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NATURE OF VITAMIN B AND ITS COMPONENTS: WITH SPECIAL REFERENCE TO NERVE DEAFNESS

NATURE OF VITAMIN B AND ITS COMPONENTS: WITH SPECIAL REFERENCE TO NERVE DEAFNESS Abstract The accumulated total of human knowledge is incomprehensible. A few hundred years ago an aspiring scientist took all knowledge as his province, but the ever mounting mass of information necessarily led to specialization. The inevitable penalty of working in a restricted field is ignorance of progress outside one's special domain until some significant overlapping necessitates inquisitive excursions abroad. The possible relation between deficiency of vitamin B and at least some forms of nerve deafness, pointed out by Selfridge,1 and an attempt to alleviate a condition heretofore largely intractable entail certain questions which must be answered if therapeusis is to have some semblance of rationality. What is the chemical and biologic nature of this complex catalyst? Can a symptomatic picture be formulated so that the need for it can be diagnosed clinically ? Are there any laboratory procedures to aid investigators? What are the meanings of the new names and standards References 1. Selfridge, G.: Eighth Nerve High Tone Deafness from the Nutritional Standpoint , Ann. Otol., Rhin. & Laryng. 46:93-118 ( (March) ) 1937. 2. Rose, M. S.: The Foundations of Nutrition , New York, The Macmillan Company, 1938. 3. Addinall.19b 4. Booth, M., and Hansen, A. E.: Present Day Status of Vitamins: Review , Journal-Lancet 57:530-544 ( (Dec.) ) 1937. 5. Jones, D. B.: A Summary of Our Present Knowledge of Vitamins, United States Department of Agriculture , Bureau of Chemistry and Soils , (September) 1932. 6. Mendel, L. B., and others: The Vitamins: A Symposium on the Present Status of the Knowledge of Vitamins , Chicago, American Medical Association, 1932. 7. Peters, R. A.: Vitamin B Complex , Brit. M. J. 2:903-905 ( (Nov. 7) ) 1936. 8. Lepkovsky, S.; Jukes, T. H., and Krause, M. E.: Multiple Nature of Third Factor of Vitamin B Complex , J. Biol. Chem. 115:557-566 ( (Sept.) ) 1936. 9. Williams, R. R.: The Chemistry of Thiamin (Vitamin B1) , J. A. M. A. 110:727-732 ( (March 5) ) 1938 10. Riboflavin, the Accepted Name for Vitamin B2, report of the Council on Pharmacy and Chemistry , Williams J. A. M. A. 108:1340-1341 ( (April 17) ) 1937. 11. Peters, R. A.: Biochemical Lesion in Vitamin B1 Deficiency , Lancet 1:1161-1165 ( (May 23) ) 1936. 12. Gutman, J.: Modern Views on Vitamins and Treatment of Nutritional Disorders , M. Rec. 146:129 ( (Aug. 4) ) 13. 228 (Sept. 1) 1937. 14. Enler, cited by Rose.2 15. Wilder, R. M., and Wilbur, D. L.: Diseases of Metabolism and Nutrition: Review of Certain Recent Contributions , Arch. Int. Med. 59:512-555 ( (March) ) 1937. 16. Elvehjem, C. A.: Present Status of Vitamin B Complex , Am. J. Pub. Health 25:1334-1339 ( (Dec.) ) 1935. 17. Schultz, H. W., and Mattill, H. A.: Studies on Vitamin B Complex , J. Biol. Chem. 122:183-198 ( (Dec.) ) 1937. 18. Harris, L. J., and Leong, P. C.: Vitamins in Human Nutrition: Excretion of Vitamin B1 in Human Urine and Its Dependence on Dietary Intake , Lancet 1:886-894 ( (April 18) ) 1936. 19. Elsom, K. O.: Practical Aspects of Deficiency , M. Clin. North America 21:1229-1244 ( (July) ) 1937. 20. Footnote deleted. 