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NEUROSYPHILIS AND LATE SYPHILIS OF SKIN, MUCOUS MEMBRANES AND BONES

NEUROSYPHILIS AND LATE SYPHILIS OF SKIN, MUCOUS MEMBRANES AND BONES Abstract One of the tenets held over from the early days of syphilology which is still frequently accepted and taught is the belief that patients with late syphilis of the skin, mucous membrane or bone seldom have neurosyphilis. It is commonly believed that these manifestations of the disease are allergic in origin and influence the immunity reaction so as to protect the neuraxis against involvement by the Spirochaeta pallida. Except so-called "precocious tertiary" lesions of the skin, which are on the borderline between those of early and those of late syphilis, and acute syphilis of the bone, which may occur as a phase of early syphilis, these benign tertiary manifestations as a rule appear after the tenth year of the infection. However, as a result of the discovery that a large number of patients with early syphilis show changes in their spinal fluid due to neuraxis involvement, modern syphilologists agree that References 1. Keidel, A.: Studies in Asymptomatic Neurosyphilis: Apparent Rôle of Immunity in Genesis of Neurosyphilis , J. A. M. A. 79:874 ( (Sept. 9) ) 1922.Crossref 2. Chesney, A. M., and Kemp, J. E.: Incidence of Spirochaeta Pallida in Cerebrospinal Fluid During Early Stage of Syphilis , J. A. M. A. 83:1725 ( (Nov. 29) ) 1924.Crossref 3. Moore, J. E.: Syphilis, in Blumer, G.: The Practitioners Library of Medicine and Surgery , New York, D. Appleton-Century Company, Inc., 1936, vol. 10, p. 884. 4. Dercum, F. X.: The Clinical Forms Presented by Nervous Syphilis , New York M. J. 98:745, 1913. 5. Jeanselme, E.: Elephantiasis syphilitique du membre supérieur , Bull. Soc. franç. de dermat. et syph. 24:129, 1913. 6. Pollitzer, S.: Symposium on Syphilis , Post Graduate 28:729, 1913. 7. Bond, E. D.: Personal communication to C. J. White. 8. Hoffman, J. A.: A Report of the Patients Discharged from the John G. Kerr Hospital for Insane During 1912 , China M. J. 27:369, 1913 9. Insanity in China , Boston M. & S. J. 170:572, 1914. 10. White, C. J.: A Statistical Study of Syphilis: The Relation of Its Symptoms to Subsequent Tabes Dorsalis or General Paresis , J. A. M. A. 63:459 ( (Aug. 8) ) 1914. 11. Public Health Institute, Chicago. 12. Kemp, J. E., and Menninger, W. C.: The Influence of Pregnancy upon the Course of Syphilis , Brit. J. Ven. Dis. 12:206, 1936. 13. Menninger, W. C., and Kemp, J. E.: The Incidence of the Clinical Types of Neurosyphilis in Males, Pregnant and Non-Pregnant Females , J. Nerv. & Ment. Dis. 83:275, 1936. 14. Arzt, L., and Fuhs, H.: Liquor- und klinische Nervenveränderungen bei tertiärer Haut- (Schleimhaut-) Lues und ihre Beurteilung, hinsichtlich Prognose und Therapie , Arch. f. Dermat. u. Syph. 163:164, 1931 15. Liquor und tertiäre Haut-(Schleimhaut-) Lues , Arzt Arch. f. Dermat. u. Syph. 166:427, 1932 16. Manifeste Neurolues (Lues cerebrospinalis, Tabes, progressive Paralyse) bei Tertiäre Haut- (Schleimhaut-) Lues , Arzt Arch. f. Dermat. u. Syph. 166:234, 1932. 17. Hval, E.: Condition of Cerebrospinal Fluid in Gummatous Syphilis , Acta dermat.-venereol. 13:643, 1932. 18. O'Leary, P. A., and Rogin, J.: Late Cutaneous Syphilis , Am. J. Syph. 16:98, 1932. 19. Konrad, J.: Lues gummosa und Liquorveränderungen , Arch. f. Dermat. u. Syph. 162:102, 1930. 20. Grschebin, S.: Beitrag zur Frage nach der Entstehung der Neurolues , Arch. f. Dermat. u. Syph. 159:284, 1930. 21. Merenlender, J.: Gibt es einen Antagonismus zwischen Haut- und Metalues? Zentralbl. f. Haut- u. Geschlechtskr. 43:1, 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

