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Neovascular Glaucoma After Photoradiation Therapy for Uveal Melanoma

Neovascular Glaucoma After Photoradiation Therapy for Uveal Melanoma Abstract • We describe two patients (two eyes) with neovascular glaucoma following photoradiation therapy (PRT) for ciliary body and iris melanoma. Histopathologic examination in one eye eight months after treatment disclosed widespread tumor necrosis. The second patient with iris melanoma showed total clinical disappearance of the lesion and regression of iris neovascularization six months later. The cause of the neovascular glaucoma is uncertain. The marked tumor necrosis induced by PRT might have resulted in release of a vasoproliferative factor that, in turn, led to the development of rubeosis and neovascular glaucoma. References 1. Dougherty TJ, Kaufman JE, Goldfarb A, et al: Photoradiation therapy for the treatment of malignant tumors . Cancer Res 1978;38:2628-2635. 2. Liu LHS, Ni C: Hematoporphyrin phototherapy for experimental intraocular malignant melanoma . Arch Ophthalmol 1983;101:901-903.Crossref 3. Sery TW: Photodynamic killing of retinoblastoma cells with hematoporphyrin and light . Cancer Res 1979;39:96-100. 4. Dougherty TJ: Activated dyes as anti tumor agents . JNCI 1974;51:1333-1338. 5. Gomer CJ, Dougherty TJ: Determination of 3H- and 14C hematoporphyrin derivative distribution in malignant and normal tissues . Cancer Res 1979;39:146-151. 6. Henderson BW, Dougherty TJ: Studies on the mechanism of tumor destruction by photoradiation therapy (PRT). Program and abstracts of the Clayton Foundation Symposium on Porphyrin Localization and Treatment of Tumors, Santa Barbara, Calif, April 24-28, 1983. 7. Weishaupt KR, Gomer CJ, Dougherty TJ: Identification of a singlet oxygen as the cytotoxic agent in photoinactivation of a musine tumor . Cancer Res 1976;36:2316-2329. 8. Gartner S, Henkind P: Neovascularization of the iris (rubeosis iridis) . Surv Ophthalmol 1978;22:291-312.Crossref 9. Schulze RR: Rubeosis iridis . Am J Ophthalmol 1967;63:487-497. 10. Cappin JM: Malignant melanoma and rubeosis iridis . Br J Ophthalmol 1973;57:815-824.Crossref 11. Yanoff M: Mechanism of glaucoma in eyes with uveal melanoma . Int Ophthalmol Clin 1972; 12:51-62. 12. Yanoff M: Glaucoma mechanisms in ocular malignant melanomas . Am J Ophthalmol 1980; 70:898-904. 13. Bujara K: Necrotic malignant melanomas of the choroid and ciliary body: A clinicopathological and statistical study . Graefes Arch Clin Exp Ophthalmol 1982;219:40-43.Crossref 14. Seddon JM, Gragoudas ES, Albert DM: Ciliary body and choroidal melanomas treated by proton beam irradiation: Histopathologic study of eyes . Arch Ophthalmol 1983;101:1402-1408.Crossref 15. Char DH, Saunders WM, Gregoudas ES: Charged particle (helium ion and proton) therapy . Ophthalmic Forum 1983;1:42-44. 16. Henkind P: Ocular neovascularization . Am J Ophthalmol 1978;85:287-301. 17. Kolker AE, Hetherington J Jr: Becker-Shaffer's Diagnosis and Therapy of the Glaucomas , ed 5, St Louis, CV Mosby Co, 1983. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Neovascular Glaucoma After Photoradiation Therapy for Uveal Melanoma

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030659012
Publisher site
See Article on Publisher Site

Abstract

Abstract • We describe two patients (two eyes) with neovascular glaucoma following photoradiation therapy (PRT) for ciliary body and iris melanoma. Histopathologic examination in one eye eight months after treatment disclosed widespread tumor necrosis. The second patient with iris melanoma showed total clinical disappearance of the lesion and regression of iris neovascularization six months later. The cause of the neovascular glaucoma is uncertain. The marked tumor necrosis induced by PRT might have resulted in release of a vasoproliferative factor that, in turn, led to the development of rubeosis and neovascular glaucoma. References 1. Dougherty TJ, Kaufman JE, Goldfarb A, et al: Photoradiation therapy for the treatment of malignant tumors . Cancer Res 1978;38:2628-2635. 2. Liu LHS, Ni C: Hematoporphyrin phototherapy for experimental intraocular malignant melanoma . Arch Ophthalmol 1983;101:901-903.Crossref 3. Sery TW: Photodynamic killing of retinoblastoma cells with hematoporphyrin and light . Cancer Res 1979;39:96-100. 4. Dougherty TJ: Activated dyes as anti tumor agents . JNCI 1974;51:1333-1338. 5. Gomer CJ, Dougherty TJ: Determination of 3H- and 14C hematoporphyrin derivative distribution in malignant and normal tissues . Cancer Res 1979;39:146-151. 6. Henderson BW, Dougherty TJ: Studies on the mechanism of tumor destruction by photoradiation therapy (PRT). Program and abstracts of the Clayton Foundation Symposium on Porphyrin Localization and Treatment of Tumors, Santa Barbara, Calif, April 24-28, 1983. 7. Weishaupt KR, Gomer CJ, Dougherty TJ: Identification of a singlet oxygen as the cytotoxic agent in photoinactivation of a musine tumor . Cancer Res 1976;36:2316-2329. 8. Gartner S, Henkind P: Neovascularization of the iris (rubeosis iridis) . Surv Ophthalmol 1978;22:291-312.Crossref 9. Schulze RR: Rubeosis iridis . Am J Ophthalmol 1967;63:487-497. 10. Cappin JM: Malignant melanoma and rubeosis iridis . Br J Ophthalmol 1973;57:815-824.Crossref 11. Yanoff M: Mechanism of glaucoma in eyes with uveal melanoma . Int Ophthalmol Clin 1972; 12:51-62. 12. Yanoff M: Glaucoma mechanisms in ocular malignant melanomas . Am J Ophthalmol 1980; 70:898-904. 13. Bujara K: Necrotic malignant melanomas of the choroid and ciliary body: A clinicopathological and statistical study . Graefes Arch Clin Exp Ophthalmol 1982;219:40-43.Crossref 14. Seddon JM, Gragoudas ES, Albert DM: Ciliary body and choroidal melanomas treated by proton beam irradiation: Histopathologic study of eyes . Arch Ophthalmol 1983;101:1402-1408.Crossref 15. Char DH, Saunders WM, Gregoudas ES: Charged particle (helium ion and proton) therapy . Ophthalmic Forum 1983;1:42-44. 16. Henkind P: Ocular neovascularization . Am J Ophthalmol 1978;85:287-301. 17. Kolker AE, Hetherington J Jr: Becker-Shaffer's Diagnosis and Therapy of the Glaucomas , ed 5, St Louis, CV Mosby Co, 1983.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1984

References