21. Mackie, T. T.: Ulcerative Colitis: Factor of Deficiency States , J. A. M. A. 104:175-178 ( (Jan. 19) ) 1935. 22. Narat, J. K., and Losf, J. A.: Effects of Vitamin Bi Concentrate (on Peristalsis and Blood Pressure) , Arch. Int. Med. 60:449-453 ( (Sept.) ) 1937. 23. Booth and Hansen.4 24. Addinall, C. R.: The Story of Vitamin B1 , Rahway, N. J., Merck & Co., Inc., 1937. 25. Wilder and Wilbur.11 26. Booth and Hansen.4 27. Wilder and Wilbur.11 28. Koepcke, G. M.: Vitamins and Infections of Eye, Nose, Throat and Sinuses , Journal-Lancet 57:460-462 ( (Oct.) ) 1937. 29. Stevenson, D.: Vitamin B1 in the Treatment of Neuritis , Practitioner 140:301-306 ( (March) ) 1938. 30. Selfridge, G.: Chronic Progressive Deafness , Mid-Winter Clinical Course of the Research Study Club, Los Angeles, 1938, privately printed. 31. Rose.2 32. Meurlin, J. R.: Vitamins and Hormones , J. Am. Dietet. A. 14:397-411 ( (June) -July) 1938. 33. Cody, C. C., Jr.: The Relation of Vitamins A, D, B and G to Otolaryngology , Tr. Am. Laryng., Rhin. & Otol. Soc. 38:289-305, 1932. 34. Shambaugh, G. E., Jr.: Chronic Progressive Deafness Including Otosclerosis and Diseases of the Inner Ear , Arch. Otolaryng. 26:583-605 ( (Nov.) ) 1937. 35. Kagawa, S., and Naito, H.: Die experimentelle B1-Avitaminose beim Menschen , Jap. J. M. Sc., VIII, Int. Med., Pediat. & Psychiat. 4:128*-129* ( (Feb.) ) 1936. 36. Harris, L. J.: A Programme for Nutrition Surveys , Lancet 1:966-968 ( (April 25) ) 1936. 37. Roscoe, M. H.: B-Vitamins in Human Urine , Biochem. J. 30:1053-1065 ( (June) ) 1936. 38. Helmer, O. M.: Vitamin B1 and B2 Content of Human Urine , Proc. Soc. Exper. Biol. & Med. 32:1187-1188 ( (April) ) 1935. 39. Booth and Hansen.4 40. Johnson, R. E.: Isolation of Pyruvic Acid from Blood of Vitamin B1-Deficient Pigeons , Biochem. J. 30:31-32 ( (Jan.) ) 1936. 41. Meiklejohn, A. P.: Estimation of Vitamin B1 in Blood by a Modification of Schopfer's Test , Biochem. J. 31:1441-1451 ( (Sept.) ) 1937. 42. Prebluda, H. J., and McCollum, E. V.: Chemical Reagent for Detection and Estimation of Vitamin B1 , Science 84:488 ( (Nov. 27) ) 1936. 43. Naiman, B.: A Reagent for Vitamin B1 , Science 85:290 ( (March 19) ) 1937. 44. Westenbrink, H. G. K., and Goudsmit, J.: The Determination of Aneurin (Vitamin B1) in Urine by the Thiochrome Reaction , Rec. d. trav. chim. d. Pays-Bas 56:7, 1937. 45. Clark, G. W.: Personal communication to the author. 46. Hunsberger, A., Jr.: Personal communication to the author. 47. Weigand, C. G.: Personal communication to the author. 48. Elvehjem.12 49. Cowgill, G. R.: The Vitamin B Requirements of Man , New Haven, Conn., Yale University Press, 1934. 50. Borsook, cited by Smith.43b 51. Elsom.15 52. Cody.26 53. Elsom.15 54. Smith, H. A.: Personal communication to the author. 55. Selfridge, G.: Chronic Progressive Deafness from a Nutritional Standpoint: Preliminary Report , Ann. Otol., Rhin. & Laryng. 46:875-894 ( (Dec.) ) 1937. 56. National Institute of Nutrition: Personal communication to the author. 57. Wilder, R. M., and Wilbur, D. L.: Diseases of Metabolism and Nutrition: Review of Certain Recent Contributions , Arch. Int. Med. 57:422-471 ( (Feb.) ) 1936. 58. Copping, A. M., and Roscoe, M. H.: The Water-Soluble B-Vitamins in Yeast, Flour and Bread , Biochem. J. 31:1879-1902 ( (Oct.) ) 1937. 