NEUROSYPHILIS AND LATE SYPHILIS OF SKIN, MUCOUS MEMBRANES AND BONES

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Publisher
American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1940.01490150060010
Publisher site
See Article on Publisher Site

Abstract

Abstract One of the tenets held over from the early days of syphilology which is still frequently accepted and taught is the belief that patients with late syphilis of the skin, mucous membrane or bone seldom have neurosyphilis. It is commonly believed that these manifestations of the disease are allergic in origin and influence the immunity reaction so as to protect the neuraxis against involvement by the Spirochaeta pallida. Except so-called "precocious tertiary" lesions of the skin, which are on the borderline between those of early and those of late syphilis, and acute syphilis of the bone, which may occur as a phase of early syphilis, these benign tertiary manifestations as a rule appear after the tenth year of the infection. However, as a result of the discovery that a large number of patients with early syphilis show changes in their spinal fluid due to neuraxis involvement, modern syphilologists agree that References 1. Keidel, A.: Studies in Asymptomatic Neurosyphilis: Apparent Rôle of Immunity in Genesis of Neurosyphilis , J. A. M. A. 79:874 ( (Sept. 9) ) 1922.Crossref 2. Chesney, A. M., and Kemp, J. E.: Incidence of Spirochaeta Pallida in Cerebrospinal Fluid During Early Stage of Syphilis , J. A. M. A. 83:1725 ( (Nov. 29) ) 1924.Crossref 3. Moore, J. E.: Syphilis, in Blumer, G.: The Practitioners Library of Medicine and Surgery , New York, D. Appleton-Century Company, Inc., 1936, vol. 10, p. 884. 4. Dercum, F. X.: The Clinical Forms Presented by Nervous Syphilis , New York M. J. 98:745, 1913. 5. Jeanselme, E.: Elephantiasis syphilitique du membre supérieur , Bull. Soc. franç. de dermat. et syph. 24:129, 1913. 6. Pollitzer, S.: Symposium on Syphilis , Post Graduate 28:729, 1913. 7. Bond, E. D.: Personal communication to C. J. White. 8. Hoffman, J. A.: A Report of the Patients Discharged from the John G. Kerr Hospital for Insane During 1912 , China M. J. 27:369, 1913 9. Insanity in China , Boston M. & S. J. 170:572, 1914. 10. White, C. J.: A Statistical Study of Syphilis: The Relation of Its Symptoms to Subsequent Tabes Dorsalis or General Paresis , J. A. M. A. 63:459 ( (Aug. 8) ) 1914. 11. Public Health Institute, Chicago. 12. Kemp, J. E., and Menninger, W. C.: The Influence of Pregnancy upon the Course of Syphilis , Brit. J. Ven. Dis. 12:206, 1936. 13. Menninger, W. C., and Kemp, J. E.: The Incidence of the Clinical Types of Neurosyphilis in Males, Pregnant and Non-Pregnant Females , J. Nerv. & Ment. Dis. 83:275, 1936. 14. Arzt, L., and Fuhs, H.: Liquor- und klinische Nervenveränderungen bei tertiärer Haut- (Schleimhaut-) Lues und ihre Beurteilung, hinsichtlich Prognose und Therapie , Arch. f. Dermat. u. Syph. 163:164, 1931 15. Liquor und tertiäre Haut-(Schleimhaut-) Lues , Arzt Arch. f. Dermat. u. Syph. 166:427, 1932 16. Manifeste Neurolues (Lues cerebrospinalis, Tabes, progressive Paralyse) bei Tertiäre Haut- (Schleimhaut-) Lues , Arzt Arch. f. Dermat. u. Syph. 166:234, 1932. 17. Hval, E.: Condition of Cerebrospinal Fluid in Gummatous Syphilis , Acta dermat.-venereol. 13:643, 1932. 18. O'Leary, P. A., and Rogin, J.: Late Cutaneous Syphilis , Am. J. Syph. 16:98, 1932. 19. Konrad, J.: Lues gummosa und Liquorveränderungen , Arch. f. Dermat. u. Syph. 162:102, 1930. 20. Grschebin, S.: Beitrag zur Frage nach der Entstehung der Neurolues , Arch. f. Dermat. u. Syph. 159:284, 1930. 21. Merenlender, J.: Gibt es einen Antagonismus zwischen Haut- und Metalues? Zentralbl. f. Haut- u. Geschlechtskr. 43:1, 1932.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Sep 1, 1940

References