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NERVE DEGENERATION IN POLIOMYELITIS: V. CORRELATION OF FIBER CHANGES IN NERVES WITH CELLULAR CHANGES IN THE SPINAL CORD

NERVE DEGENERATION IN POLIOMYELITIS: V. CORRELATION OF FIBER CHANGES IN NERVES WITH CELLULAR... Abstract The preceding papers of this series1 dealt with a correlation between histologic evidence of degenerative changes in the roots and nerves supplying the affected extremities in experimental acute poliomyelitis and physiologic data concerning the concurrent dysfunction. The problem was undertaken with the view that the condition of the mensurable physiologic properties of the nerve fiber is the best index to the functional state of its cell of origin. For the functional aspect of the study the cathode ray oscillograph was employed to record the physiologic properties of the nerves and roots in vitro. In addition galvanic stimulation was applied: (1) to the cord above the segments supplying the affected extremity, and (2) to the roots and nerves during the preparalytic stage and at intervals subsequent to the onset of paralysis. Standard neurohistologic procedures were also employed. In order to interpret results, it was necessary to secure quantitative data concerning References 1. Covell, W. P., and O'Leary, J. L.: Nerve Degeneration in Poliomyelitis: I. Vital Staining Methods with Neutral Red Applied to Nerve Degeneration , Arch. Neurol. & Psychiat. 27:518 ( (March) ) 1932. 2. Bishop, G. H.; Heinbecker P., and O'Leary, J. L.: Nerve Degeneration in Poliomyelitis: II. A Histologic and Functional Analysis of Normal Somatic and Autonomic Nerves of the Monkey , Arch. Neurol. & Psychiat. 27:1070 ( (May) ) 1932. 3. Heinbecker, P.; Bishop, G. H., and O'Leary, J. L.: Nerve Degeneration in Poliomyelitis: III. The Rate of Depression and Disappearance of the Components of the Conducted Action Potential in Severed Nerves; a Correlation with Histologic Evidence of Degeneration in the Several Groups of Fibers Essentially Responsible for the Various Components , Arch. Neurol. & Psychiat. 27:1421 ( (June) ) 1932. 4. O'Leary, J. L.; Heinbecker, P., and Bishop, G. H.: Nerve Degeneration in Poliomyelitis: IV. Physiologic and Histologic Studies on the Roots and Nerves Supplying Paralyzed Extremities of Monkeys during Acute Poliomyelitis , Arch. Neurol. & Psychiat. 28:272 ( (Aug.) ) 1932. 5. Covell, W. P.: Nuclear Changes of Nerve Cells in Acute Poliomyelitis , Proc. Soc. Exper. Biol. & Med. 27:927, 1930. 6. Hurst, E. W.: The Occurrence of Intranuclear Inclusions in the Nerve Cells in Poliomyelitis , J. Path. & Bact. 34:331, 1931. 7. Hurst, E. W.: The Histology of Experimental Poliomyelitis , J. Path. & Bact. 32:457, 1929. 8. Warburg, B.: Experimental Poliomyelitis: Histology of the Persistent Lesions of the Central Nervous System , Arch. Neurol. & Psychiat. 25:1191, ( (June) ) 1931. 9. Kubie, L. S.: A Study of the Perivascular Tissues of the Central Nervous System with Supravital Technique , J. Exper. Med. 46:615, 1927. 10. Horning, E. S., and Richardson, K. C.: Cytological Studies on Cellular Degeneration of Differentiated and Undifferentiated Tissues in Vitro , Australian J. Exper. Biol. & M. Sc. 6:229, 1929. 11. McCann, G. F.: A Study of Mitochondria in Experimental Poliomyelitis , J. Exper. Med. 27:31, 1918. 12. Kopits, I.: Beiträge zur Muskelpathologie: Histologische Befunde am Muskeln, Nerven und Blutgefässen in Spät und Endstadien peripher Lähmungen, mit besonderer Berücksichtigung der Poliomyelitis anterior acuta , Arch. f. orthop. u. Unfall-Chir. 27:277, 1929. 13. Opie, E. L.: The Enzymes in Phagocytic Cells of Inflammatory Exudates , J. Exper. Med. 8:410, 1906. 14. Carrel, A.: Growth Promoting Function of Leucocytes , J. Exper. Med. 36:385, 1922. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

