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Neonatal Sepsis Evaluation

Neonatal Sepsis Evaluation Opinion EDITORIAL Facing the Certainty of Uncertainty Karen M. Puopolo, MD, PhD; Gabriel J. Escobar, MD In 2007, we began a National Institutes of Health–funded study issue of JAMA Pediatrics, several other investigators have of neonatal early-onset sepsis (EOS) whose goal was to de- performed retrospective medical record analyses or prospective implementation studies to address the clinical performance of velop multivariate predictive models that could be used by cli- nicians to evaluate a newborn’s risk of EOS. We approached the calculator models. Achten and colleagues concluded that this study with 3 objectives. the use of this quantitative approach to neonatal EOS risk is First, we would evaluate the associated with decreased antibiotic use compared with prior Related article page 1032 statistical association of indi- approaches, without concern that the approach fails to identify vidual, established risk factors for neonatal EOS with the out- significant numbers of newborns with EOS. come of culture-confirmed infection. Second, we would use We are glad that clinicians have approached use of the neo- routinely captured, objective data that could be found in an natal EOS calculator with an interest in both performance and electronic medical record. Third, we would determine whether safety. Although we http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Neonatal Sepsis Evaluation

JAMA Pediatrics , Volume 173 (11) – Nov 3, 2019

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References (16)

Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/jamapediatrics.2019.2832
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Facing the Certainty of Uncertainty Karen M. Puopolo, MD, PhD; Gabriel J. Escobar, MD In 2007, we began a National Institutes of Health–funded study issue of JAMA Pediatrics, several other investigators have of neonatal early-onset sepsis (EOS) whose goal was to de- performed retrospective medical record analyses or prospective implementation studies to address the clinical performance of velop multivariate predictive models that could be used by cli- nicians to evaluate a newborn’s risk of EOS. We approached the calculator models. Achten and colleagues concluded that this study with 3 objectives. the use of this quantitative approach to neonatal EOS risk is First, we would evaluate the associated with decreased antibiotic use compared with prior Related article page 1032 statistical association of indi- approaches, without concern that the approach fails to identify vidual, established risk factors for neonatal EOS with the out- significant numbers of newborns with EOS. come of culture-confirmed infection. Second, we would use We are glad that clinicians have approached use of the neo- routinely captured, objective data that could be found in an natal EOS calculator with an interest in both performance and electronic medical record. Third, we would determine whether safety. Although we

Journal

JAMA PediatricsAmerican Medical Association

Published: Nov 3, 2019

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