Letters 1. Barnes DE, Byers AL, Gardner RC, Seal KH, Boscardin WJ, Yaffe K. Association obtained were in advanced stages of the disease. This result of mild traumatic brain injury with and without loss of consciousness with suggests that the underlying pathophysiology of circadian al- dementia in us military veterans. JAMA Neurol. 2018;75(9):1055-1061. doi:10. terations in PD is not homogenous. Although the general pic- 1001/jamaneurol.2018.0815 ture of circadian dysfunction in PD is still poor and limited by 2. Sandsmark DK, Elliott JE, Lim MM. Sleep-wake disturbances after traumatic the small sample size of published studies, this neuropatho- brain injury: synthesis of human and animal studies. Sleep. 2017;40(5). logical heterogeneity matches with the physiological and phe- 3. Grima N, Ponsford J, Rajaratnam SM, Mansfield D, Pase MP. Sleep 3,4 disturbances in traumatic brain injury: a meta-analysis. J Clin Sleep Med. 2016;12 notypic heterogeneity in circadian alterations reported in PD. (3):419-428. doi:10.5664/jcsm.5598 Collectively, this study confirms and strengthens the re- 4. Gaziano JM, Concato J, Brophy M, et al. Million Veteran Program: cently growing evidence of a complex and heterogeneous a mega-biobank to study genetic influences on health and disease. J Clin Epidemiol. pathophysiology of circadian alterations in PD. A detailed
JAMA Neurology – American Medical Association
Published: Jan 3, 2019
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