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Neonate Showing Reversible Splenial Lesion—Reply

Neonate Showing Reversible Splenial Lesion—Reply In reply Dr Takanashi's neonatal patient also shows splenium signal changes with an increased diffusion-weighted image signal and a decreased ADC value. Neonatal brain magnetic resonance imaging at Swedish Medical Center, Seattle, Wash, a busy birthing center, shows that perinatal asphyxia, germinal matrix hemorrhage, ischemic stroke, or neonatal seizure rarely results in splenium signal change. Takanashi et al's findings are intriguing and may suggest that myelin may have nothing to do with why diffusion-weighted image signals are altered. As most patients improve clinically, proving inflammatory involvement will likely remain difficult. Perhaps their neonate had a genetic risk similar to a recently described patient1 with a splenium signal change? This patient showed a mitochondrial mutation within an adenosine triphosphate synthesis gene. I wonder if an adenosine triphosphate synthesis defect might also have predisposed the patient of Takanashi et al to neonatal asphyxia. Back to top Article Information Correspondence: Dr Doherty, Swedish Epilepsy Center, 801 Broadway, Suite 901, Seattle, WA 98122 (michael.doherty@swedish.org). References 1. Shiihara TKato MHayasaka K Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology 2005;641487PubMedGoogle ScholarCrossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Neonate Showing Reversible Splenial Lesion—Reply

Archives of Neurology , Volume 62 (9) – Sep 1, 2005

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Publisher
American Medical Association
Copyright
Copyright © 2005 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.62.9.1482
Publisher site
See Article on Publisher Site

Abstract

In reply Dr Takanashi's neonatal patient also shows splenium signal changes with an increased diffusion-weighted image signal and a decreased ADC value. Neonatal brain magnetic resonance imaging at Swedish Medical Center, Seattle, Wash, a busy birthing center, shows that perinatal asphyxia, germinal matrix hemorrhage, ischemic stroke, or neonatal seizure rarely results in splenium signal change. Takanashi et al's findings are intriguing and may suggest that myelin may have nothing to do with why diffusion-weighted image signals are altered. As most patients improve clinically, proving inflammatory involvement will likely remain difficult. Perhaps their neonate had a genetic risk similar to a recently described patient1 with a splenium signal change? This patient showed a mitochondrial mutation within an adenosine triphosphate synthesis gene. I wonder if an adenosine triphosphate synthesis defect might also have predisposed the patient of Takanashi et al to neonatal asphyxia. Back to top Article Information Correspondence: Dr Doherty, Swedish Epilepsy Center, 801 Broadway, Suite 901, Seattle, WA 98122 (michael.doherty@swedish.org). References 1. Shiihara TKato MHayasaka K Clinically mild encephalitis/encephalopathy with a reversible splenial lesion. Neurology 2005;641487PubMedGoogle ScholarCrossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Sep 1, 2005

Keywords: newborn

References