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Neonatal Lupus Syndrome

Neonatal Lupus Syndrome Abstract • Neonatal lupus erythematosus Is a rare syndrome occurring in the first six months of life. It Is characterized by the presence of Ro antibodies in the mother and affected infant, and at least one clinical manifestation—cardiac, hematologic, or dermatologic. If present, congenital heart block is Irreversible and may be life-threatening in the neonatal period. Mothers of infants with neonatal lupus erythematosus may be asymptomatic when the affected infant is born but may later develop connective-tissue disease. The affected infants are at risk to develop systemic lupus erythematosus during adolescence or adulthood. (AJDC 1987;141:908-910) References 1. Alspaugh MA, Norman T, Tan EM: Differentiation and characterization of autoantibodies and their antigens in Sjogren's syndrome . Arthritis Rheum 1976;19:216-222.Crossref 2. McCuistion CH, Schoch EP Jr: Possible discoid lupus erythematosus in newborn infant . Arch Dermatol Syphilol 1954;70:782-785.Crossref 3. Michaelsson M, Engle MA: Congenital complete heart block: An international study of the natural history . Cardiovasc Clin 1972;4:85-101. 4. Scott JS, Maddison PJ, Taylor PV, et al: Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block . N Engl J Med 1983;309:209-212.Crossref 5. Lee LA, Lillis PJ, Fritz KA, et al: Neonatal lupus syndrome in successive pregnancies . J Am Acad Dermatol 1983;9:401-406.Crossref 6. Vonderheid EC, Koblenzer PJ, Ming PML, et al: Neonatal lupus erythematosus . Arch Dermatol 1976;112:698-705.Crossref 7. Winkler RB, Nora AH, Nora JJ: Familial congenital complete heart block and maternal systemic lupus erythematosus . Circulation 1977;56:1103-1106.Crossref 8. Chameides L, Truex RC, Vetter V, et al: Association of maternal systemic lupus erythematosus with congenital complete heart block . N Engl J Med 1977;297:1204-1207.Crossref 9. Hull D, Binns BAO, Joyce D: Congenital heart block and widespread fibrosis due to maternal lupus erythematosus . Arch Dis Child 1966;41: 688-690.Crossref 10. McCue CM, Mantakas ME, Tingelstad JB, et al: Congenital heart block in newborns of mothers with connective tissue disease . Circulation 1977;56:82-90.Crossref 11. Mattioli M, Reichlin M: Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus . Arthritis Rheum 1974;17:421-429.Crossref 12. Deng JS, Sontheimer RD, Gilliam JN: Molecular characteristics of SS-B/La and SS-A/Ro cellular antigens . J Invest Dermatol 1985;84:86-90.Crossref 13. Reichlin M, Wasicek CA: Clinical and biologic significance of antibodies to Ro/SSA . Hum Pathol 1983;14:401-405.Crossref 14. Harmon CE, Lee LA, Huff JC, et al: The frequency of antibodies to the SS-A/Ro antigen in pregnancy sera , abstracted. Arhtritis Rheum 1984;27( (suppl 4) ):S20.Crossref 15. Wasicek CA, Reichlin M: Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with Ro and La . J Clin Invest 1982;69:835-843.Crossref 16. Maddison PJ, Provost TT, Reichlin M: Serological findings in patients with 'ANA negative' systemic lupus erythematosus . Medicine 1981;60:87-94.Crossref 17. Sontheimer RD, Stastny P, Maddison PJ, et al: Anti-Ro and anti-La antibodies and further HLA associations in subacute cutaneous lupus erythematosus , abstracted. Arthritis Rheum 1980;23:80. 18. Watson RM, Braunstein BL, Watson AJ, et al: Fetal wastage in women with Anti-Ro(SSA) antibody . J Rheumatol 1986;13:90-94. 19. Esscher E, Scott JS: Congenital hear block and maternal systemic lupus erythemato[ill] sus . Br Med J 1979;1:1235-1238.Crossref 20. Watson RM, Lane AT, Barnett NK, et al Neonatal lupus erythematosus—A: Clinical serological and immunogenetic study with review of the literature . Medicine 1984;63:362-378.Crossref 21. Lee LA, Bias WB, Arnett FC Jr: Immu[ill] nogenetics of the neonatal lupus syndrome . An[ill] Intern Med 1983;99:592-596.Crossref 22. Lee LA, Harmon CE, Huff JC, et al[ill] SSA(Ro) antigen expression in human fetal, neo[ill] natal and adult tissues , abstracted. Arthriti[ill] Rheum 1984;27( (suppl 4) ):S20.Crossref 23. Litsey SE, Noonan JA, O'Connor WN et al: Maternal connective tissue disease an[ill] congenital heart block . N Engl J Med 1985;31298-100.Crossref 24. Lane AT, Watson RM: Neonatal lupus erythematosus . AJDC 1984;138:663-666. 25. Seip M: Systemic lupus erythematosus in pregnancy with haemolytic anemia, leukopenia and thrombocytopenia in the mother and her newborn infant . Arch Dis Child 1960;35:364-366.Crossref 26. Fox JR Jr, McCuistion CH, Schock EP Jr: Systemic lupus erythematosus: Association with previous neonatal lupus erythematosus . Arch Dermatol 1979;115:340.Crossref 27. Jackson R, Gulliver M: Neonatal lupus erythematosus progressing into systemic lupus erythematosus . Br J Dermatol 1979;101:81-86.Crossref 28. Lanham JG, Walport MJ, Hughes GV: Congenital heart block and familial connective tissue disease . J Rheumatol 1983;10:823-825. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460080094037
Publisher site
See Article on Publisher Site

