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Neurologic Complications of Tetanus Toxoid

Neurologic Complications of Tetanus Toxoid Abstract To the Editor. —Holliday and Bauer (Archives 1983;40:56-57) described a patient in whom polyradiculoneuritis, and possible myelitis, developed within hours of immunization with tetanus and diphtheria toxoids, claiming a cause-and-effect relationship. They indicated that neurologic complications of immunization with combined tetanus and diphtheria toxoids have not been reported and concluded that tetanus toxoid was probably responsible for the adverse reaction. In fact, there have been reports of transverse myelitis1 and encephalitis2 after immunization with diphtheria and tetanus toxoids, but the more important issue is whether the tetanus toxoid immunization in this and other reports was responsible for the subsequent neurologic disorder.The only link between the immunization and the polyradiculoneuritis was the temporal relationship. That is not a strong link, as it seems unlikely that a widespread allergic reaction of the nervous system would develop within hours of immunization in the absence of systemic symptoms. There are rare References 1. Whittle E, Roberton NRC: Transverse myelitis after diphtheria, tetanus, and polio immunisation . Br Med J 1977;1:1430-1431.Crossref 2. Ehrengut W: Ueber neurale Komplikationen nach diphterieschutzumpfung oder unipfungen mit Diphteriertoxoid-mischimpfstoffen . Monatsschr Kinderheilkd 1969;112:331-338. 3. Quast U, Hennessen W, Widmark RM: Mono- and polyneuritis after tetanus vaccination (1970-1977) . Dev Biol Stand 1979;43:25-32. 4. Pollard JD, Selby G: Relapsing neuropathy due to tetanus toxoid . J Neurol Sci 1978;37:113-125.Crossref 5. Jacobs RL, Lowe RS, Lanier BQ: Adverse reactions to tetanus toxoid . JAMA 1982;247:40-42.Crossref 6. Myers MG, Beckman CW, Vosdingh A, et al: Primary immunization with tetanus and diphtheria toxoids: Reaction rates and immunogenicity in older children and adults . JAMA 1982;248:2478-2480.Crossref 7. Fenichel GM: The pertussis vaccine controversy: The danger of case reports . Arch Neurol 1983;40:193-194.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Neurologic Complications of Tetanus Toxoid

Archives of Neurology , Volume 40 (6) – Jun 1, 1983

Neurologic Complications of Tetanus Toxoid

Abstract

Abstract To the Editor. —Holliday and Bauer (Archives 1983;40:56-57) described a patient in whom polyradiculoneuritis, and possible myelitis, developed within hours of immunization with tetanus and diphtheria toxoids, claiming a cause-and-effect relationship. They indicated that neurologic complications of immunization with combined tetanus and diphtheria toxoids have not been reported and concluded that tetanus toxoid was probably responsible for the adverse reaction. In fact, there...
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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1983.04050060090020
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —Holliday and Bauer (Archives 1983;40:56-57) described a patient in whom polyradiculoneuritis, and possible myelitis, developed within hours of immunization with tetanus and diphtheria toxoids, claiming a cause-and-effect relationship. They indicated that neurologic complications of immunization with combined tetanus and diphtheria toxoids have not been reported and concluded that tetanus toxoid was probably responsible for the adverse reaction. In fact, there have been reports of transverse myelitis1 and encephalitis2 after immunization with diphtheria and tetanus toxoids, but the more important issue is whether the tetanus toxoid immunization in this and other reports was responsible for the subsequent neurologic disorder.The only link between the immunization and the polyradiculoneuritis was the temporal relationship. That is not a strong link, as it seems unlikely that a widespread allergic reaction of the nervous system would develop within hours of immunization in the absence of systemic symptoms. There are rare References 1. Whittle E, Roberton NRC: Transverse myelitis after diphtheria, tetanus, and polio immunisation . Br Med J 1977;1:1430-1431.Crossref 2. Ehrengut W: Ueber neurale Komplikationen nach diphterieschutzumpfung oder unipfungen mit Diphteriertoxoid-mischimpfstoffen . Monatsschr Kinderheilkd 1969;112:331-338. 3. Quast U, Hennessen W, Widmark RM: Mono- and polyneuritis after tetanus vaccination (1970-1977) . Dev Biol Stand 1979;43:25-32. 4. Pollard JD, Selby G: Relapsing neuropathy due to tetanus toxoid . J Neurol Sci 1978;37:113-125.Crossref 5. Jacobs RL, Lowe RS, Lanier BQ: Adverse reactions to tetanus toxoid . JAMA 1982;247:40-42.Crossref 6. Myers MG, Beckman CW, Vosdingh A, et al: Primary immunization with tetanus and diphtheria toxoids: Reaction rates and immunogenicity in older children and adults . JAMA 1982;248:2478-2480.Crossref 7. Fenichel GM: The pertussis vaccine controversy: The danger of case reports . Arch Neurol 1983;40:193-194.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Jun 1, 1983

References

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