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NEUROLOGIC MANIFESTATIONS IN VITAMIN G (B2) DEFICIENCY: AN EXPERIMENTAL STUDY IN DOGS

NEUROLOGIC MANIFESTATIONS IN VITAMIN G (B2) DEFICIENCY: AN EXPERIMENTAL STUDY IN DOGS Abstract A vast amount of experimental work has been done in the attempt to elucidate the rôle of dietary deficiencies in nervous disorders. No attempt will be made in this paper to review adequately the many important contributions in this field. However, no paper dealing with this subject can neglect mention of Eijkman,1 who in 1897 first described noninflammatory atrophic degeneration of the medullary sheaths of the peripheral nerves in hens fed polished rice. Since Eijkman's day, knowledge of deficiency diseases in general and of vitamin deficiencies in particular has been greatly advanced. It is now believed that there are at least three vitamin factors, in addition to other principles, which are essential for maintenance of the health of the nervous system. From the experimental standpoint, lesions in the nervous system have been produced through the absence of (a) the fat-soluble vitamin A, the precursor of which is carotene, (b References 1. Eijkman, C.: Eine Beri Beri-ähnliche Krankheit der Hühner , Virchows Arch. f. path. Anat. 148:523, 1897.Crossref 2. Mellanby, E.: The Experimental Production of Degeneration in the Spinal Cord , Brain 54:247 ( (Sept.) ) 1931.Crossref 3. Zimmerman, H. M.: Lesions of the Nervous System in Vitamin Deficiency: I. Rats on a Diet Low in Vitamin A , J. Exper. Med. 57:215 ( (Feb.) ) 1933.Crossref 4. Zimmerman, H. M., and Burack, E.: Lesions of the Nervous System Resulting from Deficiency of the Vitamin B Complex , Arch. Path. 13:207 ( (Feb.) ) 1932. 5. Goldberger, J.; Wheeler, G. A.; Lillie, R. D., and Rogers, L. M.: A Further Study of Experimental Blacktongue with Special Reference to the Blacktongue Preventive in Yeast , Pub. Health Rep. 43:657 ( (March) ) 1928.Crossref 6. Zimmerman, H. M.; Cowgill, G. R.; Bunnell, W. W., and Dann, M.: Studies on the Nervous System in Deficiency Diseases: Experimental Black Tongue , Am. J. Physiol. 109:440 ( (Sept.) ) 1934. 7. Zimmerman, H. M., and Burack, E.: Studies on the Nervous System in Deficiency Diseases: II. Lesions Produced in the Dog by Diets Lacking the Water-Soluble, Heat-Stable Vitamin B2 (G) , J. Exper. Med. 59:21 ( (Jan.) ) 1934.Crossref 8. Block, R. J., and Hubbell, R. B.: Studies on the Vitamin B Complex: Further Indications for the Presence of a Third Factor , Yale J. Biol. & Med. 8: 169 ( (Dec.) ) 1935. 9. Gildea, E. F.; Kattwinkel, E. E., and Castle, W. B.: Experimental Combined System Disease , New England J. Med. 202:523 ( (March 13) ) 1930.Crossref 10. Cowgill, G. R.: An Improved Procedure for Metabolism Experiments , J. Biol. Chem. 56:725 ( (July) ) 1923. 11. Block, R. J.; Cowgill, G. R., and Klotz, B. H.: The Antineuritic Vitamin: I. The Method of Assay, Concentration of the Vitamin with Silver Under Various Conditions, and Its Solubility in Certain Organic Solvents , J. Biol. Chem. 94:765 ( (Jan.) ) 1932. 12. The concentrate was furnished by Eli Lilly and Company. 13. Block, R. J., and Cowgill, G. R.: The Antineuritic Vitamin: III. Removal of Impurities by Fractional Precipitation , J. Biol. Chem. 97:421 ( (Aug.) ) 1932. 14. Stuart, E. H.; Block, R. J., and Cowgill, G. R.: The Antineuritic Vitamin: V. The Preparation of a Vitamin Concentrate Suitable for Parenteral Use , J. Biol. Chem. 105:463 ( (June) ) 1934. 15. White's cod liver oil concentrate was furnished by the Health Products Company, Newark, N. J. 16. Liver extract-Lilly was used. 17. This is the material prepared by Block from liver and is referred to in this paper 8 as product D used in the feeding experiments. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

