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Neonatal Lupus Erythematosus Syndrome-Reply

Neonatal Lupus Erythematosus Syndrome-Reply Abstract In Reply.— Neonatal lupus erythematosus (NLE) is a relatively recently described syndrome1 manifesting two major clinical features (congenital heart block and/or lupus dermatitis), several minor clinical features (including thrombocytopenia in 10% of those observed), and a serologic marker, the Ro antibody system (SSA). While definitive criteria for the diagnosis of systemic lupus erythematosus exists, this is not the case for the more recently described NLE syndrome.The object of our report was to stress evaluation of infants with thrombocytopenia of undetermined cause, and their mothers, for Ro antibody. We stressed the absence of the two major features of NLE and the presence of the Ro antibody system in our two infants. Our report "suggests that thrombocytopenia in our patients is a manifestation of the NLE syndrome."The authors felt it presumptive to make the diagnosis of NLE in the absence of complete heart block and lupus dermatitis. Our experience in References 1. McCuistion CH, Schock EP: Possible discoid lupus erythematosus in newborn infant . Arch Dermatol 1954;70:782-784. 2. Provost TT, Watson RM, Gammon WR: The neonatal lupus syndrome associated with U,RNP (nRNP) antibodies . N Engl J Med 1987;316:1135-1138.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Neonatal Lupus Erythematosus Syndrome-Reply

Archives of Dermatology , Volume 124 (12) – Dec 1, 1988

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670120075020
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply.— Neonatal lupus erythematosus (NLE) is a relatively recently described syndrome1 manifesting two major clinical features (congenital heart block and/or lupus dermatitis), several minor clinical features (including thrombocytopenia in 10% of those observed), and a serologic marker, the Ro antibody system (SSA). While definitive criteria for the diagnosis of systemic lupus erythematosus exists, this is not the case for the more recently described NLE syndrome.The object of our report was to stress evaluation of infants with thrombocytopenia of undetermined cause, and their mothers, for Ro antibody. We stressed the absence of the two major features of NLE and the presence of the Ro antibody system in our two infants. Our report "suggests that thrombocytopenia in our patients is a manifestation of the NLE syndrome."The authors felt it presumptive to make the diagnosis of NLE in the absence of complete heart block and lupus dermatitis. Our experience in References 1. McCuistion CH, Schock EP: Possible discoid lupus erythematosus in newborn infant . Arch Dermatol 1954;70:782-784. 2. Provost TT, Watson RM, Gammon WR: The neonatal lupus syndrome associated with U,RNP (nRNP) antibodies . N Engl J Med 1987;316:1135-1138.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1988

References