NERVE DEGENERATION IN POLIOMYELITIS: V. CORRELATION OF FIBER CHANGES IN NERVES WITH CELLULAR CHANGES IN THE SPINAL CORD

Archives of Neurology & Psychiatry , Volume 28 (5) – Nov 1, 1932

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Publisher
American Medical Association
Copyright
Copyright © 1932 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1932.02240050090006
Publisher site
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Abstract

Abstract The preceding papers of this series1 dealt with a correlation between histologic evidence of degenerative changes in the roots and nerves supplying the affected extremities in experimental acute poliomyelitis and physiologic data concerning the concurrent dysfunction. The problem was undertaken with the view that the condition of the mensurable physiologic properties of the nerve fiber is the best index to the functional state of its cell of origin. For the functional aspect of the study the cathode ray oscillograph was employed to record the physiologic properties of the nerves and roots in vitro. In addition galvanic stimulation was applied: (1) to the cord above the segments supplying the affected extremity, and (2) to the roots and nerves during the preparalytic stage and at intervals subsequent to the onset of paralysis. Standard neurohistologic procedures were also employed. In order to interpret results, it was necessary to secure quantitative data concerning References 1. Covell, W. P., and O'Leary, J. L.: Nerve Degeneration in Poliomyelitis: I. Vital Staining Methods with Neutral Red Applied to Nerve Degeneration , Arch. Neurol. & Psychiat. 27:518 ( (March) ) 1932. 2. Bishop, G. H.; Heinbecker P., and O'Leary, J. L.: Nerve Degeneration in Poliomyelitis: II. A Histologic and Functional Analysis of Normal Somatic and Autonomic Nerves of the Monkey , Arch. Neurol. & Psychiat. 27:1070 ( (May) ) 1932. 3. Heinbecker, P.; Bishop, G. H., and O'Leary, J. L.: Nerve Degeneration in Poliomyelitis: III. The Rate of Depression and Disappearance of the Components of the Conducted Action Potential in Severed Nerves; a Correlation with Histologic Evidence of Degeneration in the Several Groups of Fibers Essentially Responsible for the Various Components , Arch. Neurol. & Psychiat. 27:1421 ( (June) ) 1932. 4. O'Leary, J. L.; Heinbecker, P., and Bishop, G. H.: Nerve Degeneration in Poliomyelitis: IV. Physiologic and Histologic Studies on the Roots and Nerves Supplying Paralyzed Extremities of Monkeys during Acute Poliomyelitis , Arch. Neurol. & Psychiat. 28:272 ( (Aug.) ) 1932. 5. Covell, W. P.: Nuclear Changes of Nerve Cells in Acute Poliomyelitis , Proc. Soc. Exper. Biol. & Med. 27:927, 1930. 6. Hurst, E. W.: The Occurrence of Intranuclear Inclusions in the Nerve Cells in Poliomyelitis , J. Path. & Bact. 34:331, 1931. 7. Hurst, E. W.: The Histology of Experimental Poliomyelitis , J. Path. & Bact. 32:457, 1929. 8. Warburg, B.: Experimental Poliomyelitis: Histology of the Persistent Lesions of the Central Nervous System , Arch. Neurol. & Psychiat. 25:1191, ( (June) ) 1931. 9. Kubie, L. S.: A Study of the Perivascular Tissues of the Central Nervous System with Supravital Technique , J. Exper. Med. 46:615, 1927. 10. Horning, E. S., and Richardson, K. C.: Cytological Studies on Cellular Degeneration of Differentiated and Undifferentiated Tissues in Vitro , Australian J. Exper. Biol. & M. Sc. 6:229, 1929. 11. McCann, G. F.: A Study of Mitochondria in Experimental Poliomyelitis , J. Exper. Med. 27:31, 1918. 12. Kopits, I.: Beiträge zur Muskelpathologie: Histologische Befunde am Muskeln, Nerven und Blutgefässen in Spät und Endstadien peripher Lähmungen, mit besonderer Berücksichtigung der Poliomyelitis anterior acuta , Arch. f. orthop. u. Unfall-Chir. 27:277, 1929. 13. Opie, E. L.: The Enzymes in Phagocytic Cells of Inflammatory Exudates , J. Exper. Med. 8:410, 1906. 14. Carrel, A.: Growth Promoting Function of Leucocytes , J. Exper. Med. 36:385, 1922.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Nov 1, 1932

References