Abstract A statistical study of 240 patients with nevus of Ota was carried out. The onset was before 1 year of age in 119 and after the age of 2 in 121. Onset between the ages of 1 and 11 years is distinctly rare. In type 3, 77% of the cases began before 1 year of age. Color is influenced by fatigue, menstruation, insomnia, and weather. The association of ocular and buccal melanosis and of Mongolian spots and blue nevus was discussed. Among 207 families, there were two familial incidences and 15 patients whose parents were related, but heredity was not suggested. No malignant change was observed. Clinical features in childhood, in adolescence, and in old age were described. Spontaneous regression did not occur. The clinical course in childhood was followed, and subtle changes of extent, tone, and intensity of color were observed. It was concluded that before 1 year of age pigmentation increases, and after the age of 2 it may show a regression. References 1. Tanino, H.: Uber eine in Japan häufig vorkommende Nävusform: Naevus fusco-caeruleus ophthalmo-maxillaris Ota: I. Mitteilung , Jap J Derm 46:107, 1939. 2. Mishima, Y., and Mevorah, B.: Nevus Ota and Nevus Ito in American Negroes J Invest Derm 36:133, 1961. 3. Hidano, A.; Nomoto, K.; and Mishima Y.: Pigmentation des muqueuses dans le naevus d'Ota , Bull Soc Franc Derm Syph 64:287, 1957. 4. Yokozeki, M., and Kitagawa, K.: Nevus of Ota on the Auricle , Rinsho Hifuhinyokika , vol 18 (No. (11) ), 1964. 5. Carleton, A., and Biggs, R.: Diffuse Mesodermal Pigmentation With Cranial Abnormality , Brit J Derm 60:10, 1948.Crossref 6. Hidano, A.; Kajima, H.; and Endo, Y.: Bilateral Nevus Ota Associated With Nevus Ito , Arch Derm 91:357, 1965.Crossref 7. Yoshida, K.: Nevus fusco-caeruleus ophthalmomaxillaris Ota , Tohoku J Exp Med 55 ( (suppl 1) ):34, 1952.Crossref 8. Kojima, K., et al: A Melanoma of the Optic Chiasm Occurred in a Case of Ota's Nevus and Melanosis Bulbi , Rinsho Ganka , 13:392, 1959. 9. Kobori, T., et al: A Case of Bilateral Nevus Ota Associated With Melanoma of Fundus , Jap J Derm 73:307, 1963. 10. Dorsey, C.S., and Montgomery, H.: Blue Nevus and Its Distinction From Mongolian Spots and the Nevus of Ota , J Invest Derm 22:225, 1954.Crossref 11. Tôyama, I., and Ohmori, S.: On Hereditary Skin Diseases in Japan: I. Observations Upon the Summary of Literatures Belonging to Nevi and Nevoid Diseases , Jap J Derm 59:37, 1949. 12. Watanabe, M.: Familial Occurrence of Nevus Ota , Jap J Derm 62:283, 1952.
Archives of Dermatology – American Medical Association
Published: Feb 1, 1967