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Neuroblastoma in Childhood

Neuroblastoma in Childhood Abstract SECOND only to accidents, cancer is the most frequent cause of death in children older than 1 year.1 In the California Tumor Registry neuroblastoma accounts for 5% of the childhood malignancies, and in children's centers 10% to 12% of the malignant neoplasms are neuroblastomas.2,3 This tumor is preceded in frequency only by leukemia and brain tumor. However, there are only five series of more than 90 patients reported. Cases of neuroblastoma recorded in the California Tumor Registry are reviewed in this paper. This series is compared with the other large series reported from single medical centers: namely, the Hospital for Sick Children, London; the Children's Medical Center, Boston; the Memorial Center for Cancer and Allied Diseases, New York; the Children's Hospital, Philadelphia; and the Children's Hospital, Columbus, Ohio.4-8 A synthesis of this material may provide a predicted biologic behavior of neuroblastoma, so that the effectiveness of newer References 1. Vital Statistics of the United States, 1959 , the National Office of Vital Statistics, Public Health Service, US Dept of Health, Education and Welfare. 2. Bill, A.H.; Hartmann, J.R.; and Beckwith, J.B.: The Unique Biology of Childhood Tumors With Special Reference to the Biology of Neuroblastoma , Pacific Med Surg 75:281-284 ( (Sept) -Oct) 1967. 3. Dargeon, M.W.: Tumors of Childhood , New York: Paul B. Hoeber, Inc., 1960, p 28. 4. Bodian, M.: Neuroblastoma , Pediat Clin N Amer 6:449-472 ( (May) ) 1959. 5. Gross, R.E.; Farber, S.; and Martin, L.W.: Neuroblastoma Sympatheticum: A Study and Report of 217 Cases , Pediatrics 23:1179-1191 ( (June) ) 1959. 6. Fortner, J.; Nicastri, A.; and Murphy, M.L.: Neuroblastoma: Natural History and Results of Treating 133 Cases , Ann Surg 167:132-142 ( (Jan) ) 1968.Crossref 7. Koop, C.E., and Hernandez, R.: Neuroblastoma: Experience With 100 Cases in Children , Surgery 56: 726-733 ( (Oct) ) 1964. 8. Priebe, C.J., and Clatworthy, H.W.: Neuroblastoma: Evaluation of the Treatment of 90 Children , Arch Surg 95:538-544 ( (Oct) ) 1967.Crossref 9. Collins, V.P.; Loeffler, R.K.; and Tivey, H.: Observations on Growth Rates of Human Tumors , Amer J Roentgen 76:988-1000 ( (Nov) ) 1956. 10. Sutow, W.W.: Prognosis in Neuroblastoma of Childhood , Amer J Dis Child 96:299-305 ( (Sept) ) 1958. 11. Cole, W.H., and Everson, T.C.: Spontaneous Regression of Cancer , Philadelphia: W. B. Saunders Co., 1966. 12. Bodian, M.: Neuroblastoma: An Evaluation of Its Natural History and the Effects of Therapy, With Particular Reference to Treatment by Massive Doses of Vitamin B12 , Arch Dis Child 38:606-618 ( (Dec) ) 1963.Crossref 13. Koop, C.E.: Neuroblastoma: Two Year Survival and Treatment Correlations , J Pediat Surg 3 ( (pt 2) ):178-179 (Feb) 1968.Crossref 14. James, D.H., et al: Combination Chemotherapy of Childhood Neuroblastoma , JAMA 194:123-126 ( (Oct 11) ) 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040443005
Publisher site
See Article on Publisher Site

Abstract

Abstract SECOND only to accidents, cancer is the most frequent cause of death in children older than 1 year.1 In the California Tumor Registry neuroblastoma accounts for 5% of the childhood malignancies, and in children's centers 10% to 12% of the malignant neoplasms are neuroblastomas.2,3 This tumor is preceded in frequency only by leukemia and brain tumor. However, there are only five series of more than 90 patients reported. Cases of neuroblastoma recorded in the California Tumor Registry are reviewed in this paper. This series is compared with the other large series reported from single medical centers: namely, the Hospital for Sick Children, London; the Children's Medical Center, Boston; the Memorial Center for Cancer and Allied Diseases, New York; the Children's Hospital, Philadelphia; and the Children's Hospital, Columbus, Ohio.4-8 A synthesis of this material may provide a predicted biologic behavior of neuroblastoma, so that the effectiveness of newer References 1. Vital Statistics of the United States, 1959 , the National Office of Vital Statistics, Public Health Service, US Dept of Health, Education and Welfare. 2. Bill, A.H.; Hartmann, J.R.; and Beckwith, J.B.: The Unique Biology of Childhood Tumors With Special Reference to the Biology of Neuroblastoma , Pacific Med Surg 75:281-284 ( (Sept) -Oct) 1967. 3. Dargeon, M.W.: Tumors of Childhood , New York: Paul B. Hoeber, Inc., 1960, p 28. 4. Bodian, M.: Neuroblastoma , Pediat Clin N Amer 6:449-472 ( (May) ) 1959. 5. Gross, R.E.; Farber, S.; and Martin, L.W.: Neuroblastoma Sympatheticum: A Study and Report of 217 Cases , Pediatrics 23:1179-1191 ( (June) ) 1959. 6. Fortner, J.; Nicastri, A.; and Murphy, M.L.: Neuroblastoma: Natural History and Results of Treating 133 Cases , Ann Surg 167:132-142 ( (Jan) ) 1968.Crossref 7. Koop, C.E., and Hernandez, R.: Neuroblastoma: Experience With 100 Cases in Children , Surgery 56: 726-733 ( (Oct) ) 1964. 8. Priebe, C.J., and Clatworthy, H.W.: Neuroblastoma: Evaluation of the Treatment of 90 Children , Arch Surg 95:538-544 ( (Oct) ) 1967.Crossref 9. Collins, V.P.; Loeffler, R.K.; and Tivey, H.: Observations on Growth Rates of Human Tumors , Amer J Roentgen 76:988-1000 ( (Nov) ) 1956. 10. Sutow, W.W.: Prognosis in Neuroblastoma of Childhood , Amer J Dis Child 96:299-305 ( (Sept) ) 1958. 11. Cole, W.H., and Everson, T.C.: Spontaneous Regression of Cancer , Philadelphia: W. B. Saunders Co., 1966. 12. Bodian, M.: Neuroblastoma: An Evaluation of Its Natural History and the Effects of Therapy, With Particular Reference to Treatment by Massive Doses of Vitamin B12 , Arch Dis Child 38:606-618 ( (Dec) ) 1963.Crossref 13. Koop, C.E.: Neuroblastoma: Two Year Survival and Treatment Correlations , J Pediat Surg 3 ( (pt 2) ):178-179 (Feb) 1968.Crossref 14. James, D.H., et al: Combination Chemotherapy of Childhood Neuroblastoma , JAMA 194:123-126 ( (Oct 11) ) 1965.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1969

References