Abstract The purpose of this paper is to present the results of a clinical and laboratory study of sensation arising from stimulation of the duodenum. The chief of these sensations is nausea. Since nausea is a sensation, its presence must be identified with some objective or motor phenomenon before it can be studied by animal experimentation. Up to the present, no adequate studies dealing with the mechanism of nausea have been noted in the literature. I therefore believe that the present experiments open up a field for investigation, and hope that the data presented may stimulate further work on this important subject. METHODS The present study was made on a series of sixty ambulatory patients, the majority of whom complained of gastro-intestinal disturbances. In the number were many women, and prominent among their complaints were symptoms suggestive of circulatory instability. The Rehfuss tube was used for duodenal drainage. The stomach was References 1. Keeton, R. W., and Koch, F. C.: Am. J. Physiol. 37:481, 1915. 2. Luckhardt, A. B.; Keeton, R. W.; Koch, F. C., and La Mer, Victor: Am. J. Physiol. 50:527 ( (Jan.) ) 1920. 3. Keeton, R. W.; Koch, F. C., and Luckhardt, A. B.: Am. J. Physiol. 51:454; 469 ( (April) ) 1920. 4. Luckhardt, A. B.; Phillips, H. T., and Carlson, A. J.: Am. J. Physiol. 50:57 ( (Oct.) ) 1919. 5. Ivy, A. C.: Personal communication to the author. Data to be published soon. 6. Wheelon, H., and Thomas, E. J.: Am. J. Physiol. 59:72 ( (Feb.) ) 1922. 7. McClure, C. W.; Reynolds, L., and Schwartz, C. O.: On the Behavior of the Pyloric Sphincter in Normal Man , Arch. Int. Med. 26:410 ( (Oct.) ) 1920.Crossref 8. Brunemeier, E. H., and Carlson, A. J.: Am. J. Physiol. 36:191, 1915. 9. Ivy, A. C.: Am. J. Physiol. 46:340 ( (July) ) 1918. 10. Lehman, E. P., and Gibson, H. V.: Jejunal Fistula , J. A. M. A. 82:1918 ( (June 14) ) 1924.Crossref 11. Ivy, A. C., and McIlvain, G. B.: Am. J. Physiol. 67:124 ( (Dec.) ) 1923. 12. Wheelon, H., and Thomas, E. J.: J. Lab. & Clin. Med. 7:375 ( (April) ) 1922. 13. Carlson, A. J., and Litt, S.: Visceral Nervous System; Reflex Control of Pylorus , Arch. Int. Med. 33:281 ( (March) ) 1924. 14. Boas: Berl. klin. Wchnschr. 46:1101, 1909. 15. Alvarez, W. C.: Reverse Peristalsis , J. A. M. A. 69:2018 ( (Dec. 15) ) 1917. 16. Hesse, O.: Arch. f. d. ges. Physiol. 152:1, 1913. 17. Hatcher, R. A., and Weiss, Soma: J. Pharmacol. & Exper. Therap. 22:139 ( (Oct.) ) 1923 18. Seat of Emetic Action of Digitalis Bodies , Arch. Int. Med. 29:690 ( (May) ) 1922. 19. Alvarez, W. C.: Am. J. Physiol. 37:267, 1915 20. The Motor Functions of the Intestine from a New Point of View , J. A. M. A. 65:388 ( (July 31) ) 1915. 21. Alvarez, W. C. and Starkweather, E.: Am. J. Physiol. 46:186 ( (June) ) 1918. 22. Alvarez, W. C.: Physiological Rev. 4:352 ( (July) ) 1924. 23. Eggleston, C., and Hatcher, R. H.: J. Pharmacol. & Exper. Therap. 3:551, 1912. 24. Hatcher, R. A.: Physiological Rev. 4:479 ( (July) ) 1924. 25. Ewald, C. A.: Berl. klin. Wchnschr. 44:1416, 1907.
Archives of Internal Medicine – American Medical Association
Published: Jun 1, 1925