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Neurodevelopmental Outcomes of Extremely Low-Gestational-Age Neonates With Low-Grade Periventricular-Intraventricular Hemorrhage

Neurodevelopmental Outcomes of Extremely Low-Gestational-Age Neonates With Low-Grade... ARTICLE Neurodevelopmental Outcomes of Extremely Low-Gestational-Age Neonates With Low-Grade Periventricular-Intraventricular Hemorrhage Allison H. Payne, MD, MS; Susan R. Hintz, MD, MS; Anna Maria Hibbs, MD, MS; Michele C. Walsh, MD, MS; Betty R. Vohr, MD; Carla M. Bann, PhD; Deanne E. Wilson-Costello, MD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Importance: Low-grade periventricular-intraventricu- Main Outcome Measures: Outcomes included cere- lar hemorrhage is a common neurologic morbidity among bral palsy; gross motor functional limitation; cognitive and language scores according to the Bayley Scales of Infant De- extremely low-gestational-age neonates, yet the out- velopment, 3rd Edition; and composite measures of neu- comes associated with this morbidity are not fully un- rodevelopmental impairment. Regression modeling evalu- derstood. In a contemporary multicenter cohort, we evalu- ated the association of hemorrhage severity with adverse ated the impact of such hemorrhages on early (18-22 outcomes while controlling for potentially confounding vari- month) neurodevelopmental outcomes of extremely pre- ables and center differences. mature infants. Results: Low-grade hemorrhage was not associated with Objective: To compare neurodevelopmental outcomes significant differences in unadjusted or adjusted risk of any at 18 to 22 months’ corrected age for extremely low- adverse neurodevelopmental http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Neurodevelopmental Outcomes of Extremely Low-Gestational-Age Neonates With Low-Grade Periventricular-Intraventricular Hemorrhage

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2013.866
pmid
23460139
Publisher site
See Article on Publisher Site

Abstract

ARTICLE Neurodevelopmental Outcomes of Extremely Low-Gestational-Age Neonates With Low-Grade Periventricular-Intraventricular Hemorrhage Allison H. Payne, MD, MS; Susan R. Hintz, MD, MS; Anna Maria Hibbs, MD, MS; Michele C. Walsh, MD, MS; Betty R. Vohr, MD; Carla M. Bann, PhD; Deanne E. Wilson-Costello, MD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Importance: Low-grade periventricular-intraventricu- Main Outcome Measures: Outcomes included cere- lar hemorrhage is a common neurologic morbidity among bral palsy; gross motor functional limitation; cognitive and language scores according to the Bayley Scales of Infant De- extremely low-gestational-age neonates, yet the out- velopment, 3rd Edition; and composite measures of neu- comes associated with this morbidity are not fully un- rodevelopmental impairment. Regression modeling evalu- derstood. In a contemporary multicenter cohort, we evalu- ated the association of hemorrhage severity with adverse ated the impact of such hemorrhages on early (18-22 outcomes while controlling for potentially confounding vari- month) neurodevelopmental outcomes of extremely pre- ables and center differences. mature infants. Results: Low-grade hemorrhage was not associated with Objective: To compare neurodevelopmental outcomes significant differences in unadjusted or adjusted risk of any at 18 to 22 months’ corrected age for extremely low- adverse neurodevelopmental

Journal

JAMA PediatricsAmerican Medical Association

Published: May 1, 2013

References