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MUTATION AS A CAUSE OF DISEASE

MUTATION AS A CAUSE OF DISEASE Soon after de Vries advanced the ofmutation in that concept plants, is, permanent, transmissible in the the arose whether mutation change offspring, question naturally occurs also in man. While a few students of have maintained that heredity hereditary diseases and certain anomalies and malformations in man not congenital infrequently arise from unable evidence in to may mutation, although present any indisputable of their until the view has been that mutation proof hypothesis, recently prevailing as a direct cause of disease is rare and oflittle Now extremely practical significance. it has been demonstrated that mutation can be Since ob¬ produced experimentally. servational data are limited few and since human cross to relatively generations be we shall never be able demonstrate not to breeding experiments may performed, with that a human disease arises from mutation. has re¬ certainty hereditary Kemp1 viewed the conditions which are assumed have arisen mutation and to reasonably by for which the mutation rates have been calculated. In relation human disease mutation is of than to gametic greater importance somatic mutation because it is transmitted ofthe from through reproduction species one to another. little is known about somatic mutation generation Actually, although the has been advanced that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

MUTATION AS A CAUSE OF DISEASE

JAMA , Volume 278 (15) – Oct 15, 1997
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MUTATION AS A CAUSE OF DISEASE

Abstract

Soon after de Vries advanced the ofmutation in that concept plants, is, permanent, transmissible in the the arose whether mutation change offspring, question naturally occurs also in man. While a few students of have maintained that heredity hereditary diseases and certain anomalies and malformations in man not congenital infrequently arise from unable evidence in to may mutation, although present any indisputable of their until the view has been that mutation proof hypothesis, recently...
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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1997.03550150020010
Publisher site
See Article on Publisher Site

Abstract

Soon after de Vries advanced the ofmutation in that concept plants, is, permanent, transmissible in the the arose whether mutation change offspring, question naturally occurs also in man. While a few students of have maintained that heredity hereditary diseases and certain anomalies and malformations in man not congenital infrequently arise from unable evidence in to may mutation, although present any indisputable of their until the view has been that mutation proof hypothesis, recently prevailing as a direct cause of disease is rare and oflittle Now extremely practical significance. it has been demonstrated that mutation can be Since ob¬ produced experimentally. servational data are limited few and since human cross to relatively generations be we shall never be able demonstrate not to breeding experiments may performed, with that a human disease arises from mutation. has re¬ certainty hereditary Kemp1 viewed the conditions which are assumed have arisen mutation and to reasonably by for which the mutation rates have been calculated. In relation human disease mutation is of than to gametic greater importance somatic mutation because it is transmitted ofthe from through reproduction species one to another. little is known about somatic mutation generation Actually, although the has been advanced that

Journal

JAMA – American Medical Association

Published: Oct 15, 1997

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