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MUSCULAR DYSTROPHY AND ATROPHY: CLINICAL AND BIOCHEMICAL RESULTS FOLLOWING THE ORAL ADMINISTRATION OF AMINO-ACIDS

MUSCULAR DYSTROPHY AND ATROPHY: CLINICAL AND BIOCHEMICAL RESULTS FOLLOWING THE ORAL... Abstract One of the most perplexing, and yet one of the most interesting problems encountered in medical practice in general, and in clinical neurology in particular, is constituted by that group of patients who are suffering from some form of muscular atrophy or dystrophy. Perhaps the first complete descriptions of the various forms of muscular dystrophy and atrophy were presented about the middle of the nineteenth century during the time of Charcot1 and his colleagues. Since that time numerous investigators have studied the problem in its various phases, and much information has been added toward a thorough comprehension of the characteristic clinical syndromes, with their associated pathologic lesions. Various theories as to the etiology of the condition have been presented and many therapeutic measures have been proposed, none of which have withstood the test of time. The results of many studies have shown that in cases of muscular dystrophy the References 1. Charcot, J. M.: Lectures on Diseases of the Nervous System , Paris, 1868 2. English translation, London, New Sydenham Society, 1877. 3. Levene, P. A., and Kristeller, L.: Factors Regulating the Creatinin Output in Man , Am. J. Physiol. 24:45, 1909. 4. Gibson, R. B., and Martin, F. T.: Creatine Formation in a Case of Progressive Pseudohypertrophic Muscular Dystrophy , J. Biol. Chem. 49:319, 1921. 5. Gibson, R. B.: Martin, F. T., and Buell, M. V. R.: A Metabolic Study of Progressive Pseudohypertrophic Muscular Dystrophy and Other Muscular Atrophies , Arch. Int. Med. 29:82 ( (Jan.) ) 1922.Crossref 6. Beard, H. H., and Barnes, B. O.: The Influence of Feeding Proteins, Amino Acids and Related Substances upon Creatine-Creatinine Metabolism , J. Biol. Chem. 94:49, 1931. 7. Brand, E.; Harris, M. M.; Sandberg, M., and Ringer. A. I.: Studies on the Origin of Creatine , Proc. Internat. Physiol. Congress , 1929, p. 36. 8. Moren, J. J.: Treatment of Muscular Dystrophies , Kentucky M. J. 23:528, 1925. 9. Milhorat, A. T.; Techner, F., and Thomas, K.: Significance of Creatine in Progressive Muscular Dystrophy, and Treatment of This Disease with Glycine , Proc. Soc. Exper. Biol. & Med. 29:609, 1932. 10. Boothby, W. M.: Myasthenia Gravis: A Preliminary Report on the Effect of Treatment with Glycine , Proc. Staff Meet., Mayo Clin. 7:557 ( (Sept. 28) ) 1932. 11. Boothby, W. M.: Myasthenia Gravis: Second Report on the Effect of Treatment with Glycine , Proc. Staff Meet., Mayo Clin. 7:737 ( (Dec. 28) ) 1932. 