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Nature of Certain Osseous Lesions in Tuberous Sclerosis

Nature of Certain Osseous Lesions in Tuberous Sclerosis Abstract It has been well established that characteristic roentgenographic signs may play a significant part in the diagnosis of the syndrome known as tuberous sclerosis. Recently, Holt and I1 demonstrated that 66% of our patients had definite roentgenographic changes in the phalanges of the hands and feet. A similar incidence has since been found by Berland.2 We pointed out that the histologic nature of these lesions had not been demonstrated, but speculated that "the bone cysts are not cysts at all in the true sense of the word. They probably represent areas of nonspecific fibrous replacement similar to that found in the transient cortical defects of growing tubular bones and certain cystic forms of neurofibromatosis of bone." This report is concerned with the histologic structure of the lesions found in the terminal phalanges of the hands of a patient suffering from tuberous sclerosis. REPORT OF A CASE J. O., References 1. Holt, J. F., and Dickerson, W. W.: The Osseous Lesions of Tuberous Sclerosis , Radiology 58:1-8 ( (Jan.) ) 1952.Crossref 2. Berland, H. I.: Roentgenological Findings in Tuberous Sclerosis , A. M. A. Arch. Neurol. & Psychiat. 69:669-683 ( (June) ) 1953. 3. Brooks, B., and Lehman, E. P.: Bone Changes in Recklinghausen's Neurofibromatosis , Surg., Gynec. & Obst. 38:587-595 ( (May) ) 1924. 4. Yakovlev, P. I., and Corwin, W.: A Roentgenographic Sign in Cases of Tuberous Sclerosis of Brain (Multiple "Brain Stones") , Arch. Neurol. & Psychiat. 42:1030-1037 ( (Dec.) ) 1939. 5. Holt, J. F., and Wright, E. M.: Radiologic Features of Neurofibromatosis , Radiology 51:647-664 ( (Nov.) ) 1948. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Nature of Certain Osseous Lesions in Tuberous Sclerosis

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330110041004
Publisher site
See Article on Publisher Site

Abstract

Abstract It has been well established that characteristic roentgenographic signs may play a significant part in the diagnosis of the syndrome known as tuberous sclerosis. Recently, Holt and I1 demonstrated that 66% of our patients had definite roentgenographic changes in the phalanges of the hands and feet. A similar incidence has since been found by Berland.2 We pointed out that the histologic nature of these lesions had not been demonstrated, but speculated that "the bone cysts are not cysts at all in the true sense of the word. They probably represent areas of nonspecific fibrous replacement similar to that found in the transient cortical defects of growing tubular bones and certain cystic forms of neurofibromatosis of bone." This report is concerned with the histologic structure of the lesions found in the terminal phalanges of the hands of a patient suffering from tuberous sclerosis. REPORT OF A CASE J. O., References 1. Holt, J. F., and Dickerson, W. W.: The Osseous Lesions of Tuberous Sclerosis , Radiology 58:1-8 ( (Jan.) ) 1952.Crossref 2. Berland, H. I.: Roentgenological Findings in Tuberous Sclerosis , A. M. A. Arch. Neurol. & Psychiat. 69:669-683 ( (June) ) 1953. 3. Brooks, B., and Lehman, E. P.: Bone Changes in Recklinghausen's Neurofibromatosis , Surg., Gynec. & Obst. 38:587-595 ( (May) ) 1924. 4. Yakovlev, P. I., and Corwin, W.: A Roentgenographic Sign in Cases of Tuberous Sclerosis of Brain (Multiple "Brain Stones") , Arch. Neurol. & Psychiat. 42:1030-1037 ( (Dec.) ) 1939. 5. Holt, J. F., and Wright, E. M.: Radiologic Features of Neurofibromatosis , Radiology 51:647-664 ( (Nov.) ) 1948.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: May 1, 1955

References