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Myocardial Infarct in a Child With Systemic Lupus Erythematosus

Myocardial Infarct in a Child With Systemic Lupus Erythematosus Abstract • An unusual case of systemic lupus erythematosus (SLE) in a young child is reported with sudden death from myocardial infarction. The diagnosis of lupus erythematosus in this patient was made by renal biopsy at the age of 3 years. Atherosclerosis of the coronary arteries and aorta was found at autopsy with occlusion of the anterior descending branch of the left coronary artery. It is suggested that the vascular changes in this case were related to hypertriglyceridemia and prolonged prednisone therapy superimposed on a hypersensitivity vasculitis related to SLE. (Am J Dis Child 132:696-699, 1978) References 1. Jacobs JC: Systemic lupus erythematosus in childhood: Report of 35 cases, with discussion of seven apparently induced by anticonvulsant medication, and of prognosis and treatment . Pediatrics 33:257-264, 1963. 2. Hejtmancik MR, Wright JC, Quint R, et al: The cardiovascular manifestations of systemic lupus erythematosus . Am Heart J 68:119-130, 1964.Crossref 3. Marks AD: The cardiovascular manifestations of systemic lupus erythematosus . Am J Med Sci 264:254-265, 1972.Crossref 4. Tumulty PA: The clinical course of systemic lupus erythematosus . JAMA 156:947-953, 1954.Crossref 5. Griffith GC, Viral IL: Acute and subacute disseminated lupus erythematosus: A correlation of clinical and postmortem findings in 18 cases . Circulation 3:492-500, 1951.Crossref 6. Meller J: Myocardial infarction due to coronary atherosclerosis in three young adults with systemic lupus erythematosus . Am J Cardiol 35:309-314, 1975.Crossref 7. Tsakraklides VG, Glieden LC, Edwards JE: Coronary atherosclerosis and myocardial infarction associated with systemic lupus erythematosus . Am Heart J 87:637-641, 1974.Crossref 8. Rich AR, Gregory JE: Experimental anaphylactic lesions of the coronary arteries of the "sclerotic" type, commonly associated with rheumatic fever and disseminated lupus erythematosus . Bull Johns Hopkins Hosp 81:312-324, 1947. 9. Good TA, Benton JW, Kedy VC: Symptomatology resulting from withdrawal of steroid hormone therapy . Arthritis Rheum 2:299-320, 1959.Crossref 10. Kemper JW, Baggenstoss AH, Slocumb CH: The relationship of therapy with cortisone to the incidence of vascular lesion in rheumatoid arthritis . Ann Intern Med 46:831-851, 1957.Crossref 11. Bulkley BH, Roberts WC: How steroid therapy has changed the heart of systemic lupus erythematosus , (abstracted). Am J Cardiol 31:124, 1973. 12. Bulkley BH, Roberts WC: Systemic lupus erythematosus as a cause of severe mitral regurgitation: New problem in a new disease . Am J Cardiol 35:305-308, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120320056013
Publisher site
See Article on Publisher Site

Abstract

Abstract • An unusual case of systemic lupus erythematosus (SLE) in a young child is reported with sudden death from myocardial infarction. The diagnosis of lupus erythematosus in this patient was made by renal biopsy at the age of 3 years. Atherosclerosis of the coronary arteries and aorta was found at autopsy with occlusion of the anterior descending branch of the left coronary artery. It is suggested that the vascular changes in this case were related to hypertriglyceridemia and prolonged prednisone therapy superimposed on a hypersensitivity vasculitis related to SLE. (Am J Dis Child 132:696-699, 1978) References 1. Jacobs JC: Systemic lupus erythematosus in childhood: Report of 35 cases, with discussion of seven apparently induced by anticonvulsant medication, and of prognosis and treatment . Pediatrics 33:257-264, 1963. 2. Hejtmancik MR, Wright JC, Quint R, et al: The cardiovascular manifestations of systemic lupus erythematosus . Am Heart J 68:119-130, 1964.Crossref 3. Marks AD: The cardiovascular manifestations of systemic lupus erythematosus . Am J Med Sci 264:254-265, 1972.Crossref 4. Tumulty PA: The clinical course of systemic lupus erythematosus . JAMA 156:947-953, 1954.Crossref 5. Griffith GC, Viral IL: Acute and subacute disseminated lupus erythematosus: A correlation of clinical and postmortem findings in 18 cases . Circulation 3:492-500, 1951.Crossref 6. Meller J: Myocardial infarction due to coronary atherosclerosis in three young adults with systemic lupus erythematosus . Am J Cardiol 35:309-314, 1975.Crossref 7. Tsakraklides VG, Glieden LC, Edwards JE: Coronary atherosclerosis and myocardial infarction associated with systemic lupus erythematosus . Am Heart J 87:637-641, 1974.Crossref 8. Rich AR, Gregory JE: Experimental anaphylactic lesions of the coronary arteries of the "sclerotic" type, commonly associated with rheumatic fever and disseminated lupus erythematosus . Bull Johns Hopkins Hosp 81:312-324, 1947. 9. Good TA, Benton JW, Kedy VC: Symptomatology resulting from withdrawal of steroid hormone therapy . Arthritis Rheum 2:299-320, 1959.Crossref 10. Kemper JW, Baggenstoss AH, Slocumb CH: The relationship of therapy with cortisone to the incidence of vascular lesion in rheumatoid arthritis . Ann Intern Med 46:831-851, 1957.Crossref 11. Bulkley BH, Roberts WC: How steroid therapy has changed the heart of systemic lupus erythematosus , (abstracted). Am J Cardiol 31:124, 1973. 12. Bulkley BH, Roberts WC: Systemic lupus erythematosus as a cause of severe mitral regurgitation: New problem in a new disease . Am J Cardiol 35:305-308, 1975.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1978

References