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Nephrotoxicity of Cephalothin-Aminoglycoside Interactions

Nephrotoxicity of Cephalothin-Aminoglycoside Interactions Abstract To the Editor. —The article by Wade et al published in the Archives (1981;141:1789-1793) provides further verification of the nephrotoxicity of the cephalothin sodium-aminoglycoside interaction. The authors were unable to reconcile the protective effect of cephalothin on toxic reactions to aminoglycosides in the animal model with the published results in clinical trials that disclose a notable nephrotoxic effect of the combination.A possible explanation for this disparity stems from an article by Bloch et al1 that compared the protective effects of carbenicillin disodium and cephalothin on toxic reactions to aminoglycosides in Sprague-Dawley rats. They found that a substantial partial protection from toxic reactions occurred when doses of 500 mg/ kg of cephalothin sodium and 100 mg/ kg of carbenicillin disodium were used. Cephalothin imparted protection only at a dose far in excess of that used clinically, whereas carbenicillin was effective at a dose within range of that normally used References 1. Bloch R, Luft FC, Rankin LI, et al: Protection from gentamicin nephrotoxicity by cephalothin and carbenicillin. Antimicrob Agents Chemother 1979;15:46-49.Crossref 2. Giamarellou H, Metzikoff CH, Papachristophorou S, et al: Prospective comparative evaluation of gentamicin or gentamicin plus cephalothin in the production of nephrotoxicity in man. J Antimicrob Chemother 1979;5:581-590.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Nephrotoxicity of Cephalothin-Aminoglycoside Interactions

Archives of Internal Medicine , Volume 142 (9) – Sep 1, 1982

Nephrotoxicity of Cephalothin-Aminoglycoside Interactions

Abstract

Abstract To the Editor. —The article by Wade et al published in the Archives (1981;141:1789-1793) provides further verification of the nephrotoxicity of the cephalothin sodium-aminoglycoside interaction. The authors were unable to reconcile the protective effect of cephalothin on toxic reactions to aminoglycosides in the animal model with the published results in clinical trials that disclose a notable nephrotoxic effect of the combination.A possible explanation for this disparity stems...
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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340220182031
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —The article by Wade et al published in the Archives (1981;141:1789-1793) provides further verification of the nephrotoxicity of the cephalothin sodium-aminoglycoside interaction. The authors were unable to reconcile the protective effect of cephalothin on toxic reactions to aminoglycosides in the animal model with the published results in clinical trials that disclose a notable nephrotoxic effect of the combination.A possible explanation for this disparity stems from an article by Bloch et al1 that compared the protective effects of carbenicillin disodium and cephalothin on toxic reactions to aminoglycosides in Sprague-Dawley rats. They found that a substantial partial protection from toxic reactions occurred when doses of 500 mg/ kg of cephalothin sodium and 100 mg/ kg of carbenicillin disodium were used. Cephalothin imparted protection only at a dose far in excess of that used clinically, whereas carbenicillin was effective at a dose within range of that normally used References 1. Bloch R, Luft FC, Rankin LI, et al: Protection from gentamicin nephrotoxicity by cephalothin and carbenicillin. Antimicrob Agents Chemother 1979;15:46-49.Crossref 2. Giamarellou H, Metzikoff CH, Papachristophorou S, et al: Prospective comparative evaluation of gentamicin or gentamicin plus cephalothin in the production of nephrotoxicity in man. J Antimicrob Chemother 1979;5:581-590.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 1, 1982

References