Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

NARCOLEPSY: II. Theory of Pathogenesis of the Narcolepsy-Cataplexy Syndrome

NARCOLEPSY: II. Theory of Pathogenesis of the Narcolepsy-Cataplexy Syndrome Abstract IN a careful review of the literature on narcolepsy, Wilson1 found that authors had classified narcolepsy according to the following etiologic factors: (1) trauma; (2) toxi-infectious states, such as encephalitis; (3) epilepsy; (4) endocrine disturbances, such as obesity; (5) psychopathologic disturbances; (6) local lesions (vascular lesions, tumor), and (7) cryptogenic conditions. He criticized these categories because they were not mutually exclusive, because presumably "predisposing" factors may be only accompaniments and because the influence of trauma can be overrated. He argued, further, that autopsy had not been performed in any case to ascertain the existence of such groups and that pathologic information at one's disposal was derived from cases of prolonged or continuous sleep and not from cases of the true narcolepsy-cataplexy syndrome. Therefore, although many researches tended to point to the floor, sides and posterior end of the third ventricle as a part of the neuraxis the mechanisms of References 1. Wilson, S. A. K.: Neurology , edited by A. N. Bruce, London, Edward Arnold & Co., 1940. 2. Wilson, S. A. K.: The Narcolepsies , Brain 51:63-109, 1928Crossref 3. Modern Problems in Neurology , London, Edward Arnold & Co., 1928. 4. Pavlov, I. P.: Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex , translated and edited by G. V. Anrep, London, Oxford University Press, 1927. 5. Cohn, R., and Cruvant, B. A.: Relation of Narcolepsy to the Epilepsies: A Clinical-Electroencephalographic Study , Arch. Neurol. & Psychiat. 51:163 ( (Feb.) ) 1944. 6. Pavlov, I. P.: Lectures on Conditioned Reflexes , translated by W. H. Gantt, New York, International Publishers, 1941, vol. 2. 7. Pavlov,5 p. 14. 8. Pavlov,5 p. 51. 9. Fabing, H. D.: Narcolepsy: I. Combat Experience of a Soldier with Narcolepsy , Arch. Neurol. & Psychiat. 54:367-371 ( (Nov.-Dec.) ) 1945. 10. Pavlov,5 p. 174. 11. Pavlov,5 p. 14. 12. Sherrington, C. S.: Note on the Knee-Jerk and the Correlation of Action of Antagonistic Muscles , Proc. Roy. Soc., London 52:556-564, 1893. 13. Dusser de Barenne, J. G., and McCulloch, W. S.: Factors for Facilitation and Extinction in the Central Nervous System , J. Neurophysiol. 2:319-355, 1939. 14. Fulton, J. F.: Physiology of the Nervous System , ed. 2, London, Oxford University Press, 1943. 15. Walshe, F. M. R.: On the Mode of Representation of Movements in the Motor Cortex, with Special Reference to "Convulsions Beginning Unilaterally" (Jackson) , Brain 66:104-139, 1943. 16. Pavlov,5 p. 164. 17. Gasser, H. F.: The Control of Excitation in the Nervous System, in Harvey Lectures, 1936-1937 , Baltimore, Williams & Wilkins Company, 1937, vol. 32, pp. 169-193 18. Fulton,13 p. 85. 19. Redlich, E.: Epilegomena zur Narkolepsiefrage , Ztschr. f. d. ges. Neurol. u. Psychiat. 136:128-173, 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

NARCOLEPSY: II. Theory of Pathogenesis of the Narcolepsy-Cataplexy Syndrome

Archives of Neurology & Psychiatry , Volume 55 (4) – Apr 1, 1946

Loading next page...
 
/lp/american-medical-association/narcolepsy-ii-theory-of-pathogenesis-of-the-narcolepsy-cataplexy-m7Wh0mM8Di
Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1946.02300150057004
Publisher site
See Article on Publisher Site

Abstract

Abstract IN a careful review of the literature on narcolepsy, Wilson1 found that authors had classified narcolepsy according to the following etiologic factors: (1) trauma; (2) toxi-infectious states, such as encephalitis; (3) epilepsy; (4) endocrine disturbances, such as obesity; (5) psychopathologic disturbances; (6) local lesions (vascular lesions, tumor), and (7) cryptogenic conditions. He criticized these categories because they were not mutually exclusive, because presumably "predisposing" factors may be only accompaniments and because the influence of trauma can be overrated. He argued, further, that autopsy had not been performed in any case to ascertain the existence of such groups and that pathologic information at one's disposal was derived from cases of prolonged or continuous sleep and not from cases of the true narcolepsy-cataplexy syndrome. Therefore, although many researches tended to point to the floor, sides and posterior end of the third ventricle as a part of the neuraxis the mechanisms of References 1. Wilson, S. A. K.: Neurology , edited by A. N. Bruce, London, Edward Arnold & Co., 1940. 2. Wilson, S. A. K.: The Narcolepsies , Brain 51:63-109, 1928Crossref 3. Modern Problems in Neurology , London, Edward Arnold & Co., 1928. 4. Pavlov, I. P.: Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex , translated and edited by G. V. Anrep, London, Oxford University Press, 1927. 5. Cohn, R., and Cruvant, B. A.: Relation of Narcolepsy to the Epilepsies: A Clinical-Electroencephalographic Study , Arch. Neurol. & Psychiat. 51:163 ( (Feb.) ) 1944. 6. Pavlov, I. P.: Lectures on Conditioned Reflexes , translated by W. H. Gantt, New York, International Publishers, 1941, vol. 2. 7. Pavlov,5 p. 14. 8. Pavlov,5 p. 51. 9. Fabing, H. D.: Narcolepsy: I. Combat Experience of a Soldier with Narcolepsy , Arch. Neurol. & Psychiat. 54:367-371 ( (Nov.-Dec.) ) 1945. 10. Pavlov,5 p. 174. 11. Pavlov,5 p. 14. 12. Sherrington, C. S.: Note on the Knee-Jerk and the Correlation of Action of Antagonistic Muscles , Proc. Roy. Soc., London 52:556-564, 1893. 13. Dusser de Barenne, J. G., and McCulloch, W. S.: Factors for Facilitation and Extinction in the Central Nervous System , J. Neurophysiol. 2:319-355, 1939. 14. Fulton, J. F.: Physiology of the Nervous System , ed. 2, London, Oxford University Press, 1943. 15. Walshe, F. M. R.: On the Mode of Representation of Movements in the Motor Cortex, with Special Reference to "Convulsions Beginning Unilaterally" (Jackson) , Brain 66:104-139, 1943. 16. Pavlov,5 p. 164. 17. Gasser, H. F.: The Control of Excitation in the Nervous System, in Harvey Lectures, 1936-1937 , Baltimore, Williams & Wilkins Company, 1937, vol. 32, pp. 169-193 18. Fulton,13 p. 85. 19. Redlich, E.: Epilegomena zur Narkolepsiefrage , Ztschr. f. d. ges. Neurol. u. Psychiat. 136:128-173, 1932.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Apr 1, 1946

References