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Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2 Antibodies and Tonsillar Carcinoma

Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2... OBSERVATION Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2 Antibodies and Tonsillar Carcinoma Chris Adams, MS; Andrew McKeon, MD, MRCPI; Michael H. Silber, MB, ChB; Rajeev Kumar, MD Objective: To describe a patient with diencephalic and and symptomatic treatment for parkinsonism and sleep mesencephalic presentation of a Ma1 and Ma2 antibody– disorders. associated paraneoplastic neurological disorder. Main Outcome Measures: Polysomnography, mul- Design: Case report. tiple sleep latency test, and neurological examination. Setting: The Colorado Neurological Institute Move- Results: The cancer was detected at a limited stage and ment Disorders Center in Englewood, Colorado, and the treatable. After oncological therapy and immuno- Mayo Clinic in Rochester, Minnesota. therapy, symptoms stabilized. Treatment with mo- dafinil improved daytime somnolence. Patient: A 55-year-old man with a paraneoplastic neu- rological disorder characterized by rapid eye movement Conclusions: Rapid onset and progression of multifocal sleep behavior disorder, narcolepsy, and a progressive su- deficits may be a clue to paraneoplastic etiology. Early treat- pranuclear palsy–like syndrome in the setting of tonsil- ment of a limited stage cancer (with or without immuno- lar carcinoma. therapy) may possibly slow progression of neurological symptoms. Symptomatic treatment may be beneficial. Intervention: Immunotherapy for paraneoplastic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2 Antibodies and Tonsillar Carcinoma

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2011.56
pmid
21482933
Publisher site
See Article on Publisher Site

Abstract

OBSERVATION Narcolepsy, REM Sleep Behavior Disorder, and Supranuclear Gaze Palsy Associated With Ma1 and Ma2 Antibodies and Tonsillar Carcinoma Chris Adams, MS; Andrew McKeon, MD, MRCPI; Michael H. Silber, MB, ChB; Rajeev Kumar, MD Objective: To describe a patient with diencephalic and and symptomatic treatment for parkinsonism and sleep mesencephalic presentation of a Ma1 and Ma2 antibody– disorders. associated paraneoplastic neurological disorder. Main Outcome Measures: Polysomnography, mul- Design: Case report. tiple sleep latency test, and neurological examination. Setting: The Colorado Neurological Institute Move- Results: The cancer was detected at a limited stage and ment Disorders Center in Englewood, Colorado, and the treatable. After oncological therapy and immuno- Mayo Clinic in Rochester, Minnesota. therapy, symptoms stabilized. Treatment with mo- dafinil improved daytime somnolence. Patient: A 55-year-old man with a paraneoplastic neu- rological disorder characterized by rapid eye movement Conclusions: Rapid onset and progression of multifocal sleep behavior disorder, narcolepsy, and a progressive su- deficits may be a clue to paraneoplastic etiology. Early treat- pranuclear palsy–like syndrome in the setting of tonsil- ment of a limited stage cancer (with or without immuno- lar carcinoma. therapy) may possibly slow progression of neurological symptoms. Symptomatic treatment may be beneficial. Intervention: Immunotherapy for paraneoplastic

Journal

JAMA NeurologyAmerican Medical Association

Published: Apr 1, 2011

References