NEUROLOGIC MANIFESTATIONS IN VITAMIN G (B2) DEFICIENCY: AN EXPERIMENTAL STUDY IN DOGS

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Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1937.02260140072004
Publisher site
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Abstract

Abstract A vast amount of experimental work has been done in the attempt to elucidate the rôle of dietary deficiencies in nervous disorders. No attempt will be made in this paper to review adequately the many important contributions in this field. However, no paper dealing with this subject can neglect mention of Eijkman,1 who in 1897 first described noninflammatory atrophic degeneration of the medullary sheaths of the peripheral nerves in hens fed polished rice. Since Eijkman's day, knowledge of deficiency diseases in general and of vitamin deficiencies in particular has been greatly advanced. It is now believed that there are at least three vitamin factors, in addition to other principles, which are essential for maintenance of the health of the nervous system. From the experimental standpoint, lesions in the nervous system have been produced through the absence of (a) the fat-soluble vitamin A, the precursor of which is carotene, (b References 1. Eijkman, C.: Eine Beri Beri-ähnliche Krankheit der Hühner , Virchows Arch. f. path. Anat. 148:523, 1897.Crossref 2. Mellanby, E.: The Experimental Production of Degeneration in the Spinal Cord , Brain 54:247 ( (Sept.) ) 1931.Crossref 3. Zimmerman, H. M.: Lesions of the Nervous System in Vitamin Deficiency: I. Rats on a Diet Low in Vitamin A , J. Exper. Med. 57:215 ( (Feb.) ) 1933.Crossref 4. Zimmerman, H. M., and Burack, E.: Lesions of the Nervous System Resulting from Deficiency of the Vitamin B Complex , Arch. Path. 13:207 ( (Feb.) ) 1932. 5. Goldberger, J.; Wheeler, G. A.; Lillie, R. D., and Rogers, L. M.: A Further Study of Experimental Blacktongue with Special Reference to the Blacktongue Preventive in Yeast , Pub. Health Rep. 43:657 ( (March) ) 1928.Crossref 6. Zimmerman, H. M.; Cowgill, G. R.; Bunnell, W. W., and Dann, M.: Studies on the Nervous System in Deficiency Diseases: Experimental Black Tongue , Am. J. Physiol. 109:440 ( (Sept.) ) 1934. 7. Zimmerman, H. M., and Burack, E.: Studies on the Nervous System in Deficiency Diseases: II. Lesions Produced in the Dog by Diets Lacking the Water-Soluble, Heat-Stable Vitamin B2 (G) , J. Exper. Med. 59:21 ( (Jan.) ) 1934.Crossref 8. Block, R. J., and Hubbell, R. B.: Studies on the Vitamin B Complex: Further Indications for the Presence of a Third Factor , Yale J. Biol. & Med. 8: 169 ( (Dec.) ) 1935. 9. Gildea, E. F.; Kattwinkel, E. E., and Castle, W. B.: Experimental Combined System Disease , New England J. Med. 202:523 ( (March 13) ) 1930.Crossref 10. Cowgill, G. R.: An Improved Procedure for Metabolism Experiments , J. Biol. Chem. 56:725 ( (July) ) 1923. 11. Block, R. J.; Cowgill, G. R., and Klotz, B. H.: The Antineuritic Vitamin: I. The Method of Assay, Concentration of the Vitamin with Silver Under Various Conditions, and Its Solubility in Certain Organic Solvents , J. Biol. Chem. 94:765 ( (Jan.) ) 1932. 12. The concentrate was furnished by Eli Lilly and Company. 13. Block, R. J., and Cowgill, G. R.: The Antineuritic Vitamin: III. Removal of Impurities by Fractional Precipitation , J. Biol. Chem. 97:421 ( (Aug.) ) 1932. 14. Stuart, E. H.; Block, R. J., and Cowgill, G. R.: The Antineuritic Vitamin: V. The Preparation of a Vitamin Concentrate Suitable for Parenteral Use , J. Biol. Chem. 105:463 ( (June) ) 1934. 15. White's cod liver oil concentrate was furnished by the Health Products Company, Newark, N. J. 16. Liver extract-Lilly was used. 17. This is the material prepared by Block from liver and is referred to in this paper 8 as product D used in the feeding experiments.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Feb 1, 1937

References