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NEUROTOXIC SYMPTOMS FOLLOWING INGESTION OF ASTEROL DIHYDROCHLORIDE

NEUROTOXIC SYMPTOMS FOLLOWING INGESTION OF ASTEROL DIHYDROCHLORIDE THROUGH communication with Hoffmann-LaRoche, Inc., manufacturers of the antifungal drug Asterol (2-dimethylamino-6-[β diethylaminoethoxy]-benzothiazole) dihydrochloride, it was ascertained that there have been reported cases of Asterol intoxication consisting of neurotoxic symptoms due to absorption from topical applications. We believe we have the first case of neurotoxic symptoms in an infant that can be attributed to ingestion of Asterol. REPORT OF A CASE H. G., a white boy, aged 7 weeks, was admitted to the hospital on Sept. 9, 1953, with the history of convulsive seizures first occurring on the day of admission. The first seizure occurred at 7 a. m. while the patient was being breast-fed. It consisted of marked muscle tremors of his left eye, cheek, arm, side, and leg. The duration was approximately three minutes. The patient was examined by one of us (C. H. G.) in his office, where two seizures were observed. These involved the right side, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

NEUROTOXIC SYMPTOMS FOLLOWING INGESTION OF ASTEROL DIHYDROCHLORIDE

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1954.02050100201006
Publisher site
See Article on Publisher Site

Abstract

THROUGH communication with Hoffmann-LaRoche, Inc., manufacturers of the antifungal drug Asterol (2-dimethylamino-6-[β diethylaminoethoxy]-benzothiazole) dihydrochloride, it was ascertained that there have been reported cases of Asterol intoxication consisting of neurotoxic symptoms due to absorption from topical applications. We believe we have the first case of neurotoxic symptoms in an infant that can be attributed to ingestion of Asterol. REPORT OF A CASE H. G., a white boy, aged 7 weeks, was admitted to the hospital on Sept. 9, 1953, with the history of convulsive seizures first occurring on the day of admission. The first seizure occurred at 7 a. m. while the patient was being breast-fed. It consisted of marked muscle tremors of his left eye, cheek, arm, side, and leg. The duration was approximately three minutes. The patient was examined by one of us (C. H. G.) in his office, where two seizures were observed. These involved the right side,

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Aug 1, 1954

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