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Naproxen's Interaction With Aspirin May Affect Its Cardioprotective Effect

Naproxen's Interaction With Aspirin May Affect Its Cardioprotective Effect Dr Dalen's1 reply to the comments of Mukherjee and colleagues2 suggests the possibility of a clinical trial to attempt to answer the question if naproxen decreases the risk of myocardial infarction or if cyclooxygenase inhibitors increase the risk. One of the proposed treatment arms would include patients receiving both naproxen and aspirin. To be credible, such a project would require a preliminary evaluation to see if there is any modulation of the cardioprotective effect of naproxen when it is used in conjunction with aspirin. A previously published study with ibuprofen (another propionic acid derivative) showed a blockage of aspirin's effect on inhibition of thromboxane B2 formation as well as platelet aggregation.3 References 1. Dalen JE In reply [letter]. Arch Intern Med. 2002;1622638- 2639Google Scholar 2. Mukherjee DNissen SETopol EJ Lack of cardioprotective effect of naproxen [letter]. N Engl J Med. 2002;1622637Google Scholar 3. Catella-Lawson FReilly MPKapoor SC et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;3451809- 1817Google ScholarCrossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Naproxen's Interaction With Aspirin May Affect Its Cardioprotective Effect

Archives of Internal Medicine , Volume 163 (11) – Jun 9, 2003

Naproxen's Interaction With Aspirin May Affect Its Cardioprotective Effect

Abstract

Dr Dalen's1 reply to the comments of Mukherjee and colleagues2 suggests the possibility of a clinical trial to attempt to answer the question if naproxen decreases the risk of myocardial infarction or if cyclooxygenase inhibitors increase the risk. One of the proposed treatment arms would include patients receiving both naproxen and aspirin. To be credible, such a project would require a preliminary evaluation to see if there is any modulation of the cardioprotective effect of naproxen...
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Publisher
American Medical Association
Copyright
Copyright © 2003 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.163.11.1374-a
Publisher site
See Article on Publisher Site

Abstract

Dr Dalen's1 reply to the comments of Mukherjee and colleagues2 suggests the possibility of a clinical trial to attempt to answer the question if naproxen decreases the risk of myocardial infarction or if cyclooxygenase inhibitors increase the risk. One of the proposed treatment arms would include patients receiving both naproxen and aspirin. To be credible, such a project would require a preliminary evaluation to see if there is any modulation of the cardioprotective effect of naproxen when it is used in conjunction with aspirin. A previously published study with ibuprofen (another propionic acid derivative) showed a blockage of aspirin's effect on inhibition of thromboxane B2 formation as well as platelet aggregation.3 References 1. Dalen JE In reply [letter]. Arch Intern Med. 2002;1622638- 2639Google Scholar 2. Mukherjee DNissen SETopol EJ Lack of cardioprotective effect of naproxen [letter]. N Engl J Med. 2002;1622637Google Scholar 3. Catella-Lawson FReilly MPKapoor SC et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;3451809- 1817Google ScholarCrossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jun 9, 2003

Keywords: aspirin

References