59. Daniel, E. P., and Munsell, H. E.: Vitamin Content of Foods: A Summary of the Chemistry of Vitamins, Units of Measurement, Quantitative Aspects in Human Nutrition and Occurrence in Foods, Miscellaneous Publication 275, United States Department of Agriculture, June 1937. 60. H. J. Heinz Company has furnished nutritional data and charts corroborating this statement. 61. Siemers, G. F.: Personal communication to the author. 62. Shakman, J. G.: Personal communication to the author. 63. Hanning, F.: Vitamin B in Canned, Strained Vegetables: Further Studies , J. Am. Dietet. A. 12:231-236 ( (Sept.) ) 1936. 64. Rose, M. S., and Phipard, E. H. F.: Vitamin B and G Values of Peas and Lima Beans Under Various Conditions , J. Nutrition 14:55-67 ( (July) ) 1937. 65. Copping and Roscoe.46 66. Daniel and Munsell.47 67. Rose.2 68. Garnett, W. P.: Personal communication to the author. 69. Smith.43b 70. Rose.2 71. Rose and Phipard.52 72. Itter, S.: Personal communication to the author. 73. How We Get Our Vitamins, Special Circular, Extension Service, Department of Agriculture, University of Wisconsin, June 1936. 74. Jones, D. B.: Personal communication to the author. 75. Lankenau, J. C.: Personal communication to the author. 76. Harding, E. R.: Personal communication to the author. 77. Libby, McNeil & Libby. 78. Selfridge, G.: The Eighth Nerve in Relation to Thiamin Chloride and Nicotinic Acid: A Comparative Study , Ann. Otol., Rhin. & Laryng. 48:419-432 ( (June) ) 1939. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

NATURE OF VITAMIN B AND ITS COMPONENTS: WITH SPECIAL REFERENCE TO NERVE DEAFNESS

Archives of Otolaryngology , Volume 31 (1) – Jan 1, 1940

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American Medical Association
Copyright
Copyright © 1940 American Medical Association. All Rights Reserved.
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0003-9977
DOI
10.1001/archotol.1940.00660010075009
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Abstract

Abstract The accumulated total of human knowledge is incomprehensible. A few hundred years ago an aspiring scientist took all knowledge as his province, but the ever mounting mass of information necessarily led to specialization. The inevitable penalty of working in a restricted field is ignorance of progress outside one's special domain until some significant overlapping necessitates inquisitive excursions abroad. The possible relation between deficiency of vitamin B and at least some forms of nerve deafness, pointed out by Selfridge,1 and an attempt to alleviate a condition heretofore largely intractable entail certain questions which must be answered if therapeusis is to have some semblance of rationality. What is the chemical and biologic nature of this complex catalyst? Can a symptomatic picture be formulated so that the need for it can be diagnosed clinically ? Are there any laboratory procedures to aid investigators? What are the meanings of the new names and standards References 1. Selfridge, G.: Eighth Nerve High Tone Deafness from the Nutritional Standpoint , Ann. Otol., Rhin. & Laryng. 46:93-118 ( (March) ) 1937. 2. Rose, M. S.: The Foundations of Nutrition , New York, The Macmillan Company, 1938. 3. Addinall.19b 4. Booth, M., and Hansen, A. E.: Present Day Status of Vitamins: Review , Journal-Lancet 57:530-544 ( (Dec.) ) 1937. 