Abstract

Abstract • Neonatal lupus erythematosus Is a rare syndrome occurring in the first six months of life. It Is characterized by the presence of Ro antibodies in the mother and affected infant, and at least one clinical manifestation—cardiac, hematologic, or dermatologic. If present, congenital heart block is Irreversible and may be life-threatening in the neonatal period. Mothers of infants with neonatal lupus erythematosus may be asymptomatic when the affected infant is born but may later develop connective-tissue disease. The affected infants are at risk to develop systemic lupus erythematosus during adolescence or adulthood. (AJDC 1987;141:908-910) References 1. Alspaugh MA, Norman T, Tan EM: Differentiation and characterization of autoantibodies and their antigens in Sjogren's syndrome . Arthritis Rheum 1976;19:216-222.Crossref 2. McCuistion CH, Schoch EP Jr: Possible discoid lupus erythematosus in newborn infant . Arch Dermatol Syphilol 1954;70:782-785.Crossref 3. Michaelsson M, Engle MA: Congenital complete heart block: An international study of the natural history . Cardiovasc Clin 1972;4:85-101. 4. Scott JS, Maddison PJ, Taylor PV, et al: Connective-tissue disease, antibodies to ribonucleoprotein, and congenital heart block . N Engl J Med 1983;309:209-212.Crossref 5. Lee LA, Lillis PJ, Fritz KA, et al: Neonatal lupus syndrome in successive pregnancies . J Am Acad Dermatol 1983;9:401-406.Crossref 6. Vonderheid EC, Koblenzer PJ, Ming PML, et al: Neonatal lupus erythematosus . Arch Dermatol 1976;112:698-705.Crossref 7. Winkler RB, Nora AH, Nora JJ: Familial congenital complete heart block and maternal systemic lupus erythematosus . Circulation 1977;56:1103-1106.Crossref 8. Chameides L, Truex RC, Vetter V, et al: Association of maternal systemic lupus erythematosus with congenital complete heart block . N Engl J Med 1977;297:1204-1207.Crossref 9. Hull D, Binns BAO, Joyce D: Congenital heart block and widespread fibrosis due to maternal lupus erythematosus . Arch Dis Child 1966;41: 688-690.Crossref 10. McCue CM, Mantakas ME, Tingelstad JB, et al: Congenital heart block in newborns of mothers with connective tissue disease . Circulation 1977;56:82-90.Crossref 11. Mattioli M, Reichlin M: Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus . Arthritis Rheum 1974;17:421-429.Crossref 12. Deng JS, Sontheimer RD, Gilliam JN: Molecular characteristics of SS-B/La and SS-A/Ro cellular antigens . J Invest Dermatol 1985;84:86-90.Crossref 13. Reichlin M, Wasicek CA: Clinical and biologic significance of antibodies to Ro/SSA . Hum Pathol 1983;14:401-405.Crossref 14. Harmon CE, Lee LA, Huff JC, et al: The frequency of antibodies to the SS-A/Ro antigen in pregnancy sera , abstracted. Arhtritis Rheum 1984;27( (suppl 4) ):S20.Crossref 15. Wasicek CA, Reichlin M: Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with Ro and La . J Clin Invest 1982;69:835-843.Crossref 16. Maddison PJ, Provost TT, Reichlin M: Serological findings in patients with 'ANA negative' systemic lupus erythematosus . Medicine 1981;60:87-94.Crossref 17. Sontheimer RD, Stastny P, Maddison PJ, et al: Anti-Ro and anti-La antibodies and further HLA associations in subacute cutaneous lupus erythematosus , abstracted. Arthritis Rheum 1980;23:80. 18. Watson RM, Braunstein BL, Watson AJ, et al: Fetal wastage in women with Anti-Ro(SSA) antibody . J Rheumatol 1986;13:90-94. 19. Esscher E, Scott JS: Congenital hear block and maternal systemic lupus erythemato[ill] sus . Br Med J 1979;1:1235-1238.Crossref 20. Watson RM, Lane AT, Barnett NK, et al Neonatal lupus erythematosus—A: Clinical serological and immunogenetic study with review of the literature . Medicine 1984;63:362-378.Crossref 21. Lee LA, Bias WB, Arnett FC Jr: Immu[ill] nogenetics of the neonatal lupus syndrome . An[ill] Intern Med 1983;99:592-596.Crossref 22. Lee LA, Harmon CE, Huff JC, et al[ill] SSA(Ro) antigen expression in human fetal, neo[ill] natal and adult tissues , abstracted. Arthriti[ill] Rheum 1984;27( (suppl 4) ):S20.Crossref 23. Litsey SE, Noonan JA, O'Connor WN et al: Maternal connective tissue disease an[ill] congenital heart block . N Engl J Med 1985;31298-100.Crossref 24. Lane AT, Watson RM: Neonatal lupus erythematosus . AJDC 1984;138:663-666. 25. Seip M: Systemic lupus erythematosus in pregnancy with haemolytic anemia, leukopenia and thrombocytopenia in the mother and her newborn infant . Arch Dis Child 1960;35:364-366.Crossref 26. Fox JR Jr, McCuistion CH, Schock EP Jr: Systemic lupus erythematosus: Association with previous neonatal lupus erythematosus . Arch Dermatol 1979;115:340.Crossref 27. Jackson R, Gulliver M: Neonatal lupus erythematosus progressing into systemic lupus erythematosus . Br J Dermatol 1979;101:81-86.Crossref 28. Lanham JG, Walport MJ, Hughes GV: Congenital heart block and familial connective tissue disease . J Rheumatol 1983;10:823-825.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1987

References

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