Institute. 3. Walter, C. W.: The Aseptic Treatment of Wounds , New York, The Macmillan Company, 1948. 4. Fine, J.: The Care of the Surgical Patient , Philadelphia, W. B. Saunders Company, 1949. 5. Thirlby, R. L., and Nesbit, R. M.: Clinical Evaluation of a Bactericidal Detergent for Hand Preparation in Urologic Practice , J. Urol. 62:617 ( (Oct.) ) 1949. 6. Bowers, R. F.: pHisoderm with Hexachlorophene (G-11): Its Integrity as a Surgical Scrub , Am. J. Surg. 78:859 ( (Dec.) ) 1949.Crossref 7. Chisholm, T. C.; Duncan, T. L.; Hufnagel, C. A., and Walter, C. W.: Disinfecting Action of pHisoderm Containing 3 Per Cent Hexachlorophene on the Skin of the Hands , Surgery 28:812 ( (Nov) ) 1950. 8. Freeman, B. S., and Young, T. K., Jr.: Use of a Detergent (pHisoderm®) Combined with Hexachlorophene for Skin Disinfection , Arch. Surg. 61: 1145 ( (Dec.) ) 1950.Crossref 9. Artz, C. P.; Pulaski, E. J., and Shaeffer, J. R.: Clinical Uses of Hexachlorophene , U. S. Armed Forces M. J. 2:819 ( (May) ) 1951. 10. Dull, J. A.; Zintel, H. A.; Ellis, H. L., and Nichols, A.: An Evaluation of pHisoderm G-11 and a Liquid Soap Containing G-11 When Used as the Preoperative Scrub , Surg, Gynec. & Obst. 91:100 ( (July) ) 1950.

Journal

A.M.A. Archives of Dermatology & Syphilology – American Medical Association

Published: Jul 1, 1953

References

  • The Aseptic Treatment of Wounds
    Walter , C. W.
  • The Care of the Surgical Patient
    Fine , J.
  • Clinical Evaluation of a Bactericidal Detergent for Hand Preparation in Urologic Practice
    Thirlby , R. L., and Nesbit, R. M.
  • pHisoderm with Hexachlorophene (G-11): Its Integrity as a Surgical Scrub
    Bowers , R. F.
  • Disinfecting Action of pHisoderm Containing 3 Per Cent Hexachlorophene on the Skin of the Hands
    Chisholm , T. C.; Duncan, T. L.; Hufnagel, C. A., and Walter, C. W.
  • Use of a Detergent (pHisoderm®) Combined with Hexachlorophene for Skin Disinfection
    Freeman , B. S., and Young, T. K., Jr.
  • Clinical Uses of Hexachlorophene
    Artz , C. P.; Pulaski, E. J., and Shaeffer, J. R.
  • An Evaluation of pHisoderm G-11 and a Liquid Soap Containing G-11 When Used as the Preoperative Scrub
    Dull , J. A.; Zintel, H. A.; Ellis, H. L., and Nichols, A.