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N-methyl-D-aspartate Receptor Autoimmune Encephalitis Presenting With Opsoclonus-Myoclonus

N-methyl-D-aspartate Receptor Autoimmune Encephalitis Presenting With Opsoclonus-Myoclonus OBSERVATION N-methyl-D-aspartate Receptor Autoimmune Encephalitis Presenting With Opsoclonus-Myoclonus Treatment Response to Plasmapheresis Jonathan H. Smith, MD; Radhika Dhamija, MBBS; Brian D. Moseley, MD; Paola Sandroni, MD, PhD; Claudia F. Lucchinetti, MD; Vanda A. Lennon, MD, PhD; Orhun H. Kantarci, MD Objectives: To report the clinical, laboratory, and ra- evated IgG index, and positive oligoclonal banding. Au- diographic features and the response to plasmapheresis toimmune cerebrospinal fluid screening revealed a neural- in a patient with encephalopathy, opsoclonus, and my- specific IgG that bound to synapse-rich regions of mouse oclonus whose cerebrospinal fluid was positive for N- hippocampus and cerebellar granular layer; the neural- methyl-D-aspartate receptor–IgG. specific IgG was confirmed to be N-methyl-D-aspartate receptor specific. No neoplasm was detected by physi- Design: Case report. cal examination or by whole-body computed tomogra- phy and positron emission tomography. A 5-day course Setting: St Marys Hospital, Rochester, Minnesota. of high-dose intravenous methylprednisolone sodium suc- cinate yielded limited improvement, and the patient sub- Patient: A 27-year-old woman with a history of epi- sequently required intensive care unit admission follow- sodic migraine developed subacute progressive myoclo- ing a pulseless electrical activity arrest associated with nus, opsoclonus, and encephalopathy. pulmonary embolism. The encephalopathy improved dra- matically after http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

N-methyl-D-aspartate Receptor Autoimmune Encephalitis Presenting With Opsoclonus-Myoclonus

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2011.166
pmid
21825245
Publisher site
See Article on Publisher Site

Abstract

OBSERVATION N-methyl-D-aspartate Receptor Autoimmune Encephalitis Presenting With Opsoclonus-Myoclonus Treatment Response to Plasmapheresis Jonathan H. Smith, MD; Radhika Dhamija, MBBS; Brian D. Moseley, MD; Paola Sandroni, MD, PhD; Claudia F. Lucchinetti, MD; Vanda A. Lennon, MD, PhD; Orhun H. Kantarci, MD Objectives: To report the clinical, laboratory, and ra- evated IgG index, and positive oligoclonal banding. Au- diographic features and the response to plasmapheresis toimmune cerebrospinal fluid screening revealed a neural- in a patient with encephalopathy, opsoclonus, and my- specific IgG that bound to synapse-rich regions of mouse oclonus whose cerebrospinal fluid was positive for N- hippocampus and cerebellar granular layer; the neural- methyl-D-aspartate receptor–IgG. specific IgG was confirmed to be N-methyl-D-aspartate receptor specific. No neoplasm was detected by physi- Design: Case report. cal examination or by whole-body computed tomogra- phy and positron emission tomography. A 5-day course Setting: St Marys Hospital, Rochester, Minnesota. of high-dose intravenous methylprednisolone sodium suc- cinate yielded limited improvement, and the patient sub- Patient: A 27-year-old woman with a history of epi- sequently required intensive care unit admission follow- sodic migraine developed subacute progressive myoclo- ing a pulseless electrical activity arrest associated with nus, opsoclonus, and encephalopathy. pulmonary embolism. The encephalopathy improved dra- matically after

Journal

JAMA NeurologyAmerican Medical Association

Published: Aug 1, 2011

References