5. Jones, D. B.: A Summary of Our Present Knowledge of Vitamins, United States Department of Agriculture , Bureau of Chemistry and Soils , (September) 1932. 6. Mendel, L. B., and others: The Vitamins: A Symposium on the Present Status of the Knowledge of Vitamins , Chicago, American Medical Association, 1932. 7. Peters, R. A.: Vitamin B Complex , Brit. M. J. 2:903-905 ( (Nov. 7) ) 1936. 8. Lepkovsky, S.; Jukes, T. H., and Krause, M. E.: Multiple Nature of Third Factor of Vitamin B Complex , J. Biol. Chem. 115:557-566 ( (Sept.) ) 1936. 9. Williams, R. R.: The Chemistry of Thiamin (Vitamin B1) , J. A. M. A. 110:727-732 ( (March 5) ) 1938 10. Riboflavin, the Accepted Name for Vitamin B2, report of the Council on Pharmacy and Chemistry , Williams J. A. M. A. 108:1340-1341 ( (April 17) ) 1937. 11. Peters, R. A.: Biochemical Lesion in Vitamin B1 Deficiency , Lancet 1:1161-1165 ( (May 23) ) 1936. 12. Gutman, J.: Modern Views on Vitamins and Treatment of Nutritional Disorders , M. Rec. 146:129 ( (Aug. 4) ) 13. 228 (Sept. 1) 1937. 14. Enler, cited by Rose.2 15. Wilder, R. M., and Wilbur, D. L.: Diseases of Metabolism and Nutrition: Review of Certain Recent Contributions , Arch. Int. Med. 59:512-555 ( (March) ) 1937. 16. Elvehjem, C. A.: Present Status of Vitamin B Complex , Am. J. Pub. Health 25:1334-1339 ( (Dec.) ) 1935. 17. Schultz, H. W., and Mattill, H. A.: Studies on Vitamin B Complex , J. Biol. Chem. 122:183-198 ( (Dec.) ) 1937. 18. Harris, L. J., and Leong, P. C.: Vitamins in Human Nutrition: Excretion of Vitamin B1 in Human Urine and Its Dependence on Dietary Intake , Lancet 1:886-894 ( (April 18) ) 1936. 19. Elsom, K. O.: Practical Aspects of Deficiency , M. Clin. North America 21:1229-1244 ( (July) ) 1937. 20. Footnote deleted. 21. Mackie, T. T.: Ulcerative Colitis: Factor of Deficiency States , J. A. M. A. 104:175-178 ( (Jan. 19) ) 1935. 22. Narat, J. K., and Losf, J. A.: Effects of Vitamin Bi Concentrate (on Peristalsis and Blood Pressure) , Arch. Int. Med. 60:449-453 ( (Sept.) ) 1937. 23. Booth and Hansen.4 24. Addinall, C. R.: The Story of Vitamin B1 , Rahway, N. J., Merck & Co., Inc., 1937. 25. Wilder and Wilbur.11 26. Booth and Hansen.4 27. Wilder and Wilbur.11 28. Koepcke, G. M.: Vitamins and Infections of Eye, Nose, Throat and Sinuses , Journal-Lancet 57:460-462 ( (Oct.) ) 1937. 29. Stevenson, D.: Vitamin B1 in the Treatment of Neuritis , Practitioner 140:301-306 ( (March) ) 1938. 30. Selfridge, G.: Chronic Progressive Deafness , Mid-Winter Clinical Course of the Research Study Club, Los Angeles, 1938, privately printed. 31. Rose.2 32. Meurlin, J. R.: Vitamins and Hormones , J. Am. Dietet. A. 14:397-411 ( (June) -July) 1938. 33. Cody, C. C., Jr.: The Relation of Vitamins A, D, B and G to Otolaryngology , Tr. Am. Laryng., Rhin. & Otol. Soc. 38:289-305, 1932. 34. Shambaugh, G. E., Jr.: Chronic Progressive Deafness Including Otosclerosis and Diseases of the Inner Ear , Arch. Otolaryng. 26:583-605 ( (Nov.) ) 1937. 35. Kagawa, S., and Naito, H.: Die experimentelle B1-Avitaminose beim Menschen , Jap. J. M. Sc., VIII, Int. Med., Pediat. & Psychiat. 4:128*-129* ( (Feb.) ) 1936. 36. Harris, L. J.: A Programme for Nutrition Surveys , Lancet 1:966-968 ( (April 25) ) 1936. 37. Roscoe, M. H.: B-Vitamins in Human Urine , Biochem. J. 30:1053-1065 ( (June) ) 1936. 38. Helmer, O. M.: Vitamin B1 and B2 Content of Human Urine , Proc. Soc. Exper. Biol. & Med. 32:1187-1188 ( (April) ) 1935. 39. Booth and Hansen.4 40. Johnson, R. E.: Isolation of Pyruvic Acid from Blood of Vitamin B1-Deficient Pigeons , Biochem. J. 30:31-32 ( (Jan.) ) 1936. 41. Meiklejohn, A. P.: Estimation of Vitamin B1 in Blood by a Modification of Schopfer's Test , Biochem. J. 31:1441-1451 ( (Sept.) ) 1937. 42. Prebluda, H. J., and McCollum, E. V.: Chemical Reagent for Detection and Estimation of Vitamin B1 , Science 84:488 ( (Nov. 27) ) 1936. 43. Naiman, B.: A Reagent for Vitamin B1 , Science 85:290 ( (March 19) ) 1937. 44. Westenbrink, H. G. K., and Goudsmit, J.: The Determination of Aneurin (Vitamin B1) in Urine by the Thiochrome Reaction , Rec. d. trav. chim. d. Pays-Bas 56:7, 1937. 45. Clark, G. W.: Personal communication to the author. 46. Hunsberger, A., Jr.: Personal communication to the author. 47. Weigand, C. G.: Personal communication to the author. 48. Elvehjem.12 49. Cowgill, G. R.: The Vitamin B Requirements of Man , New Haven, Conn., Yale University Press, 1934. 50. Borsook, cited by Smith.43b 51. Elsom.15 52. Cody.26 53. Elsom.15 54. Smith, H. A.: Personal communication to the author. 55. Selfridge, G.: Chronic Progressive Deafness from a Nutritional Standpoint: Preliminary Report , Ann. Otol., Rhin. & Laryng. 46:875-894 ( (Dec.) ) 1937. 56. National Institute of Nutrition: Personal communication to the author. 57. Wilder, R. M., and Wilbur, D. L.: Diseases of Metabolism and Nutrition: Review of Certain Recent Contributions , Arch. Int. Med. 57:422-471 ( (Feb.) ) 1936. 58. Copping, A. M., and Roscoe, M. H.: The Water-Soluble B-Vitamins in Yeast, Flour and Bread , Biochem. J. 31:1879-1902 ( (Oct.) ) 1937. 59. Daniel, E. P., and Munsell, H. E.: Vitamin Content of Foods: A Summary of the Chemistry of Vitamins, Units of Measurement, Quantitative Aspects in Human Nutrition and Occurrence in Foods, Miscellaneous Publication 275, United States Department of Agriculture, June 1937. 60. H. J. Heinz Company has furnished nutritional data and charts corroborating this statement. 61. Siemers, G. F.: Personal communication to the author. 62. Shakman, J. G.: Personal communication to the author. 63. Hanning, F.: Vitamin B in Canned, Strained Vegetables: Further Studies , J. Am. Dietet. A. 12:231-236 ( (Sept.) ) 1936. 64. Rose, M. S., and Phipard, E. H. F.: Vitamin B and G Values of Peas and Lima Beans Under Various Conditions , J. Nutrition 14:55-67 ( (July) ) 1937. 65. Copping and Roscoe.46 66. Daniel and Munsell.47 67. Rose.2 68. Garnett, W. P.: Personal communication to the author. 69. Smith.43b 70. Rose.2 71. Rose and Phipard.52 72. Itter, S.: Personal communication to the author. 73. How We Get Our Vitamins, Special Circular, Extension Service, Department of Agriculture, University of Wisconsin, June 1936. 74. Jones, D. B.: Personal communication to the author. 75. Lankenau, J. C.: Personal communication to the author. 76. Harding, E. R.: Personal communication to the author. 77. Libby, McNeil & Libby. 78. Selfridge, G.: The Eighth Nerve in Relation to Thiamin Chloride and Nicotinic Acid: A Comparative Study , Ann. Otol., Rhin. & Laryng. 48:419-432 ( (June) ) 1939.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Jan 1, 1940

References