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Myosin Degeneration in a Congenital Myopathy

Myosin Degeneration in a Congenital Myopathy Abstract • In a muscle biopsy specimen from a baby girl with hypotonia, there was the ultrastructural finding of selective myosin degeneration in some myofibers. The sarcomeres were either well aligned or completely distorted. Excessive glycogen, fiber and fibril splitting, and occasional aggregates of vesicles were the other abnormalities present. References 1. Munsat TL: Congenital myopathies , in Pearson CM, Mostofi FK (eds): The Striated Muscle . Baltimore, Williams & Wilkins Co, 1973, pp 442-453. 2. Price HM, Gordon GB, Munsat TL, et al: Myopathy with atypical mitochondria in type I skeletal muscle fibers . J Neuropathol Exp Neurol 26:475-495, 1967.Crossref 3. Spiro AJ, Shy GM, Gonates NK: Myotubular myopathy . Arch Neurol 14:1-14, 1966.Crossref 4. Isaacs ER, Bradley WG, Henderson G: Longitudinal fiber splitting in muscular dystrophy . J Neurol Neurosurg Psychiatry 36:813-819, 1973.Crossref 5. Price HM: Ultrastructural pathologic characteristics of the skeletal muscle fiber: An introductory survey , in Pearson CM, Mostofi FK (eds): The Striated Muscle . Baltimore, Williams & Wilkins Co, 1973, pp 144-185. 6. Chacko S, Kelly A, Cartrell J, et al: Effect of 5-bromodeoxyuridine on myosin synthesis and myofibrillogenesis . J Cell Biol 67:59a, 1975. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Myosin Degeneration in a Congenital Myopathy

Yarom, Rena; Shapira, Yehuda
Archives of Neurology , Volume 34 (2) – Feb 1, 1977
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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1977.00500140068014
Publisher site
See Article on Publisher Site

Abstract

Abstract • In a muscle biopsy specimen from a baby girl with hypotonia, there was the ultrastructural finding of selective myosin degeneration in some myofibers. The sarcomeres were either well aligned or completely distorted. Excessive glycogen, fiber and fibril splitting, and occasional aggregates of vesicles were the other abnormalities present. References 1. Munsat TL: Congenital myopathies , in Pearson CM, Mostofi FK (eds): The Striated Muscle . Baltimore, Williams & Wilkins Co, 1973, pp 442-453. 2. Price HM, Gordon GB, Munsat TL, et al: Myopathy with atypical mitochondria in type I skeletal muscle fibers . J Neuropathol Exp Neurol 26:475-495, 1967.Crossref 3. Spiro AJ, Shy GM, Gonates NK: Myotubular myopathy . Arch Neurol 14:1-14, 1966.Crossref 4. Isaacs ER, Bradley WG, Henderson G: Longitudinal fiber splitting in muscular dystrophy . J Neurol Neurosurg Psychiatry 36:813-819, 1973.Crossref 5. Price HM: Ultrastructural pathologic characteristics of the skeletal muscle fiber: An introductory survey , in Pearson CM, Mostofi FK (eds): The Striated Muscle . Baltimore, Williams & Wilkins Co, 1973, pp 144-185. 6. Chacko S, Kelly A, Cartrell J, et al: Effect of 5-bromodeoxyuridine on myosin synthesis and myofibrillogenesis . J Cell Biol 67:59a, 1975.

Journal

Archives of Neurology – American Medical Association

Published: Feb 1, 1977

References

  • The Striated Muscle
    Munsat TL
  • Myopathy with atypical mitochondria in type I skeletal muscle fibers
    Price HM, Gordon GB, Munsat TL, et al
  • Myotubular myopathy
    Spiro AJ, Shy GM, Gonates NK
  • Longitudinal fiber splitting in muscular dystrophy
    Isaacs ER, Bradley WG, Henderson G
  • The Striated Muscle
    Price HM
  • Effect of 5-bromodeoxyuridine on myosin synthesis and myofibrillogenesis
    Chacko S, Kelly A, Cartrell J, et al