12. Remen, L.: Zur Pathogenese und Therapie der Myasthenia gravis pseudoparalytica , Deutsche Ztschr. f. Nervenh. 128:66, 1932 13. Cited by Boothby.10 14. Reese, H. H.: Personal communication to one of us (H. H. B.). 15. Taylor, R.: A New Treatment for Myasthenia Gravis , South. Med. & Surg. 94:790, 1932. 16. Milhorat, A. T.: Ueber die Behandlung der progressiven Muskeldystrophie und ähnlicher Muskelerkrankungen mit Glykokoll , Deutsche Arch. f. klin. Med. 174:487, 1933. 17. Quick ( J. A. M. A. 99:57 ( (July 2) ) 1932) 18. Beard, H. H., and Tripoli, C. J.: The Effect of Feeding Amino Acids in Cases of Muscular Dystrophy , J. Biol. Chem. 100:14, 1933. 19. Chanutin, A.; Butt, H. R., and Royster, L. T.: A Study of Progressive Pseudohypertrophic Muscular Dystrophy in Children After the Administration of Glycine and Creatine , J. Biol. Chem. 100:26, 1933. 20. Brand, E., and Harris, M. M.: Further Studies on the Administration of Glycine in Muscular and Neuromuscular Diseases , J. Biol. Chem. 100:20, 1933. 21. Kostakow, S., and Slauck, A.: Glycine Treatment of Progressive Muscular Dystrophy , Deutsche med. Wchnschr. 59:169 ( (Feb. 3) ) 1933. 22. Needham, D.: The Biochemistry of Muscle , London, Methuen & Co., 1932, p. 96. 23. Sullivan, M. X.; Hess, W. C., and Sebrell, W. H.: Studies on the Biochemistry of Sulphur: XII. Preliminary Studies on the Amino-Acid Toxicity and Amino-Acid Balance , Pub. Health Rep. 47:75 ( (Jan. 8) ) 1932. 24. Lillie, R. D.: Histopathologic Changes Produced in Rats by the Addition to the Diet of Various Amino Acids (Glycine, Lysine, Tryptophane, Cystine, Tyrosine and Glutamic Acid, and Glutathione, and of Mixtures of Some of Them) , Pub. Health Rep. 47:83 ( (Jan. 8) ) 1932. 25. Czernecki, W.: Zur Kenntnis des Kreatins und Kreatinins im Organismus , Ztschr. f. phys. Chem. 44:294, 1905. 26. Knoop, F.: Ueber den physiologischen Abbau der Säuren und die Synthese einer Aminosäure im Tierkörper , Ztschr. f. phys. Chem. 67:489, 1910. 27. Neubauer, O.: Abbau der Aminosäuren im Organismus , in Abderhalden: Biochemisches Handlexikon , Berlin, Julius Springer, 1911, vol. 4, p. 360. 28. Hunter, A.: Creatine and Creatinine , London, Longmans, Green & Co., 1928, p. 223 29. Brentano, C.: Untersuchungen über die Entstehung der Kreatinurie: II. Mitteilung: Die Beziehungen zwischen Kreatinurie und Muskelglykogen , Arch. f. exper. Path. u. Pharmakol. 155:21, 1930.Crossref 30. Cited by Moren.7 31. Wechsler, I. S.: A Text-book of Clinical Neurology , Philadelphia, W. B. Saunders Company, 1931, p. 191. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

MUSCULAR DYSTROPHY AND ATROPHY: CLINICAL AND BIOCHEMICAL RESULTS FOLLOWING THE ORAL ADMINISTRATION OF AMINO-ACIDS

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Publisher
American Medical Association
Copyright
Copyright © 1934 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1934.00160090112010
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Abstract

Abstract One of the most perplexing, and yet one of the most interesting problems encountered in medical practice in general, and in clinical neurology in particular, is constituted by that group of patients who are suffering from some form of muscular atrophy or dystrophy. Perhaps the first complete descriptions of the various forms of muscular dystrophy and atrophy were presented about the middle of the nineteenth century during the time of Charcot1 and his colleagues. Since that time numerous investigators have studied the problem in its various phases, and much information has been added toward a thorough comprehension of the characteristic clinical syndromes, with their associated pathologic lesions. Various theories as to the etiology of the condition have been presented and many therapeutic measures have been proposed, none of which have withstood the test of time. The results of many studies have shown that in cases of muscular dystrophy the References 1. Charcot, J. M.: Lectures on Diseases of the Nervous System , Paris, 1868 2. English translation, London, New Sydenham Society, 1877. 3. Levene, P. A., and Kristeller, L.: Factors Regulating the Creatinin Output in Man , Am. J. Physiol. 24:45, 1909. 4. Gibson, R. B., and Martin, F. T.: Creatine Formation in a Case of Progressive Pseudohypertrophic Muscular Dystrophy , J. Biol. Chem. 49:319, 1921. 5. Gibson, R. B.: Martin, F. T., and Buell, M. V. R.: A Metabolic Study of Progressive Pseudohypertrophic Muscular Dystrophy and Other Muscular Atrophies , Arch. Int. Med. 29:82 ( (Jan.) ) 1922.Crossref 6. Beard, H. H., and Barnes, B. O.: The Influence of Feeding Proteins, Amino Acids and Related Substances upon Creatine-Creatinine Metabolism , J. Biol. Chem. 94:49, 1931. 7. Brand, E.; Harris, M. M.; Sandberg, M., and Ringer. A. I.: Studies on the Origin of Creatine , Proc. Internat. Physiol. Congress , 1929, p. 36. 8. Moren, J. J.: Treatment of Muscular Dystrophies , Kentucky M. J. 23:528, 1925. 9. Milhorat, A. T.; Techner, F., and Thomas, K.: Significance of Creatine in Progressive Muscular Dystrophy, and Treatment of This Disease with Glycine , Proc. Soc. Exper. Biol. & Med. 29:609, 1932. 10. Boothby, W. M.: Myasthenia Gravis: A Preliminary Report on the Effect of Treatment with Glycine , Proc. Staff Meet., Mayo Clin. 7:557 ( (Sept. 28) ) 1932. 11. Boothby, W. M.: Myasthenia Gravis: Second Report on the Effect of Treatment with Glycine , Proc. Staff Meet., Mayo Clin. 7:737 ( (Dec. 28) ) 1932. 12. Remen, L.: Zur Pathogenese und Therapie der Myasthenia gravis pseudoparalytica , Deutsche Ztschr. f. Nervenh. 128:66, 1932 13. Cited by Boothby.10 14. Reese, H. H.: Personal communication to one of us (H. H. B.). 15. Taylor, R.: A New Treatment for Myasthenia Gravis , South. Med. & Surg. 94:790, 1932. 16. Milhorat, A. T.: Ueber die Behandlung der progressiven Muskeldystrophie und ähnlicher Muskelerkrankungen mit Glykokoll , Deutsche Arch. f. klin. Med. 174:487, 1933. 17. Quick ( J. A. M. A. 99:57 ( (July 2) ) 1932) 18. Beard, H. H., and Tripoli, C. J.: The Effect of Feeding Amino Acids in Cases of Muscular Dystrophy , J. Biol. Chem. 100:14, 1933. 19. Chanutin, A.; Butt, H. R., and Royster, L. T.: A Study of Progressive Pseudohypertrophic Muscular Dystrophy in Children After the Administration of Glycine and Creatine , J. Biol. Chem. 100:26, 1933. 20. Brand, E., and Harris, M. M.: Further Studies on the Administration of Glycine in Muscular and Neuromuscular Diseases , J. Biol. Chem. 100:20, 1933. 21. Kostakow, S., and Slauck, A.: Glycine Treatment of Progressive Muscular Dystrophy , Deutsche med. Wchnschr. 59:169 ( (Feb. 3) ) 1933. 22. Needham, D.: The Biochemistry of Muscle , London, Methuen & Co., 1932, p. 96. 23. Sullivan, M. X.; Hess, W. C., and Sebrell, W. H.: Studies on the Biochemistry of Sulphur: XII. Preliminary Studies on the Amino-Acid Toxicity and Amino-Acid Balance , Pub. Health Rep. 47:75 ( (Jan. 8) ) 1932. 24. Lillie, R. D.: Histopathologic Changes Produced in Rats by the Addition to the Diet of Various Amino Acids (Glycine, Lysine, Tryptophane, Cystine, Tyrosine and Glutamic Acid, and Glutathione, and of Mixtures of Some of Them) , Pub. Health Rep. 47:83 ( (Jan. 8) ) 1932. 25. Czernecki, W.: Zur Kenntnis des Kreatins und Kreatinins im Organismus , Ztschr. f. phys. Chem. 44:294, 1905. 26. Knoop, F.: Ueber den physiologischen Abbau der Säuren und die Synthese einer Aminosäure im Tierkörper , Ztschr. f. phys. Chem. 67:489, 1910. 27. Neubauer, O.: Abbau der Aminosäuren im Organismus , in Abderhalden: Biochemisches Handlexikon , Berlin, Julius Springer, 1911, vol. 4, p. 360. 28. Hunter, A.: Creatine and Creatinine , London, Longmans, Green & Co., 1928, p. 223 29. Brentano, C.: Untersuchungen über die Entstehung der Kreatinurie: II. Mitteilung: Die Beziehungen zwischen Kreatinurie und Muskelglykogen , Arch. f. exper. Path. u. Pharmakol. 155:21, 1930.Crossref 30. Cited by Moren.7 31. Wechsler, I. S.: A Text-book of Clinical Neurology , Philadelphia, W. B. Saunders Company, 1931, p. 191.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1934

References