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Opinion EDITORIAL Facing the Certainty of Uncertainty Karen M. Puopolo, MD, PhD; Gabriel J. Escobar, MD In 2007, we began a National Institutes of Health–funded study issue of JAMA Pediatrics, several other investigators have of neonatal early-onset sepsis (EOS) whose goal was to de- performed retrospective medical record analyses or prospective implementation studies to address the clinical performance of velop multivariate predictive models that could be used by cli- nicians to evaluate a newborn’s risk of EOS. We approached the calculator models. Achten and colleagues concluded that this study with 3 objectives. the use of this quantitative approach to neonatal EOS risk is First, we would evaluate the associated with decreased antibiotic use compared with prior Related article page 1032 statistical association of indi- approaches, without concern that the approach fails to identify vidual, established risk factors for neonatal EOS with the out- significant numbers of newborns with EOS. come of culture-confirmed infection. Second, we would use We are glad that clinicians have approached use of the neo- routinely captured, objective data that could be found in an natal EOS calculator with an interest in both performance and electronic medical record. Third, we would determine whether safety. Although we
JAMA Pediatrics – American Medical Association
Published: Nov